Androgens Increases SERT, Estrogens Decreases It

LCohen

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SERT aka serotonin reuptake transporter reduces serotonin levels. This study show that testosterone increases SERT levels whiles estradiol & anti-androgen decreases it.

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People. - PubMed - NCBI

...SERT binding increases correlated with treatment-induced increases in testosterone levels, suggesting that testosterone increases SERT expression on the cell surface. Conversely, 4 months of antiandrogen and estrogen treatment in male-to-female transsexuals led to decreases in SERT binding in insula, anterior, and mid-cingulate cortex...
 

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