Are there any natural mao b inhibitors

Lostguy24

Member
Joined
Feb 28, 2020
Messages
100
I thought on taking avena sativa because of its mao b inhibition that raises dopamine but are there any mao b inhibitors like avena sativa that are stronger
 

aliml

Member
Joined
Apr 17, 2017
Messages
692

High throughput Screening to Identify Natural Human MAO-B Inhibitors​


Age-related increase in monoamine oxidase B (MAO-B) may contribute to CNS neurodegenerative diseases. Moreover, MAO-B inhibitors are used in the treatment of idiopathic Parkinson disease as preliminary monotherapy or adjunct therapy with L-dopa. To date, meager natural sources of MAO-B inhibitors have been identified, and the relative strength, potency and rank of many plants relative to standard drugs such as Selegiline (L-deprenyl, Eldepryl) are not known. In this work, we developed and utilized a high throughput enzyme microarray format to screen and evaluate 905 natural product extracts (0.025–.7 mg/ml) to inhibit human MAO-B derived from BTI-TN-5B1-4 cells infected with recombinant baculovirus. The protein sequence of purified enzyme was confirmed using 1D gel electrophoresis-matrix assisted laser desorption ionization-time-of-flight-tandem mass spectroscopy, and enzyme activity was confirmed by [1] substrate conversion (3-mM benzylamine) to H202 and [2] benzaldehyde. Of the 905 natural extracts tested, the lowest IC50s [<0.07 mg/ml] were obtained with extracts of Amur Corktree (Phellodendron amurense), Bakuchi Seed (Cyamopsis psoralioides), Licorice Root (Glycyrrhiza glabra/uralensis), Babchi (Psoralea corylifolia seed). The data also show, albeit to a lesser extent, inhibitory properties of herbs originating from the mint family (Lamiaceae) and Turmeric, Comfrey, Bringraj, Skullcap, Kava-kava, Wild Indigo, Gentian and Green Tea. In conclusion, the data reflect relative potency information by rank of commonly used herbs and plants that contain human MAO-B inhibitory properties in their natural form.


Natural plant sources of human MAO-B inhibitors​


LEVEL​
ID​
Common name​
Scientific name​
Inhibitory conc.​
LEVEL 1
A9​
Amur Cork Tree​
Phellodendron amurense
IC50 <.07 mg/ml​
B54​
Bakuchi Seed a
Cyamopsis psoralioides
IC50 <.07 mg/ml​
L2​
Licorice Root​
Glycyrrhiza glabra
IC50 <.07 mg/ml​
G22​
Gan Cao a
Glycyrrhiza uralensis root
IC50 <.07 mg/ml​
P58​
Psoralea Fruit Babchi a
Psoralea corylifolia
IC50 <.07 mg/ml​
LEVEL 2
P15​
Beefsteakplant a
Perilla frutescens leaf
IC50 <.2 mg/ml​
W4​
Black Pepper​
Piper nigrum
IC50 <.2 mg/ml​
B15​
Bringraj ‘False Daisy’​
Eclipta erecta
IC50 <.2 mg/ml​
C34​
Chinese arborvitae a
Truja, Platycladus orientalis twig/leaf
IC50 <.2 mg/ml​
C2​
Comfrey​
Symphytum officinale leaf
IC50 <.2 mg/ml​
C84​
Curry powder​
Coriander, turmeric, cumin, fenugreek, red pepper
IC50 <.2 mg/ml​
F4​
Figwort​
Scrophularia nodosa
IC50 <.2 mg/ml​
S54​
Gloryvine Stem​
Sargentodoxa cuneata
IC50 <.2 mg/ml​
XT3​
Green Tea​
Camellia sinensis
IC50 <.2 mg/ml​
H20​
Herb de province​
Oregano, thyme, savory, lavender, basil, sage, rosemary
IC50 <.2 mg/ml​
K8​
Kava Kava​
Piper methysticum
IC50 <.2 mg/ml​
L45​
Ladys’ Mantle​
Alchemilla vulgaris
IC50 <.2 mg/ml​
A37​
Lesser Galangal​
Alpinia officinarum Root
IC50 <.2 mg/ml​
L35​
Red Henna​
Lawsonia inermis
IC50 <.2 mg/ml​
C53​
Sappanwood​
Caesalpinia sappan wood
IC50 <.2 mg/ml​
D10​
Thick-stemmed Wooda
Dryopteris crassirhizoma
IC50 <.2 mg/ml​
T3​
Turmeric a
Curcuma Longa
IC50 <.2 mg/ml​
W13​
Watercress​
Nasturtium officinale
IC50 <.2 mg/ml​
W3​
Wild Indigo Root​
Baptisia tinctoria
IC50 <.2 mg/ml​
W10​
Wild lettuce​
Lactuca virosa
IC50 <.2 mg/ml​
G6​
Yellow Gentian Root​
Gentiana lutea
IC50 <.2 mg/ml​
LEVEL 3
A4​
Alfalfa​
Medicago sativa
IC50 >.2 <.4 mg/ml​
A48​
Alpinia​
Alpinia katsumadai seed
IC50 >.2 <.4 mg/ml​
B48​
Bay Leaf​
Laurus nobilis
IC50 >.2 <.4 mg/ml​
B13​
Bayberry Root bark a
Morella cerifera
IC50 >.2 <.4 mg/ml​
C103​
Cedar Berries​
Juniperus monosperma
IC50 >.2 <.4 mg/ml​
C101​
Celandine​
Chelidonium majus
IC50 >.2 <.4 mg/ml​
S56​
Common hedgenettle​
Stachys officinales
IC50 >.2 <.4 mg/ml​
E3​
Eucalyptus Leaf​
Eucalyptus globulus
IC50 >.2 <.4 mg/ml​
E6​
Eyebright​
Euphrasia officinalis
IC50 >.2 <.4 mg/ml​
D18​
Fringed Pink​
Dianthus superbus
IC50 >.2 <.4 mg/ml​
G31​
Garam Marsala​
Garam Marsala
IC50 >.2 <.4 mg/ml​
G28​
Gourmet pepper mill​
Gourmet pepper mill
IC50 >.2 <.4 mg/ml​
G29​
Gunpowder green tea​
Camellia sinensis
IC50 >.2 <.4 mg/ml​
H22​
Hyssop​
Hyssopus officinalis
IC50 >.2 <.4 mg/ml​
P89​
Indian long pepper​
Piper longum
IC50 >.2 <.4 mg/ml​
I2​
Isatis Leaf​
Isatis indigotica; Isatis tinctoria
IC50 >.2 <.4 mg/ml​
I8​
Italian spice herbal tea​
Italian spice herbal tea
IC50 >.2 <.4 mg/ml​
K9​
Kola Nut​
Cola acuminata
IC50 >.2 <.4 mg/ml​
L43​
Lemon Curry​
Lemon curry
IC50 >.2 <.4 mg/ml​
L49​
Lemon Verbana​
Aloysia triphylla
IC50 >.2 <.4 mg/ml​
M20​
Lilly Tree​
Magnolia denudata flower
IC50 >.2 <.4 mg/ml​
L46​
Linden Leaf​
Tilia europaea
IC50 >.2 <.4 mg/ml​
M38​
Maiden Hair Fern​
Adiantum capillus
IC50 >.2 <.4 mg/ml​
M40​
Motherwort​
Leonurus cardiaca
IC50 >.2 <.4 mg/ml​
P4​
Parsley​
Petroselinum crispum
IC50 >.2 <.4 mg/ml​
R4​
Red Clover​
Trifolium pratense
IC50 >.2 <.4 mg/ml​
R9​
Red Sandlewood​
Pterocarpus santalinus
IC50 >.2 <.4 mg/ml​
L33​
Rough bugleweed​
Lycopus lucidus
IC50 >.2 <.4 mg/ml​
S61​
Sage​
Salvia officinalis
IC50 >.2 <.4 mg/ml​
S23​
Sassafras​
Sassafras Albidum
IC50 >.2 <.4 mg/ml​
E21​
Scouringrush horsetail​
Equisetum Heimale
IC50 >.2 <.4 mg/ml​
S32​
Skull cap a
Scutellaria barbata
IC50 >.2 <.4 mg/ml​
S16​
Skull cap a
Scutellaria lateriflora
IC50 >.2 <.4 mg/ml​
S64​
Spearmint a
Mentha spicata
IC50 >.2 <.4 mg/ml​
S20​
Stevia/Candyleaf​
Stevia rebaudiana
IC50 >.2 <.4 mg/ml​
S15​
Szechuan pepper​
Zanthoxylum bungeanum
IC50 >.2 <.4 mg/ml​
W11​
White Sage​
Salvia apiana
IC50 >.2 <.4 mg/ml​
Y8​
Yohimbe Bark​
Corynanthe yohimbe
IC50 >.2 <.4 mg/ml​
Y7​
Young Hyson Green Tea​
Camellia sinensis
IC50 >.2 <.4 mg/ml​
V1​
Zi Hua Di Ding​
Viola yedoensis herb
IC50 >.2 <.4 mg/ml​
LEVEL 4
ID
Common Name
Scientific Name
Inhibitory Conc.​
A67​
Ancho chili pepers​
Capsicum annum
IC50 >.4 < .7 mg/ml​
B19​
Blackberry leaf​
Rubus fruticosus
IC50 >.4 < .7 mg/ml​
B12​
Blackberry Root​
Rubus fruticosus or Rubus Villosus
IC50 >.4 < .7 mg/ml​
F17​
Bladderwrack​
Fucus vesiculosus
IC50 >.4 < .7 mg/ml​
B26​
Blessed Thistle​
Cnicus benedictus
IC50 >.4 < .7 mg/ml​
C1​
California Poppy​
Eschscholzia californica
IC50 >.4 < .7 mg/ml​
C87​
Catnip a
Nepeta cataria
IC50 >.4 < .7 mg/ml​
H16​
Chameleon​
Houttuynia cordata herb
IC50 >.4 < .7 mg/ml​
c80​
Cilantro Leaf​
Coriandrum sativum
IC50 >.4 < .7 mg/ml​
C39​
Cinnamon Twig​
Cinnamomum cassia
IC50 >.4 < .7 mg/ml​
C9​
Cleavers​
Galium aparine
IC50 >.4 < .7 mg/ml​
A49​
Clematis trifoliata​
Akebia trifoliata fruit
IC50 >.4 < .7 mg/ml​
D1​
Damiana Leaf​
Turnera diffusa
IC50 >.4 < .7 mg/ml​
E24​
Earlgrey black tea​
Earlgrey black tea
IC50 >.4 < .7 mg/ml​
E23​
Elder berries​
Sambucus nigra
