Anxiety, overthinking, worrying, OCD might be caused by undermethylation or LOW serotonin?

[faxmulder]

Hi guys,

I'm having the following issues:

- anxiety, overthinking, worrying about the future and pessimism that make very difficult for me to focus on the present moment and actually do stuff
- hay fever
- autoimmune inflammation on scalp (I have lichen planopilaris, which is a TH2-dominant disease)
- first grade varicocele (not painful). Last year's bloodworks (I've checked also hormones) showed that I had low vitamin D and low LH luteinizing hormone. I took new bloodworks a few days ago and I'm waiting for the results
- last but not least: sleep. I have no problems in falling asleep, but I have high REM sleep vs deep sleep, thus I'm having fragmented sleep and I'm often waking up not fully refreshed. I did a sleep study recently and I'm waiting for the results

In addition, I have mild OCD symptoms (repetitive behaviors) and perfectionism. I have high histamine so I'm starting to wonder if everything might be someway related to undermethylation. For this reason, I'm thinking about doing a trial with SAMe (or TMG), B complex and inositol. What do you think?

Another theory that I have is that, considering that I'm taking Zyrtec since many months (for controlling itching caused by lichen), maybe my levels of serotonin are now too low, causing my issues?

Thanks A LOT to everybody!!

 

[shine]

TMG raises SAMe on its own and taking SAMe without TMG can lead to high homocysteine which could be a problem. So I would try out TMG + B vitamins first.

Global DNA hypomethylation and its correlation to the betaine level in peripheral blood of patients with schizophrenia - PubMed

Accumulating evidence suggests that aberrant epigenetic regulation is involved in the pathophysiology of major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BD). We previously showed that the plasma level of betaine (N,N,N-trimethylglycine), a methyl-group donor, was...

pubmed.ncbi.nlm.nih.gov

This study comes to the conclusion that global hypomethylation/low blood levels of TMG correlate with certain kinds of mental issues (schizophrenia and bipolar disease in this case). I think the resulting high histamine is the cause.

I'd try it out and see how it goes. My personal experience is that free-form histidine makes me feel horrible whereas TMG makes me feel energetic yet calm.