Are Some Psychiatric Disorders A PH Problem? Scientific American Article

[alywest]

Are Some Psychiatric Disorders a pH Problem?

Again our good old friend lactate rears its ugly head.

Of course this idea was already addressed in the article from 2009 by Dr. Peat! (Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer)

It's interesting how Dr. Peat can state all of these ideas over and over and they're open to all to read, and yet they are so largely ignored by mainstream medicine. How many times does he need to be proven right?

 

[Amazoniac]

But lactic acid is not the cause, it appears to remedy excess hydrogens that are very reactive and dangerous to the cell..

 

[Amazoniac]

Open anesthesiology book , it is all there (this time for real)

 

[alywest]

Open anesthesiology book , it is all there (this time for real)

I'm sure that there are uses for lactate, however, an excess of it in the brain appears to be correlated with bipolar depression and schizophrenia.

 

[alywest]

But lactic acid is not the cause, it appears to remedy excess hydrogens that are very reactive and dangerous to the cell..

And I seem to have misused lactic acid for lactate.

 

[Amazoniac]

No, I mean, it appears in sickness indeed, but as a consequence of Rayzord's "reduced state".

 

[alywest]

Psychological, as well as physical, stress and overactivation of glutamate receptors can cause harmful accumulation of lactate in the brain (Uehara, et al., 2005). Rather than just being "associated with" tissue damage, lactate directly contributes to the damage, for example in the brain, causing nerve cell loss by increasing the release of excitotoxic glutamate (Xiang, et al, 2004). When a panic reaction is produced by sodium lactate, the reduction of protective neurosteroids appears to contribute to the excitatory state (Eser, et al. 2006); this would make the brain more susceptible to damage.

Lactate increases blood viscosity, mimics stress, causes inflammation, and contributes to shock. Lactated Ringer's solution contributes to the tissue damage caused by shock, when it's used to resuscitate shock victims (Deree, et al., 2007, 2008): it contributes to the inflammatory processes associated with shock, unlike the use of hypertonic saline and other solutions. Lactate contributes to diabetes, inhibiting the ability to oxidize glucose. It promotes endothelial cell migration and leakiness, with increased vascular permeability factor (VPF or vascular endothelial growth factor, VEGF) (Nagy, et al. 1985): this can lead to breakdown of the "blood-brain barrier."
http://raypeat.com/

Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer

 

[alywest]

Anyway, sorry, it looks like this study was already posted by haidut in august.

 

[Amazoniac]

Rather than just being "associated with" tissue damage, lactate directly contributes to the damage

This is something common to emergency measures in the body: it appears as a desperate attempt to re-establish balance and mitigate damage, but then it starts to contribute to the damage. Yet, it wasn't the initiating factor..

 

[Amazoniac]

Anyway, sorry, it looks like this study was already posted by haidut in august.

I know the feeling.

 

[alywest]

This is something common to emergency measures in the body: it appears as a desperate attempt to restablish balance and mitigate damage, but then it starts to contribute to the damage. Yet, it wasn't the initiating factor..

I think that a lot of things like melatonin, serotonin and estrogen all have their place in dealing with an emergency in the body, but it's the excess of them that creates issues. So the high lactate measurements in the brains of some bipolar and schizophrenic people post-mortem would reflect that sort of imbalance.