Amantadine & Memantine

[barbwirehouse]

https://en.wikipedia.org/wiki/Memantine

Thoughts on this substance?

Memantine acts as a non-competitive antagonist at the 5-HT3 receptor, with a potency similar to that for the NMDA receptor. The clinical significance of this serotonergic activity in the treatment of Alzheimer's disease is unknown.

 

[dinkleberg]

bump on this

i have been looking into NMDA antagonists (found great success from ketamine and MXE) and this one is supposed to be the most therapeutic and least recreational of the bunch. magnesium is also an NMDA antagonist but in a different way I believe, and only has this effect if you are deficient.

 

[dookie]

Is there any big difference between Amantadine and Memantine? I know Peat mentions both these substances in interview.

I've tried 100 mg of the Amantadine, and it felt a bit like cyproheptadine, probably because it's anti-cholinergic.

Anyone else tried amantadine/Memantine?

 

[ddjd]

bump, is memantine safe to take?

 

[Evgenius]

It is almost the same like haidut's Diamant - Diamant - Liquid Adamantane For R&D

 

[Steene]

There is no significant difference between both. The adamantane derivates are modified in order to patent them and make more money with it. Just try adamantane from IdeaLabs if you want to know how the effect is.

 

[ddjd]

@Steene @Evgenius @dookie @barbwirehouse @Vinero

Memantine HCl - Solution, 20mg/mL @ 30mL

anyone bought Memantine from here?

 

[ddjd]

@dookie @Evgenius amantadine isnt the same as adamantane is it?

 

[golder]

@dookie @Evgenius amantadine isnt the same as adamantane is it?

What’s the difference anyone?

 

[rzero]

Amantadine (brand names Gocovri, Symadine, and Symmetrel[6][9]) is the organic compound 1-adamantylamine or 1-aminoadamantane, which consists of an adamantane backbone with an amino group substituted at one of the four methyne positions.

Haidut said it is claimed Amantadine is better absorbed than adamantane, but when he reached out to people asking for the evidence of this, no one would respond.

 

[johnwester130]

memantine feels like cannabis - strong empathy, slight drunkeness, makes you reflect on life. Makes you change certain behaviours.

It's my favourite drug - I used to order it from Russia. I will have to change supplier.

 

[golder]

memantine feels like cannabis - strong empathy, slight drunkeness, makes you reflect on life. Makes you change certain behaviours.

It's my favourite drug - I used to order it from Russia. I will have to change supplier.

Nice, do you have a different reaction to adamantane?
What dosage memantine do you feel those cannabis like effects?

 

[johnwester130]

Nice, do you have a different reaction to adamantane?
What dosage memantine do you feel those cannabis like effects?

Diamant - which is think is adamantane, felt very mild. Like a mild drunkenness. But noticeable. But not powerful. It doesn't feel like a drug.

Memantine kicks in massively at 20mg. It's powerful.

Reddit - Dive into anything

www.reddit.com

 

[wildworld1992]

Is there any big difference between Amantadine and Memantine? I know Peat mentions both these substances in interview.

I've tried 100 mg of the Amantadine, and it felt a bit like cyproheptadine, probably because it's anti-cholinergic.

Anyone else tried amantadine/Memantine?

Memantine is an uncompetitive and low‐affinity NMDA receptