Autoimmunity And "protein Folding"

[Pointless]

Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases. - PubMed - NCBI

Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity?... - PubMed - NCBI

ER Stress Proteins in Autoimmune and Inflammatory Diseases

The role of adenosinergic pathway in human autoimmune diseases

Exploring some TUDCA rabbit holes and considering the role of atp and er stress in the pathogenesis of autoimmune disease.

 

[Terma]

This is a very good topic, so I will just bump this for moral reasons. I can't contribute that much, but years ago it was believed TUDCA mainly benefited the liver, when in fact (as discovered only about 3 years ago) some of its best effects were in preventing ER/UPR stress in the hypothalamus (only partially - certainly not all - attributable to leptin):
http://diabetes.diabetesjournals.org/content/diabetes/early/2016/09/14/db15-1547.full.pdf
Sci-Hub | Hypothalamic ER stress: A bridge between leptin resistance and obesity | 10.1016/j.febslet.2015.04.025

The same idea can be applied (probably) to the immune system in several ways.

ER/UPR stress is certainly an important phenomenon and it's gotten sidelined by "antioxidants" (Vit C/E/flavonoids/etc) which do not necessarily address it.

It's mostly likely not a cure in terms of autoimmune disorders (I extremely doubt that) but could help lower symptoms.

It's just to point out ER/UPR stress is a systemic phenomenon rather than purely a liver one.

 

[ecstatichamster]

Is it really better than taurine?