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mdimarco said:Interesting. Reading peatarian's minocycline comments and did a little research on it and I think it is a good idea.
Bacterial resistance isn't a long term thing. Especially if you are cleaning out the majority of the bacteria in the body (which is in the intestines) mechanically, I think taking a safe antibiotic once every few months could be a great thing to get things in the skin, naso-pharengeal area, and other areas. Bacteria will take up genetic plasmids from other bacteria to allow them to make protiens that make them resistant to something. However, carrying these plasmids with them takes extra energy. Bacteria aren't dumb, once the threat passes, they will drop the plasmids, thereby loosing resistance. I know this first hand working with e-coli in my lab.
So I think an antibiotic course would be good, but no more than once a month so you aren't perpetuating any resistance developed. Obviously that timing isn't fine tuned, I think specific studies with minocycline or whatever we are taking needs to be done to see how long bacteria isolated from different parts of our body keep antibiotic resistance after the antibiotic leaves the system. It is an easy experiment, we would just need to transform different types of bacteria with minocycline resistance plasmid (likely easily available), get minocycline and make plates with it, grow the bacteria on the antibiotic plates, then grow for a certain number of times on normal plates, then receck to see if they can survive on the mino plates. We could find how long they carry the resistance gene once the threat is removed. This could be done in any biology lab.
Yves said:I've had a long list of problems like stuffy nose, headaches, insomnia, anxiety, depression, tmj, etc. and I wonder if it has to do with infections directly in that region of the body.
ER said:Dear Dr Peat,
what is your opinion on lactobacillus reuteri as a probiotic to reduce endotoxins? This strain produces the antibiotic reuterin and there's some evidence that it helps with bacterial infections.
Ray Peat said:I think it’s safe; I’ve seen good results from other bacterial cultures, such as B. subtilis and B. licheniformis
Dan Wich said:post 104284 Reviving this old thread with a quote from Peat that surprised me:
ER said:Dear Dr Peat,
what is your opinion on lactobacillus reuteri as a probiotic to reduce endotoxins? This strain produces the antibiotic reuterin and there's some evidence that it helps with bacterial infections.Ray Peat said:I think it’s safe; I’ve seen good results from other bacterial cultures, such as B. subtilis and B. licheniformis
Dan Wich said:Apparently Peat used Biosporin cultured in milk (or possibly something else). Biosporin contains the B. Subtilis and B. Licheniformis he mentioned.
Here's a warning about B. Subtilis that could be particularly relevant to Peat-peeps that might also use antibiotics.
Makrosky said:post 104338 But.... didn't he say that a sterile gut is the best gut? Why then does he recommend some non-mainstream probiotics ?
I don't always do probiotics. But when I do, they produce antibiotics
Makrosky said:post 104338 But.... didn't he say that a sterile gut is the best gut?