Aspirin Cause Antiserotonine Effect Only At Low Doses (My Vision of the Non-Linear Dose-Dependent Antiserotonin Effect of Aspirin)

[NewACC]

Dear peats!
As you all know, serotonin has a direct aggregative coagulant effect through the 5-ht2 family of receptors. And so, aspirin has the strongest antiplatelet effect at doses below 325 mg.
We also know that aspirin has the most potent beneficial effect on tyrosine hydroxylase at a concentration of 2μ‎M. Does this mean that the antiserotonin effect of aspirin will not extend to its uncoupling effect, since this effect is achieved at a concentration of 0.5mM, which, for a moment, is 250 times greater, and will only occur at the most strongly blood-thinning doses?



@haidut

@Lokzo

@Hans

 

[NewACC]

I'm sorry for copying!

 

[catharsis]

Dear peats!
As you all know, serotonin has a direct aggregative coagulant effect through the 5-ht2 family of receptors. And so, aspirin has the strongest antiplatelet effect at doses below 325 mg.
We also know that aspirin has the most potent beneficial effect on tyrosine hydroxylase at a concentration of 2μ‎M. Does this mean that the antiserotonin effect of aspirin will not extend to its uncoupling effect, since this effect is achieved at a concentration of 0.5mM, which, for a moment, is 250 times greater, and will only occur at the most strongly blood-thinning doses?

View attachment 38903

@haidut

@Lokzo

@Hans

Low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production in dopaminergic neurons: Implications for Parkinson’s disease

A simple practice guide for dose conversion between animals and human

So attached above is the paper you are referencing and below it is another to calculate HED from an animal dose. It is hard to convert in-vitro studies into an accurate human oral dose of a compound (@haidut I think has shown it before but I need to double check how he did it). A bit later in the paper, they report results after dosing the mice 2mg/kg of aspirin, this will come out to about 0.1626mg/kg for humans or about 13mg for a 80kg human. Seems quite small of a dose to me as I take about 4 or 5 325mg tablets a day.

You are right that uncoupling doses will not affect TH concentration (pro-dopamine effect); but possibly towards the end of aspirin's circulation in the body, you might be able to get the TH upregulation. Aspirin might do other things to serotonin and its receptors; TH isn't the only thing you can view for aspirin's pro-dopamine, anti-serotonin effect.

 

[LeeLemonoil]

Is in line with my anecdotal experience and feeling.
Small dose aspirin (half a 300mg tablet for convinient halving of it) give me the most distinct mood boost.

Interesting that one of the most widely prescribed med and doses in geronts (100mg for „heart protection“) is countering quite some aspects of the usual Pharma-poisons that are as widely prescribed. No wonder the lobbying against it in recent years

 

[Orome]

Is in line with my anecdotal experience and feeling.
Small dose aspirin (half a 300mg tablet for convinient halving of it) give me the most distinct mood boost.

Interesting that one of the most widely prescribed med and doses in geronts (100mg for „heart protection“) is countering quite some aspects of the usual Pharma-poisons that are as widely prescribed. No wonder the lobbying against it in recent years

Exactly this. Even if only a little bit of the NWO / Great Reset agendas are true then they have to do something about aspirin, like regulating it and making it a prescription drug. If this does not work fearporn is the next best option. And we know that the latter is in the making since quite some time now. When a coworker or family member asks me if I have a painkiller and I come up with aspirin they look at me as if I offered them cannabis or something. They are scared of it and would always opt for ibuprofen.
I have been taking aspirin regular for almost 15 years now and I am convinced that it has played a big part in my current state of health. Also I never had noticable bleeding episodes.

 

[NewACC]

Low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production in dopaminergic neurons: Implications for Parkinson’s disease

A simple practice guide for dose conversion between animals and human

So attached above is the paper you are referencing and below it is another to calculate HED from an animal dose. It is hard to convert in-vitro studies into an accurate human oral dose of a compound (@haidut I think has shown it before but I need to double check how he did it). A bit later in the paper, they report results after dosing the mice 2mg/kg of aspirin, this will come out to about 0.1626mg/kg for humans or about 13mg for a 80kg human. Seems quite small of a dose to me as I take about 4 or 5 325mg tablets a day.

You are right that uncoupling doses will not affect TH concentration (pro-dopamine effect); but possibly towards the end of aspirin's circulation in the body, you might be able to get the TH upregulation. Aspirin might do other things to serotonin and its receptors; TH isn't the only thing you can view for aspirin's pro-dopamine, anti-serotonin effect.

It would be quite interesting to learn how to convert doses in vitro to in vivo

 

[NewACC]

I also have an assumption that the antiplatelet effect of aspirin follows its antiserotonin effect, which I stated in my post, since serotonin directly increases platet aggregation

 

[cs3000]

That rat study showed profound dopamine / tyrosine hydroxylase upregulation response on ~10mg aspirin human dose orally by 30 days. And their activity levels went up a lot so it's a functional effect

This one as far as I can tell https://www.researchgate.net/figure...hanged-during-aspirin-exposure_tbl2_264010868
in humans suggests serotonin actually goes up with 81mg dose? But rat study 1g equivalent showed it blocked serotonergic effects so maybe elevation alone isn't as relevant , or changes at really high or really low dose

They say in the human study higher serotonin effect correlated with higher platelet aggregation, but serotonin went up a bit

to me microdosing 10mg-15mg looks like the way to go in terms of pro dopamine / anti serotonin. that's still high in food terms

 

[sunny]

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[catharsis]

I also have an assumption that the antiplatelet effect of aspirin follows its antiserotonin effect, which I stated in my post, since serotonin directly increases platet aggregation

I agree completely. I am not sure if it is a one to one relationship but they are intimately tied.

 

[BRMarshall]

This is interesting and certainly micro-dosing aspirin is something to experiment with...since I have experimented with chomping it to the tinnitus threshold once of twice...

I do not know if aspirin ever really made noticeable effects on pain for me, but I do think that it might have had helped foster euphoric states; but this is but a guess that with other good chemistry going, a bit of keeps a certain flow going...though i can estimate any guess other than the standard two.