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Anyone Else Getting Increased Estrogen From T3/ASPIRIN/CYPRO/PROGESTERONE

Discussion in 'Ask For Help or Advice' started by Joeyd, Jan 31, 2018.

  1. Wagner83

    Wagner83 Member

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    I'm reading this right now In Defense of Low Fat: A Call for Some Evolution of Thought (Part 1)
    I have noticed that the fat I eat is the fat I wear, and quite possibly even estrogenic load/face bloat has to do with the intake of fat (and wheat?) . Gadsie had this thread where he mentioned eating <10% fat makes high carb (not high starch) work great for him but more doesn't . Someone (me? ) had linked to a paper in the past which suggested fat intake was related to estradiol (?) levels. Among other things, tarmander seems to be benefit from using olive oil rather than other fats, something tyw and Amazoniac had hinted at. The last two have often mentioned or discussed the rice diet.
     
  2. Bart1

    Bart1 Member

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    I’ve also been experimenting with both + pansterone. I have terrible high cortisol symptoms. I stopped with everything. I think because I’m hypothyroid I have elevated stress hormones to compensate for it. T3 tend to make you much more sensitive to the effects of adrenaline I read somewhere.

    For me the problem is now how to break this cycle? What could I try to lower my cortisol if hypothyroid ?
     
  3. Anders86

    Anders86 Member

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    I also find much less estrogen with <10% fat. Skim milk, honey, oj, collagen and coke.

    Sometimes I find my nipples somewhat puffy, but mood and energy is there and I think it might be the released fat/estrogen as I find myself much slender.

    Oj with some Sugar, Salt, Collagen, Creatine, Aspirin, Magnesium, Zinc, Energin, Caffeine and Vitamin K is a bulletproof way to start my morning.
     
  4. Anders86

    Anders86 Member

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    I love magnesium as it lowers cortisol, relaxes muscles, lift brain fog and give some GABA vibes.

    Aspirin also ofcourse..
     
  5. brix

    brix Member

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    Why would cypro cause estrogen to rise?
     
  6. OP
    Joeyd

    Joeyd Member

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    Because its anticholinergic.

    And for people like me who have a genetic predisposition for very low Choline, it's a terrible idea because Choline is essential for estrogen detoxification and reduction of fatty liver.

    For years I was using cyproheptadine without understanding it was making my fatty liver much worse by depleting Choline

    I've just started supplementing phosphatidylcholine and at last my belly is getting flat, manboobs reducing a lot, etc
     
  7. Anders86

    Anders86 Member

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    Adamantane also does this for me with its anticholinergic effects. Do you have a good source to Choline? What is your source of phosphatidylcholine?

    I find eggs a double edge sword with its fat content. I like Mitolipin but small amounts in it.

    Creatine, Magnesium and Zinc is recomended for us that are genetic predisponitioned.

    I tried CDP Choline, Alpha GPC, DMAE and Phosphatidylcholine some years ago. I got both good and bad effects, but diet and sources was far from optimal. I'm still considering buying some but I can't find a product I agree with besides Mitolipin..

    If we can controll this mutation I think we actually might be lucky. I do feel I walk on an edge, but walking on the right side makes sure for great mood, brain function and longevity.

    Undermethylation seems like the safe way to a long age, I(we) just have to make sure it is a happy life.
     
  8. Spartan300

    Spartan300 Member

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    Damn.... Cypro seems to be doing this to me too. I thought it was going to be the holy grail to improve my insomnia & libido & it's done neither.

    Sleep is no different at 1mg, libido seems worse......
     
  9. Spartan300

    Spartan300 Member

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    Any benefits of phosphatidylcholine over sunflower lecithin?
     
