Battles With Iron: Manganese In Oxidative Stress Protection


Jan 6, 2015
Battles with Iron: Manganese in Oxidative Stress Protection
The redox-active metal manganese plays a key role in cellular adaptation to oxidative stress. As a cofactor for manganese superoxide dismutase or through formation of non-proteinaceous manganese antioxidants, this metal can combat oxidative damage without deleterious side effects of Fenton chemistry. In either case, the antioxidant properties of manganese are vulnerable to iron. Cellular pools of iron can outcompete manganese for binding to manganese superoxide dismutase, and through Fenton chemistry, iron may counteract the benefits of non-proteinaceous manganese antioxidants. In this minireview, we highlight ways in which cells maximize the efficacy of manganese as an antioxidant in the midst of pro-oxidant iron.

Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1. - PubMed - NCBI

The halophilic archaeon Halobacterium salinarum NRC-1 was used as a model system to investigate cellular damage induced by exposure to high doses of ionizing radiation (IR). Oxidative damages are the main lesions from IR and result from free radicals production via radiolysis of water. This is the first study to quantify DNA base modification in a prokaryote, revealing a direct relationship between yield of DNA lesions and IR dose. Most importantly, our data demonstrate the significance of DNA radiation damage other than strand breaks on cell survival. We also report the first in vivo evidence of reactive oxygen species scavenging by intracellular halides in H. salinarum NRC-1, resulting in increased protection against nucleotide modification and carbonylation of protein residues. Bromide ions, which are highly reactive with hydroxyl radicals, provided the greatest protection to cellular macromolecules. Modified DNA bases were repaired in 2 h post irradiation, indicating effective DNA repair systems. In addition, measurements of H. salinarum NRC-1 cell interior revealed a high Mn/Fe ratio similar to that of Deinococcus radiodurans and other radiation-resistant microorganisms, which has been shown to provide a measure of protection for proteins against oxidative damage. The work presented here supports previous studies showing that radiation resistance is the product of mechanisms for cellular protection and detoxification, as well as for the repair of oxidative damage to cellular macromolecules. The finding that not only Mn/Fe but also the presence of halides can decrease the oxidative damage to DNA and proteins emphasizes the significance of the intracellular milieu in determining microbial radiation resistance.


Jun 16, 2015
Possible mechanism behind health benefits of tea. It's high in manganese and binds iron so it can help regulate the balance
Similar threads
Thread starter Title Forum Replies Date
M GMO Banning Battles Miscellaneous Health Discussions 11
E High blood iron but normal ferritin levels? Ask For Help or Advice 17
Recoen Iron Fortification Minerals 0
belcanto Estrogen, iron, degenerative aging, and progesterone - and Lactoferrin! Articles & Newsletters Discussion 20
E Lower range DHEA, 500s Total Testosterone, Lower range Iron/Ferittin, High Free T3, TSH 3.0 20 year old male Blood Work, Labs 6
F Do the Amish cook with vegetable oil and iron-enriched flour? Miscellaneous 9
miraddo Men store up to 4.6 times more Iron than age-matched women Scientific Studies 2
B "Long COVID" mechanisms explained - a bioenergetic disruption involving iron Viruses, Parasites, Fungus, Vaccines 1
haidut Iron supplementation may not cure anemia, unless nutrition is also improved Scientific Studies 1
youngsinatra Vitamin A + Iron Supplementation As Effective As TRT In Puberty-Delayed Individuals Male Issues 1
ddjd Iron status is crucial factor in determining vulnerability to COVID Ask For Help or Advice 5
Jon2547 Iron and copper deposits in the brain Scientific Studies 2
M How Would You Counter Iron Overload? Minerals 10
M Blocking iron from eating liver Ask For Help or Advice 10
Doludolu Very LOW Iron , Sufficient Ferritin, Excesivelly high vitamin B12 - Anemia or what is going on? Blood Work, Labs 9
A Iron metabolism in aging Scientific Studies 1
J Am I good to eat red meat with H63D gene as long as i donate blood, eat iron rich foods with calcium Minerals 4
TacoVampire Blood work/ endo/ fatigue / low iron Blood Work, Labs 5
D Anemia in senior male - any iron metabolism Wizards / practitioners in here? Ask For Help or Advice 3
username I Need Help Understanding My TSH And Complete Iron Panel Blood Work, Labs 7
A Onions Increase The Amount Of Iron Absorbed From Grains Ask For Help or Advice 9
A Would Drinking Coffee Along With Turmeric Inhibit Iron Absorption? Ask For Help or Advice 5
A My Iron Levels Are Ok? Ask For Help or Advice 0
A Exposure Of Iron Knife With Food Ask For Help or Advice 14
haidut Alcohol Brain Damage Due To Iron Accumulation; Vitamin B1 To The Rescue Scientific Studies 3
ecstatichamster Ray Peat Interview #35: CO2, Ketosis, And Mitochondria | PUFA, Sugar, Iron, And AGEs | Progesterone And Cell Stabil Danny Roddy 21
Ms.Orchid Need Some Help Figuring Out Iron Labs Blood Work, Labs 1
S Symptoms Of Anemia Despite Iron Supplementation Female Issues 4
B Magnesium Fixed My Iron Overload Testimonials 12
Frankdee20 Good Dose Of Creatine ? Not For Pumping Iron Ask For Help or Advice 8
J Red Meat And Bad Sleep - Iron Overload? Insomnia, Sleep Issues 11
S High Iron Saturation, Normal Ferritin Blood Work, Labs 1
ampersand Ataxia, Iron, Methylene Blue, Niacinamide Supplements, Pharmaceutical Drugs 2
S.Seneff Russia Compounds That Chelate Iron And Inhibits Potential Mitochlndrial Calcium Overload Scientific Studies 2
md_a IRON And Covid-19 Scientific Studies 0
md_a Vitamin C Helps Covid-19 Infected Patients By Regulating Iron? Scientific Studies 5
M Anti-Peat Dietary (organic) Iron Does Not Increase Tissue Iron Debate - Anti-Peat 40
md_a High Levels Of Iron In The Lung Linked To Increased Asthma Severity Scientific Studies 0
md_a Bacterial Endotoxin (lipopolysaccharide) Stimulates The Rate Of Iron Oxidation Scientific Studies 1
Xemnoraq Iron Bits Found In Refined Sugar? Sugar, Honey 12
Max. Drink White Grape.juice Can Increase Iron? Diet, Recipes 3
Such_Umami Fasting To Lower Iron Content? Ask For Help or Advice 2
Such_Umami Question Regarding Iron Ask For Help or Advice 1
T Please Help With Confusing Iron Test Blood Work, Labs 5
zarrin77 Glycine Completely Protects Liver Cells From Apoptosis Due To Iron Scientific Studies 1
postman What Foods Are The Lowest In Iron? Diet 0
Evgenij UVA Radiation Leads To An Immediate Increase In The Free Available Iron Scientific Studies 1
M Iron Lowering Effect Of Aspirin Ask For Help or Advice 5
Lokzo Does Vitamin E Chelate/Lower Iron Or Just Protect Against Excess? E 7

Similar threads