Patent WO2013179098A1 - Association of potassium caproyl tyrosine, l-phenylalanine and taurine and use thereof to prevent and slow down white hair
A topical application with a few familiar amino acids:
In this one, the gelatin prevented those amino acids from reaching the level required for normal colour:
Red Hair in Black Cats Is Reversed by Addition of Tyrosine to the Diet
A topical application with a few familiar amino acids:
In vitro studies have shown how the association according to the present invention formed of potassium caproyl tyrosine in synergy with L-phenylalanine and taurine reaches the deep part of the follicular ostium, modulating tyrosinase expression as early as 72 hours after application in a dose-dependent manner compared to the untreated control.
In this one, the gelatin prevented those amino acids from reaching the level required for normal colour:
Phenylalanine is an essential amino acid for kittens, but tyrosine is a dispensable amino acid (14). The normal pathway of phenylalanine metabolism is hydroxylation to tyrosine, catalyzed by phenylalanine hydroxylase. Because tyrosine is the precursor of melanin, the sum of both AAs may be used to calculate the TAAA in the diet for melanin synthesis. These studies have shown that a dietary concentration of 16.5 g of TAAA/kg diet supplied as isolated AA is inadequate to maintain coat color, whereas 24 g/kg diet is adequate. In experiment 5, when the gelatin diet was supplemented with tyrosine and given to the cats, even the highest level of supplementation was inadequate.
Red Hair in Black Cats Is Reversed by Addition of Tyrosine to the Diet
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