IC50 >.4 < .7 mg/ml​
E2​
Epidedium​
Epimedium grandiflorum
IC50 >.4 < .7 mg/ml​
E15​
Epidedium​
Epimedium koreanum
IC50 >.4 < .7 mg/ml​
F2​
Feverfew​
Tanacetum parthenium
IC50 >.4 < .7 mg/ml​
C17​
Garden Chervil​
Anthriscus cerefoilium
IC50 >.4 < .7 mg/ml​
G30​
German chamomile​
Matricaria recutita
IC50 >.4 < .7 mg/ml​
G37​
Goats Rue​
Galega officinalis
IC50 >.4 < .7 mg/ml​
G8​
Great Valley gumweed​
Grindelia camporum
IC50 >.4 < .7 mg/ml​
L3​
Gromwell root​
Lithospermum erythrorhizon root
IC50 >.4 < .7 mg/ml​
G4​
Gymnema​
Gymnema sylvestre
IC50 >.4 < .7 mg/ml​
H3​
Hops, whole
Humulus lupulus
IC50 >.4 < .7 mg/ml​
H8​
Horsetail​
Equisetum arvense
IC50 >.4 < .7 mg/ml​
P14​
Japenese Indigo​
Polygonum tinctorium levis
IC50 >.4 < .7 mg/ml​
K2​
Kombu​
Laminaria setchellii
IC50 >.4 < .7 mg/ml​
L6​
Lily of the valley​
Convallaria majalis
IC50 >.4 < .7 mg/ml​
L23​
Lysimachia​
Lysimachia christinae
IC50 >.4 < .7 mg/ml​
M32​
Marjoram a
Origanum majorana
IC50 >.4 < .7 mg/ml​
M31​
Melilot Herb​
Melilotus vulgaris
IC50 >.4 < .7 mg/ml​
M34​
Mint​
Mentha haplocalyx
IC50 >.4 < .7 mg/ml​
M39​
Mistle Toe​
Phoradendron flavescens
IC50 >.4 < .7 mg/ml​
M8​
Mugwort​
Artemisia vulgaris
IC50 >.4 < .7 mg/ml​
M36​
Mullein leaf​
Verbascum thapsus
IC50 >.4 < .7 mg/ml​
P12​
Papaya Leaf​
Carica papaya
IC50 >.4 < .7 mg/ml​
P5​
Peach leaf​
Prunus persica
IC50 >.4 < .7 mg/ml​
P81​
Pennyroyal​
Mentha pulegium
IC50 >.4 < .7 mg/ml​
P56​
Peony​
Paeonia suffructicose root - bark
IC50 >.4 < .7 mg/ml​
P79​
Peppermint a
Mentha piperita
IC50 >.4 < .7 mg/ml​
P88​
Periwinkle​
Vinca minor
IC50 >.4 < .7 mg/ml​
P3​
Plantain Herb​
Plantago asiatica
IC50 >.4 < .7 mg/ml​
P85​
Plantain Leaf​
Plantago major
IC50 >.4 < .7 mg/ml​
R21​
Red rose And Petals​
Rosa damascena
IC50 >.4 < .7 mg/ml​
R2​
Redroot​
Ceanothus americanus
IC50 >.4 < .7 mg/ml​
C77​
Senna Leaf​
Cassia angustifolia leaf
IC50 >.4 < .7 mg/ml​
S19​
Shepards Purse a
Capsella bursa-pastoris
IC50 >.4 < .7 mg/ml​
L7​
Spice Bush​
Lindera aggregata root
IC50 >.4 < .7 mg/ml​
S33​
Spikemoss​
Selaginella doederleinii
IC50 >.4 < .7 mg/ml​
S60​
Spiralina powder​
Arthrospira platensis
IC50 >.4 < .7 mg/ml​
S72​
Spirulina​
Arthrospira platensis
IC50 >.4 < .7 mg/ml​
C40​
Spreading sneezeweed​
Centepida mimima
IC50 >.4 < .7 mg/ml​
S3​
Strawberry Leaf​
Fragaria vesca
IC50 >.4 < .7 mg/ml​
S28​
Sweet Grass Braid​
Hierochlöe Odorata
IC50 >.4 < .7 mg/ml​
T1​
Tansy​
Tanacetum vulgare
IC50 >.4 < .7 mg/ml​
T5​
Tarragon​
Artemisia dracunculus
IC50 >.4 < .7 mg/ml​
C95​
Tea​
Celyon (black tea)
IC50 >.4 < .7 mg/ml​
T2​
Thyme Leaf a
Thymus vulgaris
IC50 >.4 < .7 mg/ml​
S68​
Toothache Plant​
Spilanthes acmella
IC50 >.4 < .7 mg/ml​
S22​
Touch me not​
Speranskia tuberculata
IC50 >.4 < .7 mg/ml​
T30​
Turkey Rhubarb​
Rheum palmatum
IC50 >.4 < .7 mg/ml​
V2​
Vervain​
Verbena officinalis herb
IC50 >.4 < .7 mg/ml​
W16​
White Willow Bark​
Salix alba
IC50 >.4 < .7 mg/ml​
P73​
Wintergreen​
Pyrola calliantha
IC50 >.4 < .7 mg/ml​
W8​
Wormwood​
Artemisia absinthum
IC50 >.4 < .7 mg/ml​
A44​
Wormwood​
Artemisia capillaris
IC50 >.4 < .7 mg/ml​
LEVEL 5
A41​
Agrimony​
Agrimonia pilosa
IC50≈.7 mg/kg​
S74​
Alexandrian Senna​
Senna alexandrina
IC50≈.7 mg/kg​
A6​
Asafoetida​
Ferula Assa-Foetida
IC50≈.7 mg/kg​
D9​
BAI CAI GAN​
Dried Chinese Cabbage
IC50≈.7 mg/kg​
B27​
Black Berry Powder​
Rubus armeniacus
IC50≈.7 mg/kg​
I7​
Black Henna​
Indigofera tinctoria
IC50≈.7 mg/kg​
C91​
Cayenne powder​
Capsicum annuum
IC50≈.7 mg/kg​
V6​
Chaste Tree Berry​
Vitex agnus-castus
IC50≈.7 mg/kg​
C12​
Chickweed​
Stellaria media
IC50≈.7 mg/kg​
P29​
Chinese Cinquefoil​
Potentilla chinensis
IC50≈.7 mg/kg​
T24​
Dandelion Root​
Taraxacum mongolicum
IC50≈.7 mg/kg​
D5​
Dill weed​
Anethum graveolens
IC50≈.7 mg/kg​
A26​
Dogbane​
Apocynum venetum herb
IC50≈.7 mg/kg​
F20​
Fennel seed a
Foeniculum vulgare
IC50≈.7 mg/kg​
F22​
Fringe Bark Tree​
Chionanthus virginicus
IC50≈.7 mg/kg​
F23​
Fumitory​
Fumaria officinalis
IC50≈.7 mg/kg​
G27​
Garcinia cambogia​
Garcinia cambogia
IC50≈.7 mg/kg​
G23​
Gardenia​
Gardenia jasminoides fruit
IC50≈.7 mg/kg​
S31​
Japanese Catnip​
Schizonepeta tenuifolia
IC50≈.7 mg/kg​
P22​
Knotweed Grass​
Polygonum aviculare
IC50≈.7 mg/kg​
M37​
Malva Flower​
Malva sylvestris
IC50≈.7 mg/kg​
N11​
Nettle stinging​
Urtica dioica
IC50≈.7 mg/kg​
O18​
Oatstraw
Avena sativa
IC50≈.7 mg/kg​
O14​
Orange peel​
Citrus sinensis
IC50≈.7 mg/kg​
O12​
Oregano leaf a
Origanum vulgare
IC50≈.7 mg/kg​
O2​
Osha Root​
Ligusticum porteri
IC50≈.7 mg/kg​
P27​
Patrinia​
Patrinia villosa herb
IC50≈.7 mg/kg​
P28​
Purslane​
Portulaca oleracea
IC50≈.7 mg/kg​
R8​
Raspberry Leaf​
Rubus idaeus
IC50≈.7 mg/kg​
H29​
Strawflower​
Helichrysum foetidum
IC50≈.7 mg/kg​
E25​
Tea​
English breakfast black tea
IC50≈.7 mg/kg​
I9​
Tea​
Irish breakfast green tea
IC50≈.7 mg/kg​
S41​
The Holy Herb​
Siegesbeckia orientalis
IC50≈.7 mg/kg​
P18​
Tongue fern​
Pyrrosia Lingua
IC50≈.7 mg/kg​
G26​
Wintergreen​
Gaultheria procumbens
IC50≈.7 mg/kg​
aBotanical Replicates confirmed from various distributors.
 

