Anxiety Leads To Lower Social Status (and Niacinamide Fixes It)

acrylic

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"Or, in formal terms, “trait anxiety” predisposes individuals to a lower social status and lower performance in competitive social groups. In fact, researchers at the Swiss institute École Polytechnique Fédérale de Lausanne have discovered the part of the brain that links anxiety with social standing — and figured out a way to manipulate it. The neuroscientists gave anxious rats, who were also subordinate when competing with their fellow rodents, a vitamin-B3 booster that targeted this specific part of the brain. Those creatures went from eating lunch alone to becoming homecoming queens. But when the drugs wore off, so did the newfound popularity.

Carmen Sandi, a researcher on the study and the head of the lab where the research was conducted, says this is the first time anyone has linked mitochondrial function in a particular region of the brain with behavior. And the findings could soon have implications for us — she and her colleagues are starting human trials. Sandi hopes they’ll be able to help out people with their “difficulties in the social world.”


http://www.ozy.com/acumen/blame-anxiety-for-your-social-status/66639
 

RMH

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Does anyone have input on dosage? I've read everything from 500mg/2X per day to 1g+/3X per day.
 

tara

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Does anyone have input on dosage? I've read everything from 500mg/2X per day to 1g+/3X per day.
Tolerance seems to vary. Possibly in part related to glycogen storage.
I'd try 100mg 3x a day for starters, and work up as long as it seems to have good effects, back down if it gets too much. Some people get nasty headaches if they take more than they can handle. Others can take 3g a day (divided) fine.
With or after meals, not on an empty stomach, reduces risk of it causing sugar crashes.
 

haidut

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Here is the actual study. It is a very interesting read as it shows that niacinamide can help restore electron transport chain activity and it is inhibition of such activity that is responsible for the anxiety. For comparison of effectiveness, injecting CoQ10 into the rats did NOT work.
Mitochondrial function in the brain links anxiety with social subordination. - PubMed - NCBI

The niacinamide was injected directly in the brain, every 3 hours. Extrapolating to oral doses required to achieve such concentrations in the brain, this means a human oral dose of about 1.5mg/kg daily is required.
 

tara

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The niacinamide was injected directly in the brain, every 3 hours. Extrapolating to oral doses required to achieve such concentrations in the brain, this means a human oral dose of about 1.5mg/kg daily is required.
Every three hours?
 

haidut

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