PeskyPeater
Member
Highlights Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN
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Losartan exerts antidepressant-like effect by an angiotensin receptor type-2 (AGTR2)-dependent mechanism.
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The activation of AGTR2 in cortical cells increases the levels of tropomyosin-related kinase B (TRKB) in the cell surface.
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AGTR2 can form a heterodimer with TRKB, and putatively favor the docking of FYN kinase.
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Angiotensin receptor type-1 blockers are potentially a novel class of antidepressant drugs.