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- Sep 26, 2017
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More evidence that Aspirin protects against Endotoxin:
Aspirin reverts lipopolysaccharide-induced learning and memory impairment: first evidence from an invertebrate model system - Naunyn-Schmiedeberg's Archives of Pharmacology
By employing a reductionistic (but not simplistic) approach using an established invertebrate model system, the pond snail Lymnaea stagnalis, we investigated whether (1) lipopolysaccharide (LPS)-induced inflammation would cause a sickness state and impair cognitive function, and—if so—(2) would...
link.springer.com
LPS induced a sickness state that increased aerial respiration and altered the ability of snails to form or recall long-term memory. ASA reverted the LPS-induced sickness state and thus allowed long-term memory both to be formed and recalled. We confirmed our hypotheses and provided the first evidence in an invertebrate model system that an injection of LPS results in a sickness state that obstructs learning and memory, and this impairment can be prevented by a non-steroidal anti-inflammatory.