Ray Peat Interview April 18 2022 - One Radio Network

-Luke-

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Edit:
Here are Patrick's show notes:
What does Dr. Peat think of Dr. Ardis’ “Watch the Water”?

Need to account for complexity of phospholipase effects regarding venom.

Is there venom in the injections? Can test them for an enzyme.

What was COVID all about?

Lab modifications made the spike proteins especially transmissible.

Dr. Palmer’s slides of virus found in autopsied vaccinated COVID patients.

What is the evidence for an influenza virus causing flu deaths?

Endotoxin from lipopolysaccharide in the gut can cause pneumonia.

Remdesevir is a gene destroying material.

60% higher death rates in comparable German hospitals of one following WHO guidelines of intubation and Remdesevir vs. one not.

Why does aspirin help?

Why do laxatives and castor oil help? They get rid of endotoxins. Bowel inflammation is a major cause of death.

Coffee helps to balance everything.

Any problem using soft bulk-forming material? Psyllium husks can be dehydrating.

Cooked or raw vegetable effect on bowel movements? Rats fed canned vegetables thrived, but raw vegetables lead to death.

Need for protein decreases in older age.

Is it beneficial to supplement with inorganic minerals? Plants prefer certain Isotope forms. Prefer light vs. heavy water.

How to gain weight? 66 y.o. female with lingering digestive problems from COVID. Check thyroid function, body temperature, Vitamin D. Should be 50-60 per nanometer. LetsGetChecked.com for home testing. Likes TSH near zero.

Historically (50’s and 60’s) used Protein Bound Iodine (PBI) test to test thyroid. Said only 5% of population needed thyroxin. But no evidence that PBI measured thyroid function. Left a legacy of not treating hypothyroid sufficiently.

TSH activates inflammatory systems. Elevated TSH is a sign of inflammation. Dr. Peat likes TSH near zero.

Armour vs. Synthroid vs. Cynoplus vs. free-dried bovine thyroid.

Because of estrogen and its effect on the liver, women are less able to activate thyroxine (T4) to make T3.

Male feels a thumping in his head, not correlated with heart beat. Something environmental resonating through the sinus?

Would chondroitin sulfate improve heart disease?

Plaque in artery is a breakdown product of PUFAs.

How long does it take Vitamin A supplementation to clear skin issues? Estrogen accelerates formation and turnover of skin plaque. Vitamin A has anti-estrogen effect.

56 y.o. male gets a purple dot on his forearm. Probably from broken capillaries. Keep cortisol low. Avoid unexposed estrogen. Carbohydrates build cholesterol.

Options for inguinal hernia? Caused by falling DHEA, Vitamin D deficiency, and excess estrogen causing poor collagen. 5,000 Vit D/day.

Scoliosis – too little thyroid, calcium, Vitamin D.

Berberine to lower blood sugar?

Phosphorus – Can be deficient if both calcium and phosphorus are low, but usually a normal ratio indicates if you have enough phosphorus.

Rhythm of estrogen in relationship to cancer. A continual small amount of estrogen can increase cancer risk, but not if interrupted once a month.

Progesterone inactivates substances that attach to estrogen and knocks out the estrogen receptor. Can have cancer without estrogen showing up in the blood. Thyroid and progesterone deficiency can cause endometriosis and then cancer.

Listener had appendix removed at age 9 because of rupture. What are the long-term effects of no appendix?

Resources in Mexico for ordering Cynoplus. Bovine thyroid – how pure, has it been standardized? Take caution with dosage.

What causes an increased tendency to flush? Histamine release. Low thyroid.

Monitor thyroid with temperature (97.8) and heart rate first thing in the morning.

Is breakfast important? High AM cortisol is a response to low glucose. Orange juice or oats good upon awakening to restore glucose.

Is milk estrogenic? Can get milk without hormones added.

Can you reduce enlarged prostate? Thyroid and aspirin, good Vitamin D level.
 
Last edited:

Sefton10

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Ray laughing about Patrick’s comment about old people hunting buffalo ?
 
