methylenewhite
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- Aug 21, 2018
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Came across this paper mentioning subgroups of uncouplers:
THE UNCOUPLING OF OXIDATIVE PHOSPHORYLATION AS A MECHANISM OF DRUG ACTION
Study of these latter substances, the uncoupling agents, reveals further subgrouping: 1) those agents which stimulate oxygen consumption and are insensitive to magnesium ion changes (e.g., dinitrophenol) and 2) agents which do not stimulate oxygen consumption while depressing phosphorylation and whose action is reversed by magnesium ions (e.g., the tetracyclines). The significance of this difference remains to be explained.
Are tetracyclines indeed OXPHOS uncouplers?
Does anybody able to explain this magnesium ions sensitivity and how to use it?
THE UNCOUPLING OF OXIDATIVE PHOSPHORYLATION AS A MECHANISM OF DRUG ACTION
Study of these latter substances, the uncoupling agents, reveals further subgrouping: 1) those agents which stimulate oxygen consumption and are insensitive to magnesium ion changes (e.g., dinitrophenol) and 2) agents which do not stimulate oxygen consumption while depressing phosphorylation and whose action is reversed by magnesium ions (e.g., the tetracyclines). The significance of this difference remains to be explained.
Are tetracyclines indeed OXPHOS uncouplers?
Does anybody able to explain this magnesium ions sensitivity and how to use it?