golder

Member
Joined
May 10, 2018
Messages
2,851
Interesting. Level 1 is the weakest MAOB inhibitors and level 5 is the strongest?
 

aliml

Member
Joined
Apr 17, 2017
Messages
692
Interesting. Level 1 is the weakest MAOB inhibitors and level 5 is the strongest?
"Extracts demonstrating the greatest potency are listed as Level 1 (strongest), followed by Level 2 (strong), Level 3 (moderately strong), Level 4 (moderate) and Level 5 (weak)"
 

jasieltego

Member
Joined
Sep 15, 2021
Messages
28
Location
USA
Amazing list shared with us, thank you.
This is for OP, I started taking Wild Green Oat Extract , 2 doses of 800mg twice a day.
I felt it immediately, I felt my brain become lifted, as if some pressure was lifted off.
It's been a full week now taking Wild Green Oat Extract and I still feel the benefits from it.
I feel a sharper, a bit faster processing things, most importantly It's helped me with baby induced stress lol
I have an infant and a 1 year old, and they can be very stressful. Stress reduction and Stress resilience has been a big one for me.

However, According to this chart, the oatmeal extract is level 5, weak. But it's working fine for me, for now.
However, I'm curious now and I will try Amur Cork Tree , once I'm done with my bottle of Wild green Oat extract.

Does anyone have any experiences to share of Wild Green oat extract vs Amur Cork Tree.
I also would like to try some type of nootropics, but I read that some of them do increase Dopamine but at the same time they also increase serotonin. Maybe I understood it wrong.
For now , I just stick to Wild Green Oat Extract , and soon will try Amur Cork tree.
 

TacoVampire

Member
Joined
Feb 7, 2020
Messages
51
Location
nyc
Reading this thread made me get my STRATEGENE report from a few years ago.

1648783621193.png

I have a double mutation. (thanks mom. thanks dad!)

Just to clarify. This mutation causes me to use up(metabolize) dopamine? IOW - I have a deficiency of dopamine? thanks!
 

golder

Member
Joined
May 10, 2018
Messages
2,851
Reading this thread made me get my STRATEGENE report from a few years ago.

View attachment 35211
I have a double mutation. (thanks mom. thanks dad!)

