Associations Between Aspirin And Other NSAIDs And Aortic Valve Or Coronary Artery Calcification: The

paymanz

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Associations between Aspirin and other non-steroidal anti-inflammatory drugs and aortic valve or coronary artery calcification: The Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study



BACKGROUND:

The association between non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence of valvular and arterial calcification is not well established despite known associations between these drugs and cardiovascular events.
OBJECTIVE:

To compare the association between the baseline use of aspirin with other NSAID class medications with the incidence and prevalence of aortic valve calcification (AVC) and coronary artery calcification (CAC).
METHODS:

The relationship of NSAID use to AVC and CAC detected by computed tomography was assessed in 6814 participants within the Multi-Ethnic Study of Atherosclerosis (MESA) using regression modeling. Results were adjusted for age, sex, ethnicity, study site, anti-hypertensive medication use, education, income, health insurance status, diabetes, smoking, exercise, body mass index, blood pressure, serum lipids, inflammatory markers, fasting glucose, statin medication use, and a simple diet score. Medication use was assessed by medication inventory at baseline which includes the use of non-prescription NSAIDs. MESA collects information on both incident and prevalent calcification. The 4814 participants of the Heinz Nixdorf Recall (HNR) Study, a German prospective cohort study with similar measures of calcification, were included in this analysis to enable replication.
RESULTS:

Mean age of the MESA participants was 62 years (51% female). After adjustment for possible confounding factors, a possible association between aspirin use and incident AVC (Relative Risk(RR): 1.60; 95%Confidence Interval (CI): 1.19-2.15) did not replicate in the HNR cohort (RR: 1.06; 95%CI: 0.87-1.28). There was no significant association between aspirin use and incident CAC in the MESA cohort (RR 1.08; 95%CI: 0.91-1.29) or in the HNR cohort (RR 1.24; 95%CI: 0.87-1.77). Non-aspirin NSAID use was not associated with either AVC or CAC in either cohort. There were no associations between regular cardiac dose aspirin and incident calcification in either cohort.
CONCLUSION:

Baseline NSAID use, as assessed by medication inventory, appears to have no protective effect regarding the onset of calcification in either coronary arteries or aortic valves.
 
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paymanz

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i looked at this again today and it looks like aspirin really increases calcification of arteries risk.probably because their vitamin k intake is low?



"For incident AVC, there was no risk with Cardiac Aspirin (aRR 1.2; 95%CI: 0.7 to 2.1) or Occasional High Dose Aspirin (aRR 1.3; 95%CI: 0.6 to 2.8) but a possible association with Regular High Dose Aspirin (aRR: 1.6; 95%CI: 1.1 to 2.3), although this was not defined as an a priori risk category. For incident CAC, there was no risk with Cardiac Aspirin (aRR 1.1; 95%CI: 0.9 to 1.5), Occasional High Dose Aspirin (aRR 1.2; 95%CI: 0.8 to 1.7) or Regular High Dose Aspirin (aRR: 1.1; 95%CI: 0.9 to 1.4)"
 
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