aguilaroja
Member
- Joined
- Jul 24, 2013
- Messages
- 850
The FDA reportedly approved Elagolix/Orilissa for endometriosis on July 24. The history of modern pharma includes hype, cashing the checks, and, as in ecology, later understanding of long term effects.
Millions of people taking €722/$844 per month of pills adds up quickly to real money. Elagolix will reportedly be at pharmacies in August.
https://www.businessinsider.com/fda-approves-abbvie-endometriosis-drug-elagolix-orilissa-2018-7
“A new treatment for a condition that can feel like tiny people skating on razor blades in your stomach and affects an estimated 200 million women just got approved”
Dr. Peat has clearly expressed for decades the influence of the pituitary over effects impaired metabolism. It is easy to predict that commerce plus limited knowledge is going to lead to more unwarranted ideas about estrogen, progesterone, and metabolism. Or to paraphrase @haidut, FUD-plus.
Aging, estrogen, and progesterone
When W. Donner Denckla demonstrated that the removal of an animal's pituitary (or, in the case of an octopus, its equivalent optic gland) radically extended the animal's life span, he proposed the existence of a death hormone in the pituitary gland. But the case of the octopus makes it clear that the catabolic, death-inducing hormone is produced by the ovary, under the influence of the optic gland's gonadotropins.
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist. - PubMed - NCBI
Women who received elagolix had higher rates of hot flushes (mostly mild or moderate), higher levels of serum lipids, and greater decreases from baseline in bone mineral density than did those who received placebo; there were no adverse endometrial findings.
https://medicalresearch.com/author-...etriosis-associated-pain-with-elagolix/34695/
“Administration results in rapid, reversible, dose-dependent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, leading to reduced ovarian production of the sex hormones, estradiol and progesterone, while on therapy.”
Millions of people taking €722/$844 per month of pills adds up quickly to real money. Elagolix will reportedly be at pharmacies in August.
https://www.businessinsider.com/fda-approves-abbvie-endometriosis-drug-elagolix-orilissa-2018-7
“A new treatment for a condition that can feel like tiny people skating on razor blades in your stomach and affects an estimated 200 million women just got approved”
Dr. Peat has clearly expressed for decades the influence of the pituitary over effects impaired metabolism. It is easy to predict that commerce plus limited knowledge is going to lead to more unwarranted ideas about estrogen, progesterone, and metabolism. Or to paraphrase @haidut, FUD-plus.
Aging, estrogen, and progesterone
When W. Donner Denckla demonstrated that the removal of an animal's pituitary (or, in the case of an octopus, its equivalent optic gland) radically extended the animal's life span, he proposed the existence of a death hormone in the pituitary gland. But the case of the octopus makes it clear that the catabolic, death-inducing hormone is produced by the ovary, under the influence of the optic gland's gonadotropins.
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist. - PubMed - NCBI
Women who received elagolix had higher rates of hot flushes (mostly mild or moderate), higher levels of serum lipids, and greater decreases from baseline in bone mineral density than did those who received placebo; there were no adverse endometrial findings.
https://medicalresearch.com/author-...etriosis-associated-pain-with-elagolix/34695/
“Administration results in rapid, reversible, dose-dependent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, leading to reduced ovarian production of the sex hormones, estradiol and progesterone, while on therapy.”