Effect of graded doses of acetylsalicylic acid on sperm chromatin integrity and maturity of germinal epithelium in adult male mouse Mahmoudi-Lafout F, Mohammadghasemi F - Asian Pac J Reprod
Asian Pacific Journal of Reproduction, Hainan Medical University
"ASA reduced sperm count and movement maybe due to a decrease in androgen level. In this study, serum testosterone was decreased. Epididymis is the main site of sperm maturation and is an organ that is completely androgen dependent. Obviously, in episodes of decreased testosterone, the function of epithelium of epididymis is altered, which may also be due to the toxic effects of aspirin on epithelial cells
In conclusion, results of the present study showed that administration of ASA over the 14 days in dose of 5.00 mg increases sperm DNA fragmentation index and therefore reduces DNA integrity and in doses of 0.50, 1.00, 5.00 mg reduces serum testosterone level without having effect on LH. Generally ASA has deleterious effects on the male reproductive indices even in low doses."