Antitussive Action Of Thc


May 27, 2015
r J Pharmacol. 1976 Feb;35(2):309-13.

Antitussive activity of some naturally occurring cannabinoids in anesthetized cats.

Gordon R, Gordon RJ, Sofia D.


Experimental cough was elicited in pentobarbital-anesthetized cats by either electrical stimulation of the superior laryngeal nerve or by mechanical stimulation of the tracheal mucosa. Intravenous administration of delta9-tetrahydrocannabinol (THC) effectively reduced the amplitude of the cough response in both these models of experimentally induced cough with ED50 values (AtD50) of 1.84 and 0.78 mg/kg, respectively. This cough suppressant activity of THC was more similar to codeine-PO4 than dextromethorphan-HBr. On the other hand, both cannabinol (CBN) and cannabidiol (CBD) were devoid of antitussive activity at doses as high as 10.0 mg/kg.PMID: 1248507 [PubMed - indexed for MEDLINE]
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