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Androsterone May Be The Main Source Of DHT, Drives Fetal Masculinization

Discussion in 'Scientific Studies' started by haidut, Feb 27, 2019.

  1. Kunstruct

    Kunstruct Member

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    For me there is no lower flaccid lenght increase at all from either 2.5mg Pansterone per day or from 5mg Pansterone per day while applied on the scrotum after 5days. Flaccid lenght is a short as it can be, so I do have to compare anything too much. Nor there is any erection or libido gains whatsoever.
     
  2. OP
    haidut

    haidut Member

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    OK, I was just saying that other people reported it.
    Pansterone Or Pure Dhea Success Stories
    Androsterone - Liquid Androsterone For Lab/R&D

    There are more testimonials in the Pansterone thread if you have time to scroll through it. If you experience nothing then I would do blood tests for LH/FSH, androgens, prolactin, cortisol, and vitamin D. If there is primary hypogonadism then I don't know how much pregnenolone/dhea/androsterone would help.
     
  3. Lucenzo01

    Lucenzo01 Member

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    Supplementing B vitamins is neccesary for me when doing Androsterone. 5 drops of energin is enough and the difference is day and night.
     
  4. Kunstruct

    Kunstruct Member

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    Yep I will be doing some new tests , I would assume what I will be doing now in 2019 would be worse than those below since things are not better in anyway since last time.
    Here are my September 2018 results.

    DHEA-S 429 ug/dl
    Cortisol 19,17 µg/dL (usually high results at 8 AM for me other times too)
    FSH 5,79 UI/L
    LH 2,67 UI/L
    Progesterone 1,20 ng/mL
    Prolactine 13,00 ng/mL (higher than my regular 6-8 ng/ml along the years)
    TSH 1,4340 mUI/L
    Estardiol 25 (all over the place usually, from 100 to none detectable, that day I had no mammary pains, which is very rare for me)
    DHT 667 ng/dl (lower than years before)
    SHBG 27,40 nmol/L
    Free Testosterone 9 pg/mL (steadily going down thru the last years)
    Total Testosterone 684 ng/dl
     
  5. Alex Jaramillo

    Alex Jaramillo Member

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    How do they help? Does it make the andro more potent?
     
  6. Lucenzo01

    Lucenzo01 Member

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    I feel that with energin it just works. Without Energin I get the typical side effects (no libido, lower mood) with no benefits. With energin I feel the atributed benefits of androsterone without the side effects. Day and night like I said
     
  7. Alex Jaramillo

    Alex Jaramillo Member

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    What part of the rats body do you apply the energin to?
     
  8. Lucenzo01

    Lucenzo01 Member

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    Belly
     
  9. OP
    haidut

    haidut Member

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    Potentially yes. Also, NAD (niacinamide as a precursor) is a required cofactor for 3a-HSD which is one of the enzymes converting androsterone back into DHT.
    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    So, @Lucenzo01 - it is probably not a coincidence you see benefits from combining Energin with androsterone.
     
  10. Kunstruct

    Kunstruct Member

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    Haidut what do you think of those results? As I was saying the estradiol is very low that day, usually is much higher and goes hand in had with mammary gland pains of mine.
     
  11. OP
    haidut

    haidut Member

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    Cortisol is high, as you said, and that alone can explain may of the issues you describe. Probably related to stress and/or low thyroid.
     
  12. Cameron

    Cameron Member

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    Does coconut oil hydrogenated lower dht or androsterone ?
     
  13. Jing

    Jing Member

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    Anyone get any gains?
     
  14. LeeLemonoil

    LeeLemonoil Member

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    The "backdoor pathway" of androgen synthesis in human male sexual development. - PubMed - NCBI

    The "backdoor pathway" of androgen synthesis in human male sexual development.

    Abstract
    Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas male genital development required testicular testosterone plus dihydrotestosterone (DHT) made in genital skin according to a "classic" pathway. Recent work added the description of an alternative "backdoor" pathway of androgen synthesis discovered in marsupials. Unique "backdoor steroids" are found in human hyperandrogenic disorders, and genetic disruption of the pathway causes disordered male sexual development, suggesting it plays an essential role. O'Shaughnessy and colleagues now show that the principal human backdoor androgen is androsterone and provide strong evidence that it derives from placental progesterone that is metabolized to androsterone in nontesticular tissues. These studies are essential to understanding human sexual development and its disorders.
     
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