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Aspirin Lowers Serum Ferritin Levels

Discussion in 'Scientific Studies' started by haidut, Oct 1, 2015.

  1. haidut

    haidut Member

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    It has long been known that people taking aspirin have lower serum iron levels, but I think this is one of the few studies that shows an effect of aspirin on ferritin as well. So, taking aspirin could be an alternative to giving blood. Unfortunately, this was an observation study so no information on effective dose can be deduced.

    http://www.ncbi.nlm.nih.gov/pubmed/11470724

    "...CONCLUSIONS: Aspirin use is associated with lower SF. We suggest this effect results from possible increased occult blood loss and a cytokine-mediated effect on SF in subjects with inflammation, infection, or liver disease. The relations between aspirin, inflammation, and SF may confound epidemiologic associations between elevated SF, as an indicator of iron stores, and heart disease risk."
     
  2. NathanK

    NathanK Member

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    Another gem... thank you
     
  3. Ledo

    Ledo Member

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    From the 2001 study conclusion:

    "We suggest that one possible way to eliminate potential confounding by aspirin use in epidemiologic studies of SF and chronic disease is to include only those subjects with an undetectable CRP as determined by an ultrasensitive CRP assay. To our knowledge, this has not been done in any of the prospective studies examining the association between elevated SF concentrations and risk of MI"

    So is iron being lowered by aspirin use or just SF reflective of inflammation AND do both or just one ( iron or inflammation) matter as they pertain to chronic disease?
     
  4. messtafarian

    messtafarian Member

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    This is problematic with my low iron. I've been taking it to manage inflammation but maybe it's not a good idea if that's true.
     
  5. OP
    haidut

    haidut Member

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    Low ferritin means low iron stores. Whether that means lower inflammation is not always clear but testing CRP and ESR would tell you that. In general, the lower the ferritin the lower inflammation since iron plays such a prominent role in inflammatory reactions.
     
  6. Douglas Ek

    Douglas Ek Member

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    Hi!
    I used to have low Iron and ferritin and experienced a lot of fatigue. Now my ferritin is between 100-150 and i feel fine. But everytime I take even a single dose of say 300mg aspirin after half a day or next day i get the same fatigue symptoms as when I had low iron. Its more like a mental tiredness than fatigue in the body. Could this be the reason and could aspirin some how even disrupt iron metabolism that quickly? Id like to take aspirin now and then just for the health benefits but i really cant without it causing the fatigue. And if I supplement iron same day as the aspirin the fatigue doesnt occur. Wondering if im just really sensitive or have a big need for iron. Thanks in advance for you thoughts!

    Ps also notice if i take bigger doses aspirin before bed i wake up with lots of coagulated blood in my nose. If I dont take aspirin and supplement vitamin K2 i never get this. Could a vitamin K deficiency cause anemia?
     
  7. OP
    haidut

    haidut Member

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    I doubt just 300mg aspirin would cause iron depletion to the point of causing fatigue. More likely, if aspirin lowers FFA and you don't have much glycogen stored in the liver then that could cause fatigue as the body will not have much fuel to go on. The blood in the nose is a sign of too much aspirin and a need for vitamin K. I would switch to aspirin maybe 2-3 times a week and taken with vitamin K. I don't know if vitamin K can cause anemia but I know of human case studies where vitamin K raised RBC and hemoglobin values.
     
  8. Douglas Ek

    Douglas Ek Member

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    Ok thanks for your reply!
     
  9. Kray

    Kray Member

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    Does your comment about vitamin K mean than too much could cause or contribute to iron overload?
     
  10. Kray

    Kray Member

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    Does your comment about vitamin K mean that it can cause iron levels to rise?
     
  11. OP
    haidut

    haidut Member

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    Not aware of any such effects of vitamin K. Just because it opposes aspirin's effects on coagulation does not mean it will oppose its effects on ferritin too.
     
  12. Kray

    Kray Member

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    Ok, thanks.
     
  13. Douglas Ek

    Douglas Ek Member

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    If it can oppose coagulation it could obviously lead to increased iron retention. More bleeding equalls bigger loss of blood which contains iron. It could probably help retain blood and increase hemoglobin.
     
  14. OP
    haidut

    haidut Member

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    True, but aspirin's iron lowering effect goes beyond bleeding. It can directly chelate it. I don't think vitamin K opposes that effect.
    Aspirin Chelates Iron
     
  15. Kray

    Kray Member

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    Aha- that gets to the point I was questioning. If one is considering aspirin for its iron-chelating benefits, vitamin K won't counteract that function.
     
  16. LucH

    LucH Member

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    Aspirin, salicine from white willow bark, and curcumine may also lower platelet agregation (and hemoglobin level), even when your ferritin level is high (> 200).
     
  17. lvysaur

    lvysaur Member

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    I have noticed a very specific red meat craving when I take aspirin. Usually I just crave meat regardless of type, and sometimes even find red meat to be too "heavy".
     
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