Antioxidants Accelerate Lung Cancer Progression In Mice

[Thomas]

http://stm.sciencemag.org/content/6/221 ... 5.abstract

any thoughts on that one?

cheers
Thomas

 

[Thomas]

got that one from facebook:

"The antioxidants in our body have to fit together with uric acid which is naturally there, and enzymes which naturally break down free radicals. And if you put things in that don't fit, apparent antioxidants in a test tube can become a pro-oxidant in a body. Things have to fit together, so that vitamin A and vitamin E are locked together and vitamin E and vit. C locked together, Uric acid and vit.C locked together and the glucose and other sugars have to be streaming through the systems of enzymes turning into carbon dioxide. Carbon dioxide has to be flowing out of the cells properly. The whole antioxidant system is really one piece and if you try to staff in any super antioxidants like they're selling as health products, you're likely create more oxidation than you had without it. Recent publication saw that cataracts are twice as common in men over the age of 65, who took big supplements of vit. E and vit. C. Almost doubled their rate of cataracts. " - R.P.

 

[burtlancast]

Strange comment by Peat, since he himself promoted the work of the Shute brothers on high dose Vit E against heart disease.

Vitamin E prevents inflammation and oxidation. It functions as an antioxidant in many environments. Government and industry have been “hiding, destroying, or ignoring” information about vit E for a long time. Industry controls the journals and funding for research, and in the 1940s vitamin E research was having a negative effect on the synthetic estrogen industry.

In 1933 physician R. J. Shute was studying preeclampsia (a circulatory problem in pregnancy). Vitamin E had been found to improve fertility, whereas estrogen was causing problems (infertility, miscarriage, excessive blood clotting). Shute and his sons considered vitamin E to be antiestrogen and prevented clotting diseases. The Shutes started giving vitamin E to treat circulatory diseases in general – hypertension, heart disease, diabetes – all did well with large doses of vitamin E.

 

[kiran]

Although Peat does point out that the substance that used to be sold as vit E is different than the modern stuff. Whether its a beneficial substance that's missing or an extra toxin is an open question.

 

[Mittir]

This is a quote from RP article
Vitamin E: Estrogen antagonist, energy promoter, and anti-inflammatory

Anything that can be oxidized and reduced (melatonin, estrogen, tryptophan, carotene, etc.) will function as an antioxidant in some system, but in other circumstances, it can be a pro-oxidant

The people who think there is benefit in the abstract "antioxidant" function seem to be thinking in terms of something that will, like a ubiquitous fire department, put out every little fire as soon as it starts. I think it's more appropriate to think of the biological antioxidant systems as programs for controlling the arsonists before they can set the fires.

Since the requirement for vitamin E decreases as the consumption of unsaturated fats decreases, the requirement, if any, would be very small if we didn't eat significant quantities of those fats.

 

[Wilfrid]

Another quote from RP:

"Antioxidants: Vitamin E and vitamin C are known as antioxidants, because they stop the harmful free· radical chain reactions which often involve oxygen, but they do not inhibit normal oxidation processes in cells. “Chain breaker” would be a more suitable term. It is often the deficiency of oxygen which unleashes the dangerous free-radical processes. Many substances can function as antioxidants/chain breakers: thyroxine, uric acid, biliverdin, selenium, iodine, vitamin A, sodium, magnesium, and lithium, and a variety of enzymes. Saturated fats work with antioxidanrs to block the spread of free-radical chain reactions.”

One member on the forum cited Nick lane's books and articles as worth reading.
His view on the supplemental antioxidants, and how they "work" in vivo and could possibly doing more harm than good, are really interesting.

http://www.nick-lane.net/double-agent%20theory.pdf