Aspirin for tendinopathy

[KwirMaster]

Hello, first post for me, i wanted to share these studies with people here suffering from tendinopathy :

Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway​

Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway - PubMed

Tendinopathy is a common musculoskeletal system disorder in sports medicine, but regeneration ability of injury tendon is limited. Tendon stem cells (TSCs) have shown the definitive treatment evidence for tendinopathy and tendon injuries due to their tenogenesis capacity. Aspirin, as the...

pubmed.ncbi.nlm.nih.gov

Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway​

Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway - PubMed

Taken together, the findings suggested that aspirin inhibited inflammation and scar formation via regulation of JNK/STAT-3 signalling and decreased rerupture risk of injury tendon. Aspirin could be an ideal therapeutic strategy in tendon injury healing.

pubmed.ncbi.nlm.nih.gov

Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling​

Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling - PubMed

Tendon injury repairs are big challenges in sports medicine, and fatty infiltration after tendon injury is very common and hampers tendon injury healing process. Tendon stem cells (TSCs), as precursors of tendon cells, have shown promising effect on injury tendon repair for their tenogenesis and...

pubmed.ncbi.nlm.nih.gov

I am myself dealing with this type of injury, and aspirin seems to work (at least in my experience).

Good Luck!

 

[Prota]

Nice KM!
Thank's!

 

[spanner]

I have foot pain. Plantar fasciitis and/or whatever. I would wake up with foot pain and stiffness, and I’d have burning pain in plantar fascia (arch of foot) after exertion.

In the last week I started taking 650mg of aspirin daily.

Without thinking about it, the foot pain has mostly gone away.
Yesterday I went on a long walk as part of a hunting trip and hiked up a very steep hill, maybe 500 feet with a 45 degree incline. Midway up, my feet started to burn; I focused on avoiding flat footed locomotion or standing, continued climbing and … the pain went away. I didn’t think much of it at the time but usually when such burning would start it would not just go away, not rapidly and not with ongoing exertion.
Is it due to the aspirin? I don’t know but this is a definite improvement. My feet feel good this morning even after all of yesterday’s walking. I have aspirin before and after lunch so I’m not “on it” at the moment.

For my whole life, I have generally avoided pain killers including aspirin, so taking this much daily is new to me.

 

[KwirMaster]

Nice KM!
Thank's!

No problem!

 

[KwirMaster]

I have foot pain. Plantar fasciitis and/or whatever. I would wake up with foot pain and stiffness, and I’d have burning pain in plantar fascia (arch of foot) after exertion.

In the last week I started taking 650mg of aspirin daily.

Without thinking about it, the foot pain has mostly gone away.
Yesterday I went on a long walk as part of a hunting trip and hiked up a very steep hill, maybe 500 feet with a 45 degree incline. Midway up, my feet started to burn; I focused on avoiding flat footed locomotion or standing, continued climbing and … the pain went away. I didn’t think much of it at the time but usually when such burning would start it would not just go away, not rapidly and not with ongoing exertion.
Is it due to the aspirin? I don’t know but this is a definite improvement. My feet feel good this morning even after all of yesterday’s walking. I have aspirin before and after lunch so I’m not “on it” at the moment.

For my whole life, I have generally avoided pain killers including aspirin, so taking this much daily is new to me.

I believe it is! Aspirin definitely improved the burning sensation for me as well, and I feel like my joints are more functional.
I also use vitamin C (antioxidant properties, collagen synthesis in the tendon) + vitamin K, gelatin and bag breathing for the increased CO2.

 

[aguilaroja]

Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling

Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling - PubMed

Tendon injury repairs are big challenges in sports medicine, and fatty infiltration after tendon injury is very common and hampers tendon injury healing process. Tendon stem cells (TSCs), as precursors of tendon cells, have shown promising effect on injury tendon repair for their tenogenesis and...

pubmed.ncbi.nlm.nih.gov

I am myself dealing with this type of injury, and aspirin seems to work (at least in my experience).

Glad to hear of the improvement.

In the commerce-driven research, aspirin continues to be lumped in the NSAIDs, non-steroidal anti-inflammatory pharmaceuticals like ibuprofen and others.
Dr. Peat has, for decades, carefully distinguished between unique properties of aspirin, apart from the lucrative NSAID category. Many of these other so-called improved anti-inflammatory drugs remain under patent, in different forms.

Many aspirin actions remain importantly different from profitable drugs lumped into an associated category. Aspirin also remains cheaper plus more accessible.