Asthma And Serotonin: How To Address The Cause

alywest

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Thanks for sharing. Too bad you can only order the tianeptine in South Africa. :(
 

postman

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Keeping PUFA intake below 4g per day, and keeping VA intake low as well, practically makes my asthma go away completely.

Tianeptine is a very psychoactive drug, I wouldn't nilly willy recommend it as a first line asthma treatment. It affects serotonin, dopamine, glutamate, and opiod receptors. It is effective for asthma though.
 
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Hans

Hans

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Thanks for sharing. Too bad you can only order the tianeptine in South Africa. :(
There are definitely suppliers in America as well.
Keeping PUFA intake below 4g per day, and keeping VA intake low as well, practically makes my asthma go away completely.

Tianeptine is a very psychoactive drug, I wouldn't nilly willy recommend it as a first line asthma treatment. It affects serotonin, dopamine, glutamate, and opiod receptors. It is effective for asthma though.
It's not "very" psychoactive. It's definitely on the safer side compared to other drugs or nootropics and is very effective and safe in small amounts, like 12.5mg as I mentioned in the article.
 
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asthma is very easy to fix with the Buteyko method, but it takes some work and commitment.

There are other health problems that can be fixed with increasing CO2 levels in the body, which is what Buteyko does. But asthma is the easiest and first to resolve even for a minimal effort.
 
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Hans

Hans

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asthma is very easy to fix with the Buteyko method, but it takes some work and commitment.

There are other health problems that can be fixed with increasing CO2 levels in the body, which is what Buteyko does. But asthma is the easiest and first to resolve even for a minimal effort.
Yeah good one. CO2 is a serotonin antagonist and low CO2 increases free serotonin.
 

Lejeboca

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In addition to stress and gut endotoxin, here is another source of serotonin for promoting trachea contractions in asthma:
its release from mast cells.

Mast cell‐derived serotonin enhances methacholine‐induced airway hyperresponsiveness in house dust mite‐induced experimental asthma


Results: Repeated intranasal HDM sensitization induced allergic airway inflammation associated with accumulation and activation of lung mast cells. Lack of mast cells, absence of activating Fc‐receptors, or antagonizing serotonin (5‐HT)2A receptors abolished HDM‐induced trachea contractions. HDM‐sensitized mice lacking mast cells had diminished lung‐associated 5‐HT levels, reduced [airway hyperresponsiveness] AHR and methacholine‐induced airway contraction, while blocking 5‐HT2A receptors in wild types eliminated AHR, implying that mast cells contribute to AHR by releasing 5‐HT. Primary mouse and human lung mast cells express muscarinic M3 receptors. Mouse lung mast cells store 5‐HT intracellularly, and methacholine induces release of 5‐HT from lung‐derived mouse mast cells and Ca2+ flux in human LAD‐2 mast cells.

 
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Hans

Hans

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In addition to stress and gut endotoxin, here is another source of serotonin for promoting trachea contractions in asthma:
its release from mast cells.

Mast cell‐derived serotonin enhances methacholine‐induced airway hyperresponsiveness in house dust mite‐induced experimental asthma


Results: Repeated intranasal HDM sensitization induced allergic airway inflammation associated with accumulation and activation of lung mast cells. Lack of mast cells, absence of activating Fc‐receptors, or antagonizing serotonin (5‐HT)2A receptors abolished HDM‐induced trachea contractions. HDM‐sensitized mice lacking mast cells had diminished lung‐associated 5‐HT levels, reduced [airway hyperresponsiveness] AHR and methacholine‐induced airway contraction, while blocking 5‐HT2A receptors in wild types eliminated AHR, implying that mast cells contribute to AHR by releasing 5‐HT. Primary mouse and human lung mast cells express muscarinic M3 receptors. Mouse lung mast cells store 5‐HT intracellularly, and methacholine induces release of 5‐HT from lung‐derived mouse mast cells and Ca2+ flux in human LAD‐2 mast cells.
That's why tianpetine works so well, because it enhances uptake of serotonin by the mast cells.
 

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