Aspirin's Effects On Testes?

[Krigeren]

A while back I read several articles covering a study suggesting that chronic ibuprofen use could injure the testes, including causing 'compensated hypogonadism' (lower testosterone to LH ratio).

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

Also mentioned in that paper:
"Previous ex vivo studies on adult testis have indeed pointed to an antiandrogenicity, only on Leydig cells, of phthalates (41), aspirin, indomethacin (42), and bisphenol A (BPA) and its analogs (43)."

The study referring to aspirin can be found here:
https://www.physiology.org/doi/full/10.1152/ajpendo.1999.277.6.E1032

After reading the initial articles on ibuprofen (which I've used occasionally for joint pain), I looked up the paper specifically to see if aspirin (also have used for occasional joint pain) was mentioned as well, being that they are both NSAID's.

This might have been covered before, but if so I couldn't find it on here.. Wondering what some of the more scientifically astute members here may think of the potential for long-term / chronic aspirin use causing similar issues?

Thanks.

 

[Gone Peating]

What would be the way to reverse this?

 

[MatheusPN]

From the study:
"However, with regard to human testis, these possibilities seem to be unlikely because the present study indicates that aspirin treatment does not affect steroidogenesis in conditions of nonexposure to exogenous hCG. As a consequence, the aspirin inhibition of androgen response to chorionic gonadotropin may more likely be explained by the drug's interference with the LH-hCG action on the plasma membrane of Leydig cells. "

"Therefore, it is possible that aspirin can block the coupling of occupied LH receptors to phospholipase C, considering that the dose of chorionic gonadotropin used in the present study was high, compared with the endogenous LH levels. Moreover, this hypothesis could explain the discrepancy between the results obtained when the subjects were not exposed to exogenous hCG and under chorionic gonadotropin stimulation."

"In conclusion, the present study shows, for the first time to our knowledge, that in humans androgen response to chorionic gonadotropin is inhibited by aspirin treatment and that the action of the drug is probably mediated via an effective arachidonate cyclooxygenase block."

 

[Krigeren]

From the study:
"However, with regard to human testis, these possibilities seem to be unlikely because the present study indicates that aspirin treatment does not affect steroidogenesis in conditions of nonexposure to exogenous hCG. As a consequence, the aspirin inhibition of androgen response to chorionic gonadotropin may more likely be explained by the drug's interference with the LH-hCG action on the plasma membrane of Leydig cells. "

"Therefore, it is possible that aspirin can block the coupling of occupied LH receptors to phospholipase C, considering that the dose of chorionic gonadotropin used in the present study was high, compared with the endogenous LH levels. Moreover, this hypothesis could explain the discrepancy between the results obtained when the subjects were not exposed to exogenous hCG and under chorionic gonadotropin stimulation."

"In conclusion, the present study shows, for the first time to our knowledge, that in humans androgen response to chorionic gonadotropin is inhibited by aspirin treatment and that the action of the drug is probably mediated via an effective arachidonate cyclooxygenase block."

Thank you.

 

[MatheusPN]

Thank you.

You're welcome ;-)

 

[Frankdee20]

So Asprin always gets bunched in with these NSAID drugs for the purposes of nomenclature, are they related or not ? We see the study where it is deemed to lower Testosterone, and be bad for ED (NSAID'S). What is really going on here ....

 

[ecstatichamster]

I would imagine taking vitamin K2 MK4 can neutralize any damage.

 

[lampofred]

I don't think it would damage the testes, probably the opposite, but it might be using up nutrients such as glycine and Vit K quickly due to its acceleration of metabolism, which would lead to lower testosterone in the long-run if your nutrition is inadequate.

 

[MatheusPN]

Direct from a study that Haidut discuss

"...Depressed gonadal function resulting from the EFA deficiency was further evidenced by a reduced gonadotropin receptor content, a blunted E2 response to hCG in vitro, and an increase in mean serum FSH levels. These results suggest that the delay in puberty resulting from EFA deficiency is due to a reduced availability of arachidonic acid for synthesis of bioactive metabolites. This results in delayed development of both the hypothalamic and ovarian components of the reproductive axis."

Aspirin reduces estrogen and inflammation/ prostaglandin production which then results in a blunted response to hCG, seems likely; maybe hCG in an adult male would be higher than normal to compensate a hypogonadism

@Amazoniac I'm curious about your opinion, principally on hCG, and thanks for the new Grant thread!
Very tempting to ask Haidut about that study on puberty...