Arginine Depletion May Be A Viable Approach For Cancer

[Xisca]

Here is a pdf list.
http://www.sandiegohomeopathy.com/downloads/Lysine_Arginine_Foods.pdf

Well, another reason not too eat nuts, they are high in arginine and low in lysine, their ratio is the worse! Grains and most legumes are not good, potatos are fine! Sweat potato and bananas are ok too.

Dairies and fish and then meats are the best.

Bad news for chocolate…

Snail, shrimps and crab are not balanced on the right side.

A drawback for skin and gelatine in general, it has not the right balance the meat has…
Orange might not have a lot, but the balance is pretty bad!

 

[ddjd]

Ray is not a big fan of certain amino acids like arginine due to its role as a nitric oxide (NO) precursor. I posted a study several weeks ago showing that supplemental arginine greatly boosted tumor growth while supplemental glycine halted it. This latest study seems to take the arginine depletion approach to its extreme and it is showing promising results.

http://www.neomatica.com/2014/08/21/chr ... -eats-dna/
Novel drug action against solid tumors explained

"...Scientists based in the U.S. at the University of California Davis, and in Taiwan at Taipei Medical University as well as the National Health Research Institutes have simultaneously discovered a new process of “chromatophagy” cellular suicide and shed light on the way a “starvation” drug deprives cancer cells of arginine, a necessary amino acid."

"...The drug examined in the study is ADI-PEG20, developed by Polaris Pharmaceuticals of San Diego. ADI-PEG20 is an enzyme that degrades arginine, which normally would be available to the cell, breaking it down into its precursors. The agent is currently in phase III clinical trials in liver cancer, phase II in melanoma and phase I in prostate cancer."

The drug ADI-PEG20 is nothing but the enzyme arginine deaminase (ADI) combined with polyethylene glycol (PEG). ADI converts arginine to citrulline and ammonia.
Arginine deiminase - Wikipedia, the free encyclopedia

Given the tumor promoting effects of ammonia on cancer, I wonder if safer methods of arginine depletion would be more viable. Cascara, niacinamide, methylene blue, and vitamin B12 should lower NO directly and provide the same benefit, since NO depletion is what the arginine depletion therapy seems to be relying upon for effectiveness.

This study shows that cascara sagrada's laxative effect works through inducing production of nitric oxide in the colon. More specifically, cascara induced 12 percent of nitric oxide synthase. The laxative affects of cascara were eliminated with an anti-nitric oxide agent. Should we be concerned about this?

The role of constitutive and inducible nitric oxide synthase in senna- and cascara-induced diarrhoea in the rat - PubMed

The role of constitutive and inducible nitric oxide (NO) synthase in rats treated with senna and cascara was studied. Senna (60 mg/kg p.o.) and cascara (800 mg/kg p.o.) ex vivo significantly increased Ca(2+)-dependent constitutive NO synthase activity in the rat colon. Induction of NO synthase...

pubmed.ncbi.nlm.nih.gov

 

[ddjd]

Ray is not a big fan of certain amino acids like arginine due to its role as a nitric oxide (NO) precursor. I posted a study several weeks ago showing that supplemental arginine greatly boosted tumor growth while supplemental glycine halted it. This latest study seems to take the arginine depletion approach to its extreme and it is showing promising results.

http://www.neomatica.com/2014/08/21/chr ... -eats-dna/
Novel drug action against solid tumors explained

"...Scientists based in the U.S. at the University of California Davis, and in Taiwan at Taipei Medical University as well as the National Health Research Institutes have simultaneously discovered a new process of “chromatophagy” cellular suicide and shed light on the way a “starvation” drug deprives cancer cells of arginine, a necessary amino acid."

"...The drug examined in the study is ADI-PEG20, developed by Polaris Pharmaceuticals of San Diego. ADI-PEG20 is an enzyme that degrades arginine, which normally would be available to the cell, breaking it down into its precursors. The agent is currently in phase III clinical trials in liver cancer, phase II in melanoma and phase I in prostate cancer."

The drug ADI-PEG20 is nothing but the enzyme arginine deaminase (ADI) combined with polyethylene glycol (PEG). ADI converts arginine to citrulline and ammonia.
Arginine deiminase - Wikipedia, the free encyclopedia

Given the tumor promoting effects of ammonia on cancer, I wonder if safer methods of arginine depletion would be more viable. Cascara, niacinamide, methylene blue, and vitamin B12 should lower NO directly and provide the same benefit, since NO depletion is what the arginine depletion therapy seems to be relying upon for effectiveness.

This study shows that cascara sagrada's laxative effect works through inducing production of nitric oxide in the colon. More specifically, cascara induced 12 percent of nitric oxide synthase. The laxative affects of cascara were eliminated with an anti-nitric oxide agent. Should we be concerned about this?

The role of constitutive and inducible nitric oxide synthase in senna- and cascara-induced diarrhoea in the rat - PubMed

The role of constitutive and inducible nitric oxide (NO) synthase in rats treated with senna and cascara was studied. Senna (60 mg/kg p.o.) and cascara (800 mg/kg p.o.) ex vivo significantly increased Ca(2+)-dependent constitutive NO synthase activity in the rat colon. Induction of NO synthase...

pubmed.ncbi.nlm.nih.gov