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The human gut microbiome is a community of more than 10 trillion microbial cells from about 1,000 different bacterial species, and transkingdom network analysis integrates multiple types of “omics” data – metagenomic, metabolomic, lipidomic, proteomic, etc. – in determining how interactions among specific types of gut microbes help or hinder biological functions in the host.
In this case, the microbial interactions involved how well the body responds to a type of cancer treatment known as anti-programmed cell death protein therapy, abbreviated to anti-PD-1 therapy. It allows immune cells to react more strongly to cancer.
“It was pretty dramatic,” said Morgan, associate professor of pharmaceutical sciences. “We found altering the gut microbiome can take a patient with advanced melanoma who has never responded to immunotherapy, which fails about 60% of the time with this kind of cancer, and convert the patient into one who responds to it.”
theworldlink.com
In this case, the microbial interactions involved how well the body responds to a type of cancer treatment known as anti-programmed cell death protein therapy, abbreviated to anti-PD-1 therapy. It allows immune cells to react more strongly to cancer.
“It was pretty dramatic,” said Morgan, associate professor of pharmaceutical sciences. “We found altering the gut microbiome can take a patient with advanced melanoma who has never responded to immunotherapy, which fails about 60% of the time with this kind of cancer, and convert the patient into one who responds to it.”
Melanoma patients respond to immunotherapy after changes to gut microbiome
Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients’ gut microbiome led them to respond to a type of treatment capable of providing long-term