OP
-Luke-

-Luke-

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Ray is back on One Radio Network next Monday. Just in case someone wants to ask a question.
 

Mauritio

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Interesting about the old man with prostate cancer thriving on a vegan diet.
 

Dave Clark

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I post it, but it never gets asked, but what does Ray think of the mineral boron {I think I know, but would like to hear what he has to say}. And, regarding progesterone for men, he usually says none, and talks about women cycling it during their month cycle. But, in this episode, he asserts progesterone for both men and women, but doesn't elaborate what men should use. I would like to have him give a formal opinion, or protocol for using progesterone for men. If someone hear has heard him answer those questions, please post.
 
P

Peatness

Guest
Some Effects of Progesterone in Men Copyright 2021 - Ray Peat, PhD

Classifying progesterone as a “pregnancy hormone” and a “female sex hormone” has seriously limited understanding of its function in both men and women. It is a stabilizer of cellular structure and function in all organs, similarly in men and women. This stabilizing effect is especially important in the nervous system, where it is protective against stress. In both men and women, a progesterone deficiency is associated with problems including seizures and bipolar disorder, irritability/elation, aggression, and depression, as well as sex-related problems.

In the 1970s, an acquaintance told me that he had become impotent following his vasectomy. I was familiar with the progesterone deficiency produced in women by tubal ligation and by intrauterine contraceptive devices, and I had seen a study of men’s hormones following a vasectomy, in which an isolated deficiency of progesterone sometimes occurred, so he decided to try some progesterone. He later said that a single dose had corrected his erectile problem. Other young men with erectile dysfunction, from other causes, had similarly good results with small amounts of progesterone.

When a problem is quickly and permanently corrected with a small amount of progesterone it seems likely that the progesterone acted in the brain to shift the balance, maintained by endorphins, away from the stress induced inhibition of progesterone and testosterone synthesis. At the same time, though, that progesterone is lowering cortisol, it is also reducing inflammation, partly by acting as an antagonist to aldosterone. Increased aldosterone is associated with erectile dysfunction (Chang, et al., 2019; Wu, et al., 2018, 2016), and it interacts locally as a testosterone antagonist. In this, and other situations involving testosterone antagonists (estrogen, cortisol, aldosterone), progesterone can have a directly testosterone- supporting effect.

After the age of 35 or 40, many men experience a decline in their resistance to stress, corresponding to the decline in protective substances such as DHEA and progesterone. Often a small amount of progesterone, 5 or 6 mg (for example, a drop of Progest-E the size of an unpopped kernel of popcorn) can make a difference, sometimes lasting for a few days or more. Paying close attention, the effects are usually noticeable within about half an hour. At a certain level, progesterone can antagonize the effects of testosterone; in younger men, 2 or 3 drops can have that effect. That effect passes within a day of stopping the progesterone. If a younger man uses progesterone topically, for example for sunburn, a little olive oil should be applied to the skin first to make it spread easily; if it’s used on a large area, the same anti- testosterone effect is likely to be noticed.

REFERENCES


Surgery. 2019 Mar;165(3):622-628. Risk of severe erectile dysfunction in primary hyperaldosteronism: A population-based propensity score matching cohort study. Chia-Hui Chang, Shih-Chieh J Chueh, Vin-Cent Wu, Likwang Chen, Yen-Hung Lin, Ya-Hui Hu, Kwan-Dun Wu, Yao- Chou Tsai.
Asian J Androl. Jan-Feb 2018;20(1):24-29. Aldosterone induces inflammatory cytokines in penile corpus cavernosum by activating the NF-κB pathway. Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji- Meng Hu , Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding.
World J Urol. 2016 Jul;34(7):999-1007. Elevated plasma aldosterone is an independent risk factor for erectile dysfunction in men. Fei Wu, Shanhua Mao, Tianfang Yu, Haowen Jiang, Qiang Ding, Gang Xu.
Endocrine. 2018 Sep;61(3):372-382. The emerging role of aldosterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction. Fei Wu, Yun Lin, Qingyong Liu.
 

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