(Anti Peat?) Serotonin Depletion Causes Hypothermia

[Gadsie]

Insomnia Caused by Serotonin Depletion is Due to Hypothermia

It is known that the very effective serotonin "depletor" PCPA gives cats and rats total insomnia. The reason for this seems pretty unclear but this study gives a possible explanation:

PCPA treatment reduced brain 5-HT to less than 12% of that of controls. PCPA-treated mice housed at 20°C spent significantly more time awake than controls. However, core body temperature decreased from 36.5°C to 35.1°C. When housed at 33°C, body temperature remained normal, and total sleep duration, sleep architecture, and time in each vigilance state were the same as controls. When challenged with 4°C, PCPA-treated mice experienced a precipitous drop in body temperature, whereas control mice maintained a normal body temperature.

 

[Adrenaline]

It's true that serotonin gives you heat. In fact if you get serotonin syndrome you will get hyperthermia.

But it's not a desirable heat like Thyroid. Thyroid's heat effects comes from fast metabolism. Serotonin induced high heat is a completely different (and probably negative) thing.

 

[Frankdee20]

It's true that serotonin gives you heat. In fact if you get serotonin syndrome you will get hyperthermia.

But it's not a desirable heat like Thyroid. Thyroid's heat effects comes from fast metabolism. Serotonin induced high heat is a completely different (and probably negative) thing.

Is this why MDMA toxicity can cause hyperthermia ?