Aspirin Actually Lowers Risk Of Bleeding In The Brain

Discussion in 'Scientific Studies' started by haidut, May 21, 2015.

  1. haidut

    haidut Member

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    This should study should be a required reading for all doctors who mindlessly parrot about aspirin and bleeding risks. In fact, the purported brain bleeding has been used the main reason for not recommending preventive aspirin usage for all age groups at risk for degenerative conditions. Btw, I already posted a study showing aspirin use decreased GI bleeding risks and its associated mortality.
    According to this study, aspirin use may actually treat brain aneurisms and if anything, it decreases the risk of brain bleeding associated with those aneurisms.

    http://www.ncbi.nlm.nih.gov/pubmed/25967073

    "...Key Messages: Aspirin has been found to be a safe in patients harboring cerebral aneurysms and clinical studies provide evidence that it may decrease the overall rate of rupture. Furthermore, aspirin is an accessible and inexpensive medicine for patients who may not have access to endovascular or microsurgical treatment or for patients who are deemed low risk of aneurysm rupture, high risk for intervention, or both. Future clinical trials are indicated to determine the overall effect of aspirin on aneurysm progression and rupture. This review provides an update on the potential mechanisms and benefits of aspirin in the treatment of cerebral aneurysms."
     
  2. Peata

    Peata Member

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    This floors me. This was one of the reasons I was hesitant to take aspirin regularly, and some of my family as well. It might have made a big difference for one family member if they hadn't been scared off by their doctor about taking it.
     
  3. jyb

    jyb Member

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    Hum, but without doubt aspirin can make people nose bleed (unless one is carefully supplementing K2). This has happened to me very consistently with aspirin (when I didn't do a good K2 supplementation). And it takes more time for coagulation around a cut. So why wouldn't it happen elsewhere internally in the body? It's pretty well understood that aspirin depletes the body's K2, so from where you can imagine...
     
  4. OP
    haidut

    haidut Member

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    I hear you, and do agree that it sound for logical for aspirin to increase bleeding event. However, the two human studies I posted found the exact opposite in cases of GI and brain bleeding - the two main reasons cited by doctors for not recommending aspirin. Maybe bleeding would be related to weakened vessel walls, which is usually caused by estrogen, and probably blocked by aspirin. So, the nose bleeds you have may disappear eventually as aspirin does its magic on the vessel.
     
  5. OP
    haidut

    haidut Member

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    And here is the other thread to floor you even more:):
    viewtopic.php?f=10&t=6158
     
  6. jyb

    jyb Member

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    The bleeding in my case with aspirin seemed very clearly related to its K2 depleting effect. Supplement enough K2 would stop it within the same day, it's very striking.

    And this reminds me of a study you posted on aspirin not good before physical exercise. I wouldn't be surprised if it were related to that, since it seems so easy to bleed if you didn't supplement K2.
     
  7. jyb

    jyb Member

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    However, for short term low dose, or if K2 is supplemented, then the effect on blood could be good as Peat wrote about. I just commented because its not crazy to think it *could* make you bleed in many cases.
     
  8. mas

    mas Member

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    Thank you Haidut for all of the scientific data that you compile because this data gives scientific credibility and a valuable reference source to this forum.

    For a while, the use of low dose aspirin was advocated by some doctors , but unfortunately, now media spin is heading off into the aspirin “danger” arena again.

    http://www.wsj.com/articles/SB100014240 ... 1363436686

    Unfortunately, the public will be duped again because of the fake media bits. Like Ray said, any study can be set up to provide any conclusion that they want and people see a distorted article about aspirin being dangerous instead of reading the real science as Haidut has presented.

    I wonder if using aspirin for one week and stopping and cycling like this would work. I guess it just comes down to each person’s experience. I want to take enough for healing purposes but not too much and I just keep on adjusting as to my own observations.

    I think that the bleeding/clotting systems are complex and many factors such as estrogen, serotonin, fibrin, etc…are involved and many people have bleeding events without aspirin.

    ____________________________________

    http://raypeat.com/articles/aging/bleeding-clotting-cancer.shtml

    When fibrin is destroyed faster than it can be replaced, blood vessels become too permeable, and bleeding can occur more easily.
     
  9. sladerunner69

    sladerunner69 Member

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    I definitely experienced bleeding/stomach upsets when first utilizing aspirin at about 500mg each day. My system gradually adapted along with vit k supplementaion. I personally can understand the hesitation to slow down on aspirin intake, it doesnt seem to be as straight foward a solution as many make it seem and will require careful, gradual optimization.
     
  10. David Chung

    David Chung Member

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    This is interesting, because, to me, the study suggests to me that a drug can have different effects depending on the condition of the body.

    Since aspirin thins blood, when taken, there would be less chance of occlusion. This explains why the capillaries in the brain are less likely to burst with aspirin use.

    In contrast, the type of aspirin-related GI bleeding that people refer to is caused by COX inhibition. Due to the inhibition, stomach lining fails to produce proper mucous. I know that the body fights NSAID effects, and so it would not be surprising if the GI's some users acclimated to aspirin use. In fact, it is possible that the adaptation may lead to LESS bleeding over time (compared tothose not taking aspirin).
     
  11. jb116

    jb116 Member

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    This wasn't clear to me, what were you trying to say here? "... so it would not be surprising if the GI's some users acclimated to aspirin use"

    Also, regarding COX, specifically COX-1 which is responsible for mucous lining, I've always found this to be a conundrum for those who have GI issues if considering aspirin.
    So what is the solution there?
     
  12. Peata

    Peata Member

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    Just wondering if you still take aspirin and K2. How much aspirin do you take?

    I used to take it without K2, but wasn't consistently taking large amounts daily, more like small amount regularly with occasional large dose use (mostly for pain). Never had bleeding issues with it. Over the last month or two, I've increased aspirin to where I take it most days, at least 325 mg, often 4 - 7 aspirin (usually just days I work as I'm prone to headaches on job, plus I think the aspirin helps with water retention, cortisol, and thinking). Been using 5 mg. K2. I wonder if it's too much K2 because cuts stop bleeding fast and heal up. Not sure if it's "too fast" for the amount of aspirin I'm taking. Guess it goes to show that 5 mg K2 is enough for more than 5 aspirin (for me).
     
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