Just to clarify. This mutation causes me to use up(metabolize) dopamine? IOW - I have a deficiency of dopamine? thanks!
What's the best way to get you back to baseline?
 

atlee7757

Member
Joined
May 6, 2015
Messages
53

High throughput Screening to Identify Natural Human MAO-B Inhibitors​


Age-related increase in monoamine oxidase B (MAO-B) may contribute to CNS neurodegenerative diseases. Moreover, MAO-B inhibitors are used in the treatment of idiopathic Parkinson disease as preliminary monotherapy or adjunct therapy with L-dopa. To date, meager natural sources of MAO-B inhibitors have been identified, and the relative strength, potency and rank of many plants relative to standard drugs such as Selegiline (L-deprenyl, Eldepryl) are not known. In this work, we developed and utilized a high throughput enzyme microarray format to screen and evaluate 905 natural product extracts (0.025–.7 mg/ml) to inhibit human MAO-B derived from BTI-TN-5B1-4 cells infected with recombinant baculovirus. The protein sequence of purified enzyme was confirmed using 1D gel electrophoresis-matrix assisted laser desorption ionization-time-of-flight-tandem mass spectroscopy, and enzyme activity was confirmed by [1] substrate conversion (3-mM benzylamine) to H202 and [2] benzaldehyde. Of the 905 natural extracts tested, the lowest IC50s [<0.07 mg/ml] were obtained with extracts of Amur Corktree (Phellodendron amurense), Bakuchi Seed (Cyamopsis psoralioides), Licorice Root (Glycyrrhiza glabra/uralensis), Babchi (Psoralea corylifolia seed). The data also show, albeit to a lesser extent, inhibitory properties of herbs originating from the mint family (Lamiaceae) and Turmeric, Comfrey, Bringraj, Skullcap, Kava-kava, Wild Indigo, Gentian and Green Tea. In conclusion, the data reflect relative potency information by rank of commonly used herbs and plants that contain human MAO-B inhibitory properties in their natural form.


