- Sep 28, 2016
Head twitches in rats can be used to study 5-HT neuronal activity. Several drugs induce these in rats, i.e. 5- hydroxytryptophan (5-HTP) by increasing free concentration of 5-HT at its receptor site or 5-methoxytryptamine by directly mimicking endogenous 5-HT at its receptor sites. Head twitches also occur in rats treated with lithium chloride and constitutes an useful animal model for quantifying 5-HT activity in the brain and screening of potential antagonists of 5-HT receptors.
Evidences suggest that serotonergic transmission inhibits the working memory performances and it is also suggested that blocking serotonergic transmission in brain is a possible mechanism to enhance the working memory performance