Homo Consumericus
Member
Wow I forgot that, I'm taking 5mg Selegine per week (for its effect on MAO-B) and I decided to take some Cypro for better sleep yesterday, and today I was not feeling well at all, maybe there were too much anti-cholinergic effects going on.
Having noticed you're in Germany, where do you purchase it (selegiline/deprenyl)?
Also, Life Extension seems to believe selegiline would be pro-acetylcholinergic. From their article, "Excess MAO-B not only deprives us of our youthful emotions by depleting dopamine, but also impairs cognitive functions by decreasing acetylcholine while simultaneously accelerating brain aging.51-55"
Here are their references:
51. Carageorgiou H, Zarros A, Tsakiris S. Selegiline long-term effects on brain acetylcholinesterase, (Na+,K+)-ATPase activities, antioxidant status and learning performance of aged rats. Pharmacol Res. 2003;48(3):245-51.
52. Delumeau JC, Bentue-Ferrer D, Gandon JM, et al. Monoamine oxidase inhibitors, cognitive functions and neurodegenerative diseases. J Neural Transm Suppl. 1994;41:259-66.
53. Lecht S, Haroutiunian S, Hoffman A, et al. Rasagiline - a novel MAO B inhibitor in Parkinson’s disease therapy. Ther Clin Risk Manag. 2007;3(3):467-74.
54. Minami M, Hamaue N, Endo T, et al. Effects of isatin, an endogenous MAO inhibitor, on dopamine (DA) and acetylcholine (ACh) concentrations in rats. Nihon Yakurigaku Zasshi. 1999;114 Suppl 1:186p-91p.
55. Petzer JP, Castagnoli N, Jr., Schwarzschild MA, et al. Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson’s disease. Neurotherapeutics. 2009;6(1):141-51.
We would need to read to see if they are interpreting them correctly and then contrast with Dr. Peat's references. You wanna start? I'm off to the gym!