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PeatThemAll
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Aspirin intake impact on uric acid levels.
http://www.ncbi.nlm.nih.gov/pubmed/10643705
Full text (PDF) at: IMAJ - Renal Effects of Low Dose Aspirin in Elderly Patients
http://www.ncbi.nlm.nih.gov/pubmed/10643705
Abstract
Background:
Aspirin is commonly used by elderly patients.
In previous studies we found transient changes in renal function
induced by low doses of aspirin.
Objectives:
To investigate the mechanisms of these effects.
Methods:
The study group included 106 long-term care stable
geriatric inpatients. Diet and drugs were kept stable. The study lasted
5 weeks; during the first 2 weeks 100 mg aspirin was administered
once a day. Clinical and laboratory follow-up was performed at
baseline and weekly for the next 3 weeks. The glomerular filtration
rate was estimated by creatinine clearance measured in 24 hour
urine and serum creatinine, and by the Cockcroft-Gault formula
(C-G) equation. Uric acid clearance was determined from serum
concentrations and 24 hour excretion of uric acid. Patients with
serum creatinine > 1.5 mg/dl were not included.
Results:
After 2 weeks on low dose aspirin, measured creatinine
and uric acid clearances decreased significantly compared with
the initial values in 70% and 62% of the patients, respectively, with
mean decreases of 19% and 17%, respectively (
P
< 0.001). Blood
urea nitrogen increased by 17% while serum creatinine and uric
acid concentrations increased by 4% (
P
< 0.05 for all). The C-G
values decreased by 3% (
P
< 0.05). After withdrawal of aspirin all
parameters improved. However, 67% of the patients remained with
some impairment in their measured Ccr, compared to baseline.
Patients who reacted adversely to low dose aspirin had significantly
better pre-study renal function (Ccr), lower hemoglobin and lower
levels of serum albumin.
Conclusions:
Short-term low dose aspirin affected renal tubular
creatinine and uric acid transport in the elderly, which may result
in a prolonged or permanent deterioration of the renal function. It
is suggested that renal functions be monitored even with the use
of low dose aspirin in elderly patients
Full text (PDF) at: IMAJ - Renal Effects of Low Dose Aspirin in Elderly Patients