  10. OP
    Joeyd

    Joeyd Member

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    Most products are essentially the same thing, but there's a few products such as Essentiale Forte made here in Europe which has 95% just phosphatidylcholine content and very little fat unlike Sunflower Lecithin
     
  11. OP
    Joeyd

    Joeyd Member

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    That's really interesting Anders. Sounds like you've had similar experimentation experience to me. I'm currently using a product called Essentiale Forte which is a much more concentrated version of Phosphatydylcholine than that in sunflower lecithin. So I'm getting a lot less pufa compared to lecithin. But they annoyingly use so many dodgy excepients. It's made and sold only in Europe and Asia but I think it's available on eBay in the USA.

    So have you had genetic testing done? 23 and me? The PEMT gene is the key one for us. I'm Homozygous in almost all PEMT genes.

    The thing about eggs are that if you have the PEMT gene dysfunction you can't actually convert the Choline in them to phosphatidylcholine, so they won't help.

    I initially responded very very well to creatine but after a month I developed terrible gall bladder problems and since stopping the creatine the pain has completely gone.

    The only other big concern is TMAO from Choline supplements which has been linked to serious cardiovascular problems
     
  12. Spartan300

    Spartan300 Member

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    Hi Joey, I was just looking at the Essentiale Forte & it seems to be sourced from soy beans - any PUFA concerns?
     
  13. OP
    Joeyd

    Joeyd Member

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    Because it's a very pure form of Phosphatydylcholine its actually the best option I've got at the moment. To get an equivalent amount of PC I would have to consume 2g or so sunflower lecithin which would have way more pufa
     
  14. Anders86

    Anders86 Member

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    Yes I tok a 23andme a couple years ago and are Homozygous in most COMT, MAO-A, rs4244693(PEMT) and Heterozygous in MTHFR, VDR and the rest of PEMT. I have never heard anything of PEMT before, do you have any info available?

    Yes TMAO is a concern and Haidut does not give a clear answer if Mitolipin raises TMAO.

    One thing I didn`t mention above is that I often have a lean steak a day, with latte and collagen post-workout. I belive the steak is rich in aminos like Carnitine that helps produce more Choline. I often find myself having a bowel movement after this meal and might be a beneficial way for you with a PEMT mutation to produce some Choline. A steak is also rich in Creatine.
     
  15. OP
    Joeyd

    Joeyd Member

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    Yeah I find beef is the absolute best hangover cure, far better than any other protein. The combination of Choline and carnitine and creatine must be what does it. And alcohol reduces choline stores massively so my hangovers are pretty terrible.

    I actually set up a Facebook group called "PEMT gene polymorphism group" because I'm trying to get people to share more info and I'm learning myself. 77 members so far, but hopefully it'll get bigger.

    The strategene Facebook group and specifically dr.ben lynch has got some great videos on PEMT
     
  16. Jsaute21

    Jsaute21 Member

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    Good post.
     
  17. Tarmander

    Tarmander Member

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    Interesting...my RS7946 is TT...which would suggest not being able to convert Choline to PC? I admit, I tried eating something like 12 eggs a day once to reduce tummy fat and it did ***t all.
     
  18. Tarmander

    Tarmander Member

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    I found that Mitolipin did this to me somewhat...belly fat and manboobs. which is weird as PC should do the opposite if it was clearing liver functions correcT? Here was part of my review for Mitolipin years ago: "I had some negative reactions as well. When I first started taking it, I had diarrhea for at least a week. Not that big a deal, it went away, but it was a little annoying. After being on it for a prolonged period of time, I started to notice gyno symptoms. Nips got pointier and bigger :(. I also oddly enough thought my muscles shrunk, but that is subjective. "

    I may give PC a try on its own without the vitamin E that haidut put in the product. There are other products without the crud in Essentiale Forte:

    https://www.amazon.com/Solgar-SF933...533943910&sr=8-4&keywords=phosphatidylcholine
     
  19. schultz

    schultz Member

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    Interesting. I wonder if it has something to do with RT3?
     
  20. Rosie

    Rosie Member

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    If I take more than a drop of Progesterone, I wake up with eye bags the next day.
     

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