Ascorbic Acid as an antidote to balding?

reality

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Besides all the benefits of ascorbic acid that could counter a lot of problems with hair loss (cortisol, CVD, etc), one of ascorbic acid's metabolites is L threonate, which is a potent Dkk1 inhibitor and implicated in balding


In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate. We also found that DHT-induced activation of DKK-1 promoter activity was significantly repressed by L-threonate. Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate. Collectively, these results indicate that L-threonate inhibited DKK-1 expression in DPCs and therefore is a good treatment for the prevention of androgen-driven balding.

thoughts on this?
 
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It's easy enough to try.

Personally I can't handle high dose ascorbic acid (above 1 g) or else I get ball ache, like with most antioxidants.
I tried topical ascorbic, similar thing happens. Threonate gives me nerve pain in my legs.

Tianeptine can also inhibit DKK-1, but I don't know if you can use a safe dose that won't get you addicted. The usual one (3x 12.5 mg) probably isn't enough. Haven't tried that topically.
 

reality

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It's easy enough to try.

Personally I can't handle high dose ascorbic acid (above 1 g) or else I get ball ache, like with most antioxidants.
I tried topical ascorbic, similar thing happens. Threonate gives me nerve pain in my legs.

Tianeptine can also inhibit DKK-1, but I don't know if you can use a safe dose that won't get you addicted. The usual one (3x 12.5 mg) probably isn't enough. Haven't tried that topically.
Interesting

I’ve been taking 2-4g a day recently and it definitely improves my mood so I’m sticking with it

I have used tianeptine years ago and it was a good antidepressant but I’m not going down that route again
 
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Interesting

I’ve been taking 2-4g a day recently and it definitely improves my mood so I’m sticking with it

I have used tianeptine years ago and it was a good antidepressant but I’m not going down that route again

2-4g of Vitamin C?

At that dose I think you should be seeing some kind of positive effect on your hair. At the very least slowed down hair loss.
 

reality

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2-4g of Vitamin C?

At that dose I think you should be seeing some kind of positive effect on your hair. At the very least slowed down hair loss.
Yeah pure ascorbic acid (quali c). It has huge amount of benefits from what I’ve researched, so I’m hoping the dkk1 inhibition could be helpful

my hair is still in good condition but I deffo have mpb so I’m looking to halt it as much as possible
 
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