Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation
This is another study along the lines of what @haidut has been posting here for the last years: mental Illnesses are a metabolic problem, start in the mitochondria and (what this study doesnt mention) almost always include serotonin.
With this study they created a low metabolism / mitochondria-dysfunction / hypothyroidism by removing the uncoupling protein UCP 2 in mice, which created :
"... an anxiety prone, cognitively impaired behavioral phenotype. Further, NMDA receptor blockade in the UCP2 KO mouse model resulted in changes in synaptic plasticity, brain oscillatory and sensory gating activities."
And this is the most important part of the study, which shows that not hope is lost concerning main stream medicin!
"We conclude that disruptions in mitochondrial function may play a critical role in pathophysiology of mental illness."
This is another study along the lines of what @haidut has been posting here for the last years: mental Illnesses are a metabolic problem, start in the mitochondria and (what this study doesnt mention) almost always include serotonin.
With this study they created a low metabolism / mitochondria-dysfunction / hypothyroidism by removing the uncoupling protein UCP 2 in mice, which created :
"... an anxiety prone, cognitively impaired behavioral phenotype. Further, NMDA receptor blockade in the UCP2 KO mouse model resulted in changes in synaptic plasticity, brain oscillatory and sensory gating activities."
And this is the most important part of the study, which shows that not hope is lost concerning main stream medicin!
"We conclude that disruptions in mitochondrial function may play a critical role in pathophysiology of mental illness."
