Autism Study Suggests Connection Between Repetitive Behaviors And Gut Problems

[Mauritio]

We are getting closer to mainstream medicine accepting that autism is caused / associated hy increased serotonin
If you replace "gut problems" with serotonin in this article, it's actually a great read .
The only question that they have to ask now is :" If autism is associated with gut problems , what are gut problems associated with?" (--> serotonin) ,but we will get there

Autism study suggests connection between repetitive behaviors, gut problems: Severity of GI symptoms, other autism symptoms also associated

 

[tankasnowgod]

We are getting closer to mainstream medicine accepting that autism is caused / associated hy increased serotonin
If you replace "gut problems" with serotonin in this article, it's actually a great read .
The only question that they have to ask now is :" If autism is associated with gut problems , what are gut problems associated with?" (--> serotonin) ,but we will get there

Autism study suggests connection between repetitive behaviors, gut problems: Severity of GI symptoms, other autism symptoms also associated

Weird. This is along the same lines as Parkinson's Disease. As Haidut posted, it may also begin in the gut-

Parkinson Disease (PD) may begin in the gut – To Extract Knowledge from Matter

Is it possible, once again, we are really looking as the same disease, just seeing the effects in differently aged organisms?

Child with Autism doing hand flapping-



Elderly man with Parkinson's Hand Tremor-



Maybe the child's motions are more exaggerated because he has more overall energy available? We have a pretty famous example of someone with Parkinson's in between those two...... Michael J. Fox-





To almost quote a very crass (but oddly acurate) phrase....

Same Serotonin. Different Age Group.

 

[GelatinGoblin]

Why is it that I see that people say they
have relief when it comes to ADHD and the more relevent OCD in the comment section of videos about SSRIs or commercial SSRIs on YouTube?

 

[Mauritio]

Weird. This is along the same lines as Parkinson's Disease. As Haidut posted, it may also begin in the gut-

Parkinson Disease (PD) may begin in the gut – To Extract Knowledge from Matter

Is it possible, once again, we are really looking as the same disease, just seeing the effects in differently aged organisms?

Child with Autism doing hand flapping-



Elderly man with Parkinson's Hand Tremor-



Maybe the child's motions are more visible because he has more overall energy available? We have a pretty famous example of someone with Parkinson's in between those two...... Michael J. Fox-





To almost quote a very crass (but oddly acurate) phrase....

Same Serotonin. Different Age Group.

Interesting connection!
The tremor is also present in the animal world. After experiencing traumatic experiences (serotonin involved !) animals start shaking uncontrollably for a short amount of time .
Maybe the tremor is physiological effort to get rid of a trauma ,literally shaking it off . And Parkinson's patients or autistic people are somehow stuck in that mode ?!

 

[Mauritio]

Weird. This is along the same lines as Parkinson's Disease. As Haidut posted, it may also begin in the gut-

Parkinson Disease (PD) may begin in the gut – To Extract Knowledge from Matter

Is it possible, once again, we are really looking as the same disease, just seeing the effects in differently aged organisms?

Child with Autism doing hand flapping-



Elderly man with Parkinson's Hand Tremor-



Maybe the child's motions are more exaggerated because he has more overall energy available? We have a pretty famous example of someone with Parkinson's in between those two...... Michael J. Fox-





To almost quote a very crass (but oddly acurate) phrase....

Same Serotonin. Different Age Group.

Overlap between Parkinson's and autism:
Neurological considerations: autism and Parkinson's disease - PubMed

Higher risk for patients with autism to develop Parkinson's (although small sample size) :
High rates of parkinsonism in adults with autism - PubMed

 

[GelatinGoblin]

Interesting connection!
The tremor is also present in the animal world. After experiencing traumatic experiences (serotonin involved !) animals start shaking uncontrollably for a short amount of time .
Maybe the tremor is physiological effort to get rid of a trauma ,literally shaking it off . And Parkinson's patients or autistic people are somehow stuck in that mode ?!

Unlikely! I think it's an expression of stress in animals, perhaps they are ready to move instantly and have fast reaction time but when they do not move and are still and their body is still in this readiness and just shake because of all the energy. Don't humans have this too? Isn't this just shaking? Maybe in smaller animals it's more pronounced, but people shake as well under stress, after stress or recovering from stress. Maybe it is something Serotogenic though. Have there been studies on the stress response with inhibited Serotonin release? That'd be interesting.

