• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

haidut

Member
Joined
Mar 18, 2013
Messages
18,182
Location
USA / Europe
The so-called JK inhibitor drugs are all the rage right now for a number of chronic inflammatory conditions including IBD, RA, Lupus, MS, cancer and Alzheimer. This study found that aspirin (salicylic acid) is a potent JK inhibitor and as such relevant for all the conditions mentioned above. Not that we did not know it already but it adds another piece of the puzzle about aspirin's mechanisms of action.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling | Science Signaling
https://www.sciencedaily.com/releases/2016/11/161109112849.htm

"...Janus kinase (JAK) proteins -- named after the ancient Roman two-faced god -- are involved in controlling inflammation in certain tissues. They act like gatekeepers at the surface of cells, reacting to signals released by the immune system and transmitting these messages inside the cell. These Janus kinase proteins, however, can also carry mutations that make them faulty so they are permanently turned on and become overactive. A fault like this in Janus kinase 1 (JAK1) has been found to occur in several diseases. Professor Palmer and his colleagues have found another protein, known as AMP-activated protein kinase (AMPK), is able to turn JAK1 off -- even when it is faulty. According to their findings, published in the journal Science Signaling, it does this by chemically altering two key amino acids in the JAK1 protein in a process called phosphorylation. They also showed metformin and salicylate can activate AMPK so it turns off JAK1 in this way."
 

Xemnoraq

Member
Joined
Oct 3, 2016
Messages
154
Age
25
This interesting because i was doing some research on crohns disease and some work i came across mentioned that jk inhibitors were very effective and ironically enough i came across this post
 
Similar threads
Thread starter Title Forum Replies Date
T Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity Scientific Studies 1
Mr.Cacciatore Coffe, Aspirin and Iron Diet 2
GuiCHE Strange case on aspirin Ask For Help or Advice 19
rothko Health Natura Caffeine and Aspirin Water Solubility? Ask For Help or Advice 2
P Does Idealab Has Potassium and Aspirin? Supplements, Pharmaceutical Drugs 1
P New anti-aspirin study for those 60 and older Health 24
SOMO Have Blood Clot in my Lung + Leg - How effective is Aspirin/K2 really? Ask For Help or Advice 16
aliml Aspirin was the most potent life-extension agent when data for all model organisms was combined, more so than rapamycin or metformin Scientific Studies 31
A Does Niacinamide/Aspirin mitgate beneficial effects of SAT FAT Diet 1
R Aspirin rage Mental Issues 6
M Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury Supplements, Pharmaceutical Drugs 0
M Aspirin causing constipation and heartburn? Ask For Help or Advice 2
W Methylene Blue & Aspirin Sources Supplements 7
G Aspirin Yesterday...Salt Today Ask For Help or Advice 3
T New Aspirin Recommendations Aspirin 19
A Aspirin could protect the lungs of COVID-19 patients, minimize the need for mechanical ventilation, according to new research at George Washington U. Scientific Studies 0
F So will aspirin hinder fat loss or not when you hypometabolic??? Ask For Help or Advice 0
haidut PUFA required for periodontal disease, aspirin may help Scientific Studies 12
J Anti-Peat Danny Roddy's aspirin video, Worst of the hair loss industry Debate - Anti-Peat 12
Doludolu Extra "ingredients" in Aspirin & Magnesium Aspirin 9
N Natural versus synthetic aspirin ? Health 5
G When dissolving aspirin Ask For Help or Advice 29
F Is 5g aspirin daily safe in long term? Ask For Help or Advice 17
aliml Real-world evidence for improved outcomes with Famotidine and Aspirin in 22,560 COVID-19 patients Scientific Studies 4
Kaktos Losartan alongside aspirin? Safe for a few days? Supplements, Pharmaceutical Drugs 0
G Vit K mk7 dosages if aspirin is being supplemented? Ask For Help or Advice 3
eat my peat High dose aspirin for costochondritis? Health 23
haidut Aspirin reduces symptom severity, COVID-19 mortality by half Scientific Studies 12
A Where to buy aspirin online in Spain Supplements, Pharmaceutical Drugs 2
OccamzRazer Putting aspirin solution in bloodshot eye? Eyes, Ears, Nose and Headaches/Migraines 8
Mito Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Aspirin 6
G Aspirin kills libido Ask For Help or Advice 16
JudiBlueHen Anybody familiar with the new aspirin called Vazalore? Supplements, Pharmaceutical Drugs 4
Lizb Aspirin. Blood in urine - male Ask For Help or Advice 2
G Aspirin and Androgens Compilation (Anti-Peat-ish) Scientific Studies 6
Lenny Vitamin K and aspirin, how to proceed? Ask For Help or Advice 8
Jam Aspirin Use is Associated with Decreased Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis Scientific Studies 4
G Can you split gericare aspirin? Ask For Help or Advice 2
S Anyone else fine aspirin moreish? Ask For Help or Advice 1
T Mixing Aspirin + Baking soda Aspirin 17
haidut Air pollution impairs cognition, aspirin is protective Scientific Studies 2
F Can i somehow increase ph of aspirin? Ask For Help or Advice 3
F Increasing Aspirin ph? Ask For Help or Advice 3
D Aspirin can prevent the depletion of PUFA Aspirin 35
M Is white willow bark a good substitute for aspirin dosing? Ask For Help or Advice 5
A Aspirin and NSAIDs inhibit protein synthesis? Aspirin and bodybuilding Diet 4
A Peating and new to aspirin Diet 4
S Aspirin’s benefits never last for me...why? Supplements, Pharmaceutical Drugs 8
F Good aspirin source in the UK? Ask For Help or Advice 30
UseYourDelusion What, if any, effect does aspirin have on ketosis? Supplements, Pharmaceutical Drugs 0

Similar threads

Top