Natural plant sources of human MAO-B inhibitors​


LEVEL​
ID​
Common name​
Scientific name​
Inhibitory conc.​
LEVEL 1
A9​
Amur Cork Tree​
Phellodendron amurense
IC50 <.07 mg/ml​
B54​
Bakuchi Seed a
Cyamopsis psoralioides
IC50 <.07 mg/ml​
L2​
Licorice Root​
Glycyrrhiza glabra
IC50 <.07 mg/ml​
G22​
Gan Cao a
Glycyrrhiza uralensis root
IC50 <.07 mg/ml​
P58​
Psoralea Fruit Babchi a
Psoralea corylifolia
IC50 <.07 mg/ml​
LEVEL 2
P15​
Beefsteakplant a
Perilla frutescens leaf
IC50 <.2 mg/ml​
W4​
Black Pepper​
Piper nigrum
IC50 <.2 mg/ml​
B15​
Bringraj ‘False Daisy’​
Eclipta erecta
IC50 <.2 mg/ml​
C34​
Chinese arborvitae a
Truja, Platycladus orientalis twig/leaf
IC50 <.2 mg/ml​
C2​
Comfrey​
Symphytum officinale leaf
IC50 <.2 mg/ml​
C84​
Curry powder​
Coriander, turmeric, cumin, fenugreek, red pepper
IC50 <.2 mg/ml​
F4​
Figwort​
Scrophularia nodosa
IC50 <.2 mg/ml​
S54​
Gloryvine Stem​
Sargentodoxa cuneata
IC50 <.2 mg/ml​
XT3​
Green Tea​
Camellia sinensis
IC50 <.2 mg/ml​
H20​
Herb de province​
Oregano, thyme, savory, lavender, basil, sage, rosemary
IC50 <.2 mg/ml​
K8​
Kava Kava​
Piper methysticum
IC50 <.2 mg/ml​
L45​
Ladys’ Mantle​
Alchemilla vulgaris
IC50 <.2 mg/ml​
A37​
Lesser Galangal​
Alpinia officinarum Root
IC50 <.2 mg/ml​
L35​
Red Henna​
Lawsonia inermis
IC50 <.2 mg/ml​
C53​
Sappanwood​
Caesalpinia sappan wood
IC50 <.2 mg/ml​
D10​
Thick-stemmed Wooda
Dryopteris crassirhizoma
IC50 <.2 mg/ml​
T3​
Turmeric a
Curcuma Longa
IC50 <.2 mg/ml​
W13​
Watercress​
Nasturtium officinale
IC50 <.2 mg/ml​
W3​
Wild Indigo Root​
Baptisia tinctoria
IC50 <.2 mg/ml​
W10​
Wild lettuce​
Lactuca virosa
IC50 <.2 mg/ml​
G6​
Yellow Gentian Root​
Gentiana lutea
IC50 <.2 mg/ml​
LEVEL 3
A4​
Alfalfa​
Medicago sativa
IC50 >.2 <.4 mg/ml​
A48​
Alpinia​
Alpinia katsumadai seed
IC50 >.2 <.4 mg/ml​
B48​
Bay Leaf​
Laurus nobilis
IC50 >.2 <.4 mg/ml​
B13​
Bayberry Root bark a
Morella cerifera
IC50 >.2 <.4 mg/ml​
C103​
Cedar Berries​
Juniperus monosperma
IC50 >.2 <.4 mg/ml​
C101​
Celandine​
Chelidonium majus
IC50 >.2 <.4 mg/ml​
S56​
Common hedgenettle​
Stachys officinales
IC50 >.2 <.4 mg/ml​
E3​
Eucalyptus Leaf​
Eucalyptus globulus
IC50 >.2 <.4 mg/ml​
E6​
Eyebright​
Euphrasia officinalis
IC50 >.2 <.4 mg/ml​
D18​
Fringed Pink​
Dianthus superbus
IC50 >.2 <.4 mg/ml​
G31​
Garam Marsala​
Garam Marsala
IC50 >.2 <.4 mg/ml​
G28​
Gourmet pepper mill​
Gourmet pepper mill
IC50 >.2 <.4 mg/ml​
G29​
Gunpowder green tea​
Camellia sinensis
IC50 >.2 <.4 mg/ml​
H22​
Hyssop​
Hyssopus officinalis
IC50 >.2 <.4 mg/ml​
P89​
Indian long pepper​
Piper longum
IC50 >.2 <.4 mg/ml​
I2​
Isatis Leaf​
Isatis indigotica; Isatis tinctoria
IC50 >.2 <.4 mg/ml​
I8​
Italian spice herbal tea​
Italian spice herbal tea
IC50 >.2 <.4 mg/ml​
K9​
Kola Nut​
Cola acuminata
IC50 >.2 <.4 mg/ml​
L43​
Lemon Curry​
Lemon curry
IC50 >.2 <.4 mg/ml​
L49​
Lemon Verbana​
Aloysia triphylla
IC50 >.2 <.4 mg/ml​
M20​
Lilly Tree​
Magnolia denudata flower
IC50 >.2 <.4 mg/ml​
L46​
Linden Leaf​
Tilia europaea
IC50 >.2 <.4 mg/ml​
M38​
Maiden Hair Fern​
Adiantum capillus
IC50 >.2 <.4 mg/ml​
M40​
Motherwort​
Leonurus cardiaca
IC50 >.2 <.4 mg/ml​
P4​
Parsley​
Petroselinum crispum
IC50 >.2 <.4 mg/ml​
R4​
Red Clover​
Trifolium pratense
IC50 >.2 <.4 mg/ml​
R9​
Red Sandlewood​
Pterocarpus santalinus
IC50 >.2 <.4 mg/ml​
L33​
Rough bugleweed​
Lycopus lucidus
IC50 >.2 <.4 mg/ml​
S61​
Sage​
Salvia officinalis
IC50 >.2 <.4 mg/ml​
S23​
Sassafras​
Sassafras Albidum
IC50 >.2 <.4 mg/ml​
E21​
Scouringrush horsetail​
Equisetum Heimale
IC50 >.2 <.4 mg/ml​
S32​
Skull cap a
Scutellaria barbata
IC50 >.2 <.4 mg/ml​
S16​
Skull cap a
Scutellaria lateriflora
IC50 >.2 <.4 mg/ml​
S64​
Spearmint a
Mentha spicata
IC50 >.2 <.4 mg/ml​
S20​
Stevia/Candyleaf​
Stevia rebaudiana
IC50 >.2 <.4 mg/ml​
S15​
Szechuan pepper​
Zanthoxylum bungeanum
IC50 >.2 <.4 mg/ml​
W11​
White Sage​
Salvia apiana
IC50 >.2 <.4 mg/ml​
Y8​
Yohimbe Bark​
Corynanthe yohimbe
IC50 >.2 <.4 mg/ml​
Y7​
Young Hyson Green Tea​
Camellia sinensis
IC50 >.2 <.4 mg/ml​
V1​
Zi Hua Di Ding​
Viola yedoensis herb
IC50 >.2 <.4 mg/ml​
LEVEL 4
ID
Common Name
Scientific Name
Inhibitory Conc.​
A67​
Ancho chili pepers​
Capsicum annum
IC50 >.4 < .7 mg/ml​
B19​
Blackberry leaf​
Rubus fruticosus
IC50 >.4 < .7 mg/ml​
B12​
Blackberry Root​
Rubus fruticosus or Rubus Villosus
IC50 >.4 < .7 mg/ml​
F17​
Bladderwrack​
Fucus vesiculosus
IC50 >.4 < .7 mg/ml​
B26​
Blessed Thistle​
Cnicus benedictus
IC50 >.4 < .7 mg/ml​
C1​
California Poppy​
Eschscholzia californica
IC50 >.4 < .7 mg/ml​
C87​
Catnip a
Nepeta cataria
IC50 >.4 < .7 mg/ml​
H16​
Chameleon​
Houttuynia cordata herb
IC50 >.4 < .7 mg/ml​
c80​
Cilantro Leaf​
Coriandrum sativum
IC50 >.4 < .7 mg/ml​
C39​
Cinnamon Twig​
Cinnamomum cassia
IC50 >.4 < .7 mg/ml​
C9​
Cleavers​
Galium aparine
IC50 >.4 < .7 mg/ml​
A49​
Clematis trifoliata​
Akebia trifoliata fruit
IC50 >.4 < .7 mg/ml​
D1​
Damiana Leaf​
Turnera diffusa
IC50 >.4 < .7 mg/ml​
E24​
Earlgrey black tea​
Earlgrey black tea
IC50 >.4 < .7 mg/ml​
E23​
Elder berries​
Sambucus nigra
