Aspirin May Prevent Gallbladder Stones

Discussion in 'Scientific Studies' started by haidut, May 21, 2015.

  1. haidut

    haidut Member

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    Some people on the forum have complained of potential gallbladder stones and/or inflammation. This study says aspirin may be of some help.

    http://www.ncbi.nlm.nih.gov/pubmed/2114725

    "...This article reviews our present knowledge concerning the so-called sludge, an echographic entity, which is formed by mucus and cholesterol microcrystals. Several physiological and pathological states are associated with gallbladder sludge. Experimental data suggest that sludge could precede gallstones and that aspirin could be used as a preventive agent against the appearance of gallbladder sludge and stones."
     
  2. chris

    chris Member

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    Thanks for posting this haidut. Any ideas of the dosage of aspirin required to do this?
     
  3. OP
    haidut

    haidut Member

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    Don't know, article is in French and not available for download. I think I saw a study on rats showing protection of liver and gallbladder by aspirin in human doses of <500mg daily.
    Also, this human study shows positive effects from 350mg a day for 2 weeks.
    http://www.ncbi.nlm.nih.gov/pubmed/7648980
     
  4. Tommix

    Tommix Member

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    I think ALL acids in bladder helps for this, acetylsalicylic acid is no exception :)
     
  5. ecstatichamster

    ecstatichamster Member

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    very curious about whether taurine works this way too...
     
  6. Wagner83

    Wagner83 Member

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    Effect of aspirin on gallbladder motility in patients with gallstone disease. A randomized, double-blind, placebo-controlled trial of two dosage sc... - PubMed - NCBI
    Can aspirin prevent gallstone recurrence after successful extracorporeal shockwave lithotripsy? - PubMed - NCBI

     
  7. michael94

    michael94 Member

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    Yea there is other evidence to support this idea.... https://www.sciencedaily.com/releases/2016/04/160419130320.htm

    Bile duct cancer is simply an advanced stage of cholestasis ( the cancer is protective against the accumulation of toxins ). The symptoms of bile duct cancer are exactly the same as cholestasis/clogged bile ducts.
    When bile cannot flow properly you get jaundice, cholestatic pruritus ( itching ), pale st0ols... Not uncommon symptoms in those with chronic digestive issues.
    Here is the reasoning provided for aspirin's beneficial effects.
    Interesting...well we know the mechanisms through which hepatic and gallbladder stones are formed. Cholesterol concentration begins to exceed the rate at which it can be kept soluble by bile salts, and lecithin/PUFA. So anything which disturbs bile salt production/recycling and/or lecithin/pufa concentrations will contribute to formation of these stones. Usually it is toxins, whether from exogenous or endogenous source. And yes that's right pufa is apparently important for lecithin to keep cholesterol's melting point below body temperature...What that means for ideal dietary intake remains a mystery to me. Clearly it is more complex than eat less or eat more. On a related note, here is an interesting case study: Enjoy Eating Eggs?

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    The specific effects of aspirin on bile solubility should be studied and explained in more depth than just lowering inflammation. I suspect something more fundamental may be going on. Inflammation is a secondary effect is it not?

    malic acid is known to help soften stones so you bring up a very good point...
     
  8. Wagner83

    Wagner83 Member

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    So magnesium malate should be quite beneficial as a daily preventive measure.
     
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