Another B3 helps treat Covid study

[LeeLemonoil]

Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts - PubMed

Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively...

pubmed.ncbi.nlm.nih.gov

Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts


Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively activated macrophages is indoleamine 2,3-dioxygenase, which converts tryptophan to kynurenine for de novo synthesis of nicotinamide. Nicotinamide can be used to replenish cellular NAD+ supplies. We hypothesize that an insufficient cellular NAD+ supply is the root cause of metabolic shifts in macrophages. We assert that manipulation of nicotinamide pathways may correct deleterious immune responses. We propose evaluation of nicotinamide (Vitamin B3) and analogues, including isoniazid, nicotinamide mononucleotide and nicotinamide riboside, as potential therapy for infectious causes of sepsis, including COVID-19.
Bedanken

 

[haidut]

Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts - PubMed

Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively...

pubmed.ncbi.nlm.nih.gov

Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts


Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively activated macrophages is indoleamine 2,3-dioxygenase, which converts tryptophan to kynurenine for de novo synthesis of nicotinamide. Nicotinamide can be used to replenish cellular NAD+ supplies. We hypothesize that an insufficient cellular NAD+ supply is the root cause of metabolic shifts in macrophages. We assert that manipulation of nicotinamide pathways may correct deleterious immune responses. We propose evaluation of nicotinamide (Vitamin B3) and analogues, including isoniazid, nicotinamide mononucleotide and nicotinamide riboside, as potential therapy for infectious causes of sepsis, including COVID-19.
Bedanken

Great find. Btw, not just for COVID-19 as sepsis is the leading causes of death of people in the hospital, with or without infections (e.g. endotoxin/LPS overload can also cause sepsis). And in cases with infections, it would help for not just viral but all other kinds that could cause sepsis - bacterial, fungal, worm, etc.

 

[LeeLemonoil]

Great find. Btw, not just for COVID-19 as sepsis is the leading causes of death of people in the hospital, with or without infections (e.g. endotoxin/LPS overload can also cause sepsis). And in cases with infections, it would help for not just viral but all other kinds that could cause sepsis - bacterial, fungal, worm, etc.

Yep. On Sepsis and Covid: there is a medicine now in phase 3 trials I think that seeks approval as covid and Sepsis treatment. Name is „Rejuveinix“ - and it’s just („proprietary of course) mixture of Vit C and B1, 2, 3, 5, 6 and 12

 

[Mellow]

Sorry to bump an old thread, but saw this Substack, and a real interesting interaction of Kynurenine and NAD as a consequence of covid infection / vaccination.

Was curious people’s thoughts? The author suggests a high-carb diet could cause further issues due to producing the same “toxic metabolites’.

Kynurenine Pathway and SARS-CoV-2

"And one pathway to bind them."

hiddencomplexity.substack.com