Anti-inflammatory Action Of Coffee But Not Of Caffeine Consumption

Joined
Apr 8, 2018
Messages
1,142
Location
The Netherlands
Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review. - PubMed - NCBI

Coffee consumption is associated with reduced risk of conditions that share low-grade inflammation as their physiopathological basis. We therefore summarized the effects of coffee or coffee components on serum levels of inflammatory markers. Clinical trials assessing the effect of coffee, caffeine or other coffee components on inflammatory markers were searched without restriction to publication date. Fifteen studies (8 involving coffee and 7 caffeine) were included. Increased adiponectin levels were found in four of seven trials comparing filtered coffee/caffeinated coffee with placebo or comparing its levels at baseline and after consumption of medium or dark roasted coffee, but no change was seen in caffeine trials. None of the five studies assessing the effects of coffee found changes in C-reactive protein (CPR), but one out of three trials found decreased CPR levels in response to caffeine. Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies. Caffeine increased IL-10 levels in two of three trials. These data suggest a predominant anti-inflammatory action of coffee but not of caffeine consumption. Moreover, the proinflammatory and anti-inflammatory responses to caffeine point to its complex effects on the inflammatory response.
 
OP
General Orange
Joined
Apr 8, 2018
Messages
1,142
Location
The Netherlands
I tend to agree unless the decaffeination process removes some of those beneficial components.
Decaf has not the same anti-inflammatory and anti-depressant effects in the brain as regular coffee:

Hypothesis and aims
It is hypothesized that caffeinated coffee, along with key bioactive coffee
constituents will be beneficial in behaviours and biomarkers of depression in
in vivo and in vitro models of depression and inflammation.
There were three aims of the study. The primary aim of this study was to assess
the effects of caffeinated coffee, decaffeinated coffee and caffeine on behaviours and
biomarkers associated with depression in an in vivo inflammatory model of depression.
This is due to the need to establish the differences in antidepressant-
like activities associated with the consumption of caffeine, caffeinated coffee and
decaffeinated coffee in order to investigate the compounds causing the possible activity.

https://www120.secure.griffith.edu....-bf29-24c24ceac102/1/Hall,S_2016_01Thesis.pdf
 
OP
General Orange
Joined
Apr 8, 2018
Messages
1,142
Location
The Netherlands
...
Caffeinated coffee was however shown to have more pronounced effects than that of caffeine alone.
The differences in caffeinated coffee and decaffeinated coffee then showed that ferulic
acid, one of
the key bioactive coffee constituents to be decreased in decaffeinated coffee
suggesting that it is lost through the decaffeination process. Successful development of
two in vitro surrogate cell-based models were then developed representing a microglial-
like and a neuronal-like cell. These models were then used to evaluate the effects of
coffee constituents on parameters of inflammation in microglial-like cells and
neurotoxicity in neuronal-like cells.
Coffee constituents alone appeared to produce
greater reductions in indoleamine 2,3-dioxygenase (IDO) activity...
 

Lejeboca

Member
Joined
Jun 19, 2017
Messages
1,039
More on caffeine-full (vs decaffeinated) coffee having a positive correlation with adiponectin

Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study | Nutrition & Diabetes (from an experimental study referenced by the paper in OP)

"As adiponectin is secreted from adipocytes,12 coffee may have effects on adipocytes. Indeed, one of the major substances that coffee contains among several hundred other substances, caffeine, in an experimental study led to the upregulation of peroxisome proliferator-activated receptor γ expression,26 which is an essential regulator of adipocyte differentiation and maintenance.27 As no association between decaffeinated coffee consumption and adiponectin was reported,19 caffeine contained in the coffee may have acted to increase adiponectin levels."
 

Similar threads

Back
Top Bottom