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Aspirin Has Nootropic Properties Via Serotonin Inhibition



WoW...great @Constatine:

"Inhibition of the serotonergic transmission by aspirin is responsible for its nootropic and neuroprotective actions."


Aug 29, 2013
I wonder if the effects would be greater or lesser with higher amounts, than say about 40mg for someone my weight.


Jun 7, 2017
It's interesting that they discuss the role of 5-HT in causing head twitches and poor memory, which is likely due to an excited, low-energy state, and are basically the hallmarks of dementia.
Head twitches in rats can be used to study 5-HT neuronal activity. Several drugs induce these in rats, i.e. 5- hydroxytryptophan (5-HTP) by increasing free concentration of 5-HT at its receptor site or 5-methoxytryptamine by directly mimicking endogenous 5-HT at its receptor sites. Head twitches also occur in rats treated with lithium chloride and constitutes an useful animal model for quantifying 5-HT activity in the brain and screening of potential antagonists of 5-HT receptors.
Evidences suggest that serotonergic transmission inhibits the working memory performances and it is also suggested that blocking serotonergic transmission in brain is a possible mechanism to enhance the working memory performance

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