Aromatization Of Androgens To Estrogens Mediates Increased Activity Of G6PDH

[Drareg]

Danny Roddy was writing about G6PDh and baldness, how increasing it is beneficial in some cases.

Does anybody know what to make of this study? Claims estrogen increases G6PDH.


Abstract
Administration of testosterone propionate to immature male rats caused a 50% increase in the specific activity of glucose 6-phosphate dehydrogenase, the rate-limiting enzyme of the pentose phosphate pathway, in the levator ani muscle. This effect appears to be mediated by conversion of testosterone to estradiol because of the following results: 1) the effect was not mimicked by the nonaromatizable androgens fluoxymesterone or 5 alpha-dihydrotestosterone; 2) it was mimicked by 17 beta-estradiol and diethylstilbestrol; 3) it was blocked by an estrogen antagonist but not by an androgen antagonist; 4) the inactive steroid 17 alpha-estradiol was without effect on glucose 6-phosphate dehydrogenase; and 5) the effect of testosterone was blocked by an inhibitor of androgen aromatase. These results demonstrate a direct effect of estrogen on striated muscle.


Aromatization of androgens to estrogens mediates increased activity of glucose 6-phosphate dehydrogenase in rat levator ani muscle. - PubMed - NCBI