Another thing. Isn't autism just lax Thyroid function, Serotonin crossing blood-gut barrier and Serotogenic and unhealthy development while in the womb?

 

[tankasnowgod]

Why is it that I see that people say they
have relief when it comes to ADHD and the more relevent OCD in the comment section of videos about SSRIs or commercial SSRIs on YouTube?

Because, at the very least, SSRIs can antagonize certain serotonin receptors, or can "paradoxically" lower serotonin in acute doses, at least according to this study Mauritio posted in a another thread-

Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality

"Studies of healthy volunteers have primarily employed two techniques to investigate serotonin function: acute tryptophan depletion (ATD), a dietary technique that temporarily lowers brain serotonin levels by depleting its biosynthetic precursor, tryptophan (Bel & Artigas 1996; Biggio et al. 1974; Crockett et al. 2012a; Hood et al. 2005; Nishizawa et al. 1997), and treatment with single doses of selective serotonin reuptake inhibitors (SSRIs). SSRIs are generally assumed to increase extracellular serotonin, however it should be noted that single rather than chronic doses can paradoxically decrease serotonin in projection areas (Cools et al. 2008; Nord et al. 2013). ATD studies have revealed disinhibition of retaliatory behaviour in the face of perceived injustice (Crockett et al. 2008), modelled using the Ultimatum Game (UG) which is defined in Figure 1, whilst single dose SSRI has had pro-social effects (Crockett et al. 2010a)."

Haidut has also pointed out that serveral SSRIs can increase allopregnanolone. So, they aren't simply just raising serotonin. The may indeed be doing some positive things, despite the very negative effect of chronically raising serotonin.

 

[Mauritio]

Unlikely! I think it's an expression of stress in animals, perhaps they are ready to move instantly and have fast reaction time but when they do not move and are still and their body is still in this readiness and just shake because of all the energy. Don't humans have this too? Isn't this just shaking? Maybe in smaller animals it's more pronounced, but people shake as well under stress, after stress or recovering from stress. Maybe it is something Serotogenic though. Have there been studies on the stress response with inhibited Serotonin release? That'd be interesting.

Another thing. Isn't autism just lax Thyroid function, Serotonin crossing blood-gut barrier and Serotogenic and unhealthy development while in the womb?

I agree , I'd like to see those studies too. But there is something up with shaking amd trauma , theres is even a technique ,I forgot the name , many veterans do it , where you do several exercises to get your body shake uncontrollably and then your body releases trauma apparently .

 

[Mauritio]

Case Report of a Former Soldier Using TRE (Tension/Trauma Releasing Exercises) For PostTraumatic Stress Disorder Self-Care

 

[GelatinGoblin]

Case Report of a Former Soldier Using TRE (Tension/Trauma Releasing Exercises) For PostTraumatic Stress Disorder Self-Care

Thanks

 

[Mauritio]

Serotonin antagonist for autistic behavior.

Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder - PubMed

Autism spectrum disorder (ASD) is characterized by the expression of restricted repetitive behaviors (RRBs) and impairments in social recognition and communication. Previous studies have found that specific serotonin (5-HT) receptor modulation can attenuate repetitive behaviors expressed in...

pubmed.ncbi.nlm.nih.gov

 

[Mauritio]

"...contributing to the hyperserotonemia that is often evident in ASD, with consequences for mitochondria functioning and the content of released exosomes."

Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs - PubMed

Such a perspective readily incorporates previously disparate bodies of data in ASD, including the role of the mu-opioid receptor, dopamine signaling and dopamine receptors, as well as the changes occurring to oxytocin and taurine levels. This has a number of treatment implications, the most...

pubmed.ncbi.nlm.nih.gov

 

[Grapelander]

autism is caused / associated hy increased serotonin

I would say that is an 'effect' (associated) of having autism and not a cause.
Autism was not even on the radar when I was young.

 

[Grapelander]

"...contributing to the hyperserotonemia that is often evident in ASD, with consequences for mitochondria functioning and the content of released exosomes."

Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs - PubMed

Such a perspective readily incorporates previously disparate bodies of data in ASD, including the role of the mu-opioid receptor, dopamine signaling and dopamine receptors, as well as the changes occurring to oxytocin and taurine levels. This has a number of treatment implications, the most...

pubmed.ncbi.nlm.nih.gov

Thanks - This study is helpful.

"This has a number of treatment implications, the most readily applicable being the utilization of sodium butyrate and melatonin."