IC50 >.4 < .7 mg/ml​
E2​
Epidedium​
Epimedium grandiflorum
IC50 >.4 < .7 mg/ml​
E15​
Epidedium​
Epimedium koreanum
IC50 >.4 < .7 mg/ml​
F2​
Feverfew​
Tanacetum parthenium
IC50 >.4 < .7 mg/ml​
C17​
Garden Chervil​
Anthriscus cerefoilium
IC50 >.4 < .7 mg/ml​
G30​
German chamomile​
Matricaria recutita
IC50 >.4 < .7 mg/ml​
G37​
Goats Rue​
Galega officinalis
IC50 >.4 < .7 mg/ml​
G8​
Great Valley gumweed​
Grindelia camporum
IC50 >.4 < .7 mg/ml​
L3​
Gromwell root​
Lithospermum erythrorhizon root
IC50 >.4 < .7 mg/ml​
G4​
Gymnema​
Gymnema sylvestre
IC50 >.4 < .7 mg/ml​
H3​
Hops, whole
Humulus lupulus
IC50 >.4 < .7 mg/ml​
H8​
Horsetail​
Equisetum arvense
IC50 >.4 < .7 mg/ml​
P14​
Japenese Indigo​
Polygonum tinctorium levis
IC50 >.4 < .7 mg/ml​
K2​
Kombu​
Laminaria setchellii
IC50 >.4 < .7 mg/ml​
L6​
Lily of the valley​
Convallaria majalis
IC50 >.4 < .7 mg/ml​
L23​
Lysimachia​
Lysimachia christinae
IC50 >.4 < .7 mg/ml​
M32​
Marjoram a
Origanum majorana
IC50 >.4 < .7 mg/ml​
M31​
Melilot Herb​
Melilotus vulgaris
IC50 >.4 < .7 mg/ml​
M34​
Mint​
Mentha haplocalyx
IC50 >.4 < .7 mg/ml​
M39​
Mistle Toe​
Phoradendron flavescens
IC50 >.4 < .7 mg/ml​
M8​
Mugwort​
Artemisia vulgaris
IC50 >.4 < .7 mg/ml​
M36​
Mullein leaf​
Verbascum thapsus
IC50 >.4 < .7 mg/ml​
P12​
Papaya Leaf​
Carica papaya
IC50 >.4 < .7 mg/ml​
P5​
Peach leaf​
Prunus persica
IC50 >.4 < .7 mg/ml​
P81​
Pennyroyal​
Mentha pulegium
IC50 >.4 < .7 mg/ml​
P56​
Peony​
Paeonia suffructicose root - bark
IC50 >.4 < .7 mg/ml​
P79​
Peppermint a
Mentha piperita
IC50 >.4 < .7 mg/ml​
P88​
Periwinkle​
Vinca minor
IC50 >.4 < .7 mg/ml​
P3​
Plantain Herb​
Plantago asiatica
IC50 >.4 < .7 mg/ml​
P85​
Plantain Leaf​
Plantago major
IC50 >.4 < .7 mg/ml​
R21​
Red rose And Petals​
Rosa damascena
IC50 >.4 < .7 mg/ml​
R2​
Redroot​
Ceanothus americanus
IC50 >.4 < .7 mg/ml​
C77​
Senna Leaf​
Cassia angustifolia leaf
IC50 >.4 < .7 mg/ml​
S19​
Shepards Purse a
Capsella bursa-pastoris
IC50 >.4 < .7 mg/ml​
L7​
Spice Bush​
Lindera aggregata root
IC50 >.4 < .7 mg/ml​
S33​
Spikemoss​
Selaginella doederleinii
IC50 >.4 < .7 mg/ml​
S60​
Spiralina powder​
Arthrospira platensis
IC50 >.4 < .7 mg/ml​
S72​
Spirulina​
Arthrospira platensis
IC50 >.4 < .7 mg/ml​
C40​
Spreading sneezeweed​
Centepida mimima
IC50 >.4 < .7 mg/ml​
S3​
Strawberry Leaf​
Fragaria vesca
IC50 >.4 < .7 mg/ml​
S28​
Sweet Grass Braid​
Hierochlöe Odorata
IC50 >.4 < .7 mg/ml​
T1​
Tansy​
Tanacetum vulgare
IC50 >.4 < .7 mg/ml​
T5​
Tarragon​
Artemisia dracunculus
IC50 >.4 < .7 mg/ml​
C95​
Tea​
Celyon (black tea)
IC50 >.4 < .7 mg/ml​
T2​
Thyme Leaf a
Thymus vulgaris
IC50 >.4 < .7 mg/ml​
S68​
Toothache Plant​
Spilanthes acmella
IC50 >.4 < .7 mg/ml​
S22​
Touch me not​
Speranskia tuberculata
IC50 >.4 < .7 mg/ml​
T30​
Turkey Rhubarb​
Rheum palmatum
IC50 >.4 < .7 mg/ml​
V2​
Vervain​
Verbena officinalis herb
IC50 >.4 < .7 mg/ml​
W16​
White Willow Bark​
Salix alba
IC50 >.4 < .7 mg/ml​
P73​
Wintergreen​
Pyrola calliantha
IC50 >.4 < .7 mg/ml​
W8​
Wormwood​
Artemisia absinthum
IC50 >.4 < .7 mg/ml​
A44​
Wormwood​
Artemisia capillaris
IC50 >.4 < .7 mg/ml​
LEVEL 5
A41​
Agrimony​
Agrimonia pilosa
IC50≈.7 mg/kg​
S74​
Alexandrian Senna​
Senna alexandrina
IC50≈.7 mg/kg​
A6​
Asafoetida​
Ferula Assa-Foetida
IC50≈.7 mg/kg​
D9​
BAI CAI GAN​
Dried Chinese Cabbage
IC50≈.7 mg/kg​
B27​
Black Berry Powder​
Rubus armeniacus
IC50≈.7 mg/kg​
I7​
Black Henna​
Indigofera tinctoria
IC50≈.7 mg/kg​
C91​
Cayenne powder​
Capsicum annuum
IC50≈.7 mg/kg​
V6​
Chaste Tree Berry​
Vitex agnus-castus
IC50≈.7 mg/kg​
C12​
Chickweed​
Stellaria media
IC50≈.7 mg/kg​
P29​
Chinese Cinquefoil​
Potentilla chinensis
IC50≈.7 mg/kg​
T24​
Dandelion Root​
Taraxacum mongolicum
IC50≈.7 mg/kg​
D5​
Dill weed​
Anethum graveolens
IC50≈.7 mg/kg​
A26​
Dogbane​
Apocynum venetum herb
IC50≈.7 mg/kg​
F20​
Fennel seed a
Foeniculum vulgare
IC50≈.7 mg/kg​
F22​
Fringe Bark Tree​
Chionanthus virginicus
IC50≈.7 mg/kg​
F23​
Fumitory​
Fumaria officinalis
IC50≈.7 mg/kg​
G27​
Garcinia cambogia​
Garcinia cambogia
IC50≈.7 mg/kg​
G23​
Gardenia​
Gardenia jasminoides fruit
IC50≈.7 mg/kg​
S31​
Japanese Catnip​
Schizonepeta tenuifolia
IC50≈.7 mg/kg​
P22​
Knotweed Grass​
Polygonum aviculare
IC50≈.7 mg/kg​
M37​
Malva Flower​
Malva sylvestris
IC50≈.7 mg/kg​
N11​
Nettle stinging​
Urtica dioica
IC50≈.7 mg/kg​
O18​
Oatstraw
Avena sativa
IC50≈.7 mg/kg​
O14​
Orange peel​
Citrus sinensis
IC50≈.7 mg/kg​
O12​
Oregano leaf a
Origanum vulgare
IC50≈.7 mg/kg​
O2​
Osha Root​
Ligusticum porteri
IC50≈.7 mg/kg​
P27​
Patrinia​
Patrinia villosa herb
IC50≈.7 mg/kg​
P28​
Purslane​
Portulaca oleracea
IC50≈.7 mg/kg​
R8​
Raspberry Leaf​
Rubus idaeus
IC50≈.7 mg/kg​
H29​
Strawflower​
Helichrysum foetidum
IC50≈.7 mg/kg​
E25​
Tea​
English breakfast black tea
IC50≈.7 mg/kg​
I9​
Tea​
Irish breakfast green tea
IC50≈.7 mg/kg​
S41​
The Holy Herb​
Siegesbeckia orientalis
IC50≈.7 mg/kg​
P18​
Tongue fern​
Pyrrosia Lingua
IC50≈.7 mg/kg​
G26​
Wintergreen​
Gaultheria procumbens
IC50≈.7 mg/kg​
aBotanical Replicates confirmed from various distributors.

Almost all plant/herbals have MAO inhibiting properties ( also many have Acetylcholine Esterase Inhibiting properties).

Many people (including me) could be taking/consuming dozens of these every day.

I am very concerned that the additive effect would grossly suppress MAO enzymes and would be capable of negating the benefits of taking any one of these as an individual supplement/food.

Does anybody have thoughts or experiences with over inhibiting MAO ?
 

mostlylurking

Member
Joined
May 13, 2015
Messages
3,078
Location
Texas
I thought on taking avena sativa because of its mao b inhibition that raises dopamine but are there any mao b inhibitors like avena sativa that are stronger
You might find this article helpful:
quote:
A thiamine deficiency stresses the mitochondria and decreases ATP production. Less ATP in the brain decreases an enzyme that regulates dopamine levels and can lead to low levels of dopamine and bring feelings of tiredness, no motivation or focus, etc…


It is shown that a thiamine deficiency induces degeneration of dopamine neurons (8).


A deficiency in thiamine also increases serotonin synthesis and decreases its uptake, resulting in a stronger action of serotonin, which antagonizes dopamine further (9).


Increased intake of thiamine increases serotonin disposal and inhibits dopamine reuptake, thus resulting in a stronger action of dopamine. It is said that Steve Jobs took massive doses of thiamine when he was experimenting with LSD and said both were about equally effective as idea stimulators, but B1 did not have the “trip” effect.
-end paste-

Does anybody have thoughts or experiences with over inhibiting MAO ?

"What are Monoamine oxidase inhibitors?​

Monoamine oxidase inhibitors (also called MAO inhibitors or MAOIs) block the actions of monoamine oxidase enzymes.
Monoamine oxidase enzymes are responsible for breaking down neurotransmitters such as dopamine, norepinephrine, and serotonin in the brain. Historically, experts have associated low levels of these three neurotransmitters with depression, although this may not be the cause of depression. MAOIs increase the concentration of these three neurotransmitters by blocking the effects of monoamine oxidase enzymes."
-end paste-

While thiamine deficient and suffering from a thiamine functional blockage I was unable to tolerate any methylene blue. I also could not tolerate high serotonin foods, including bananas and pineapple. So yes, I have experienced "over inhibiting MAOs". This basically equals to very high serotonin in the brain.
 

Similar threads

Back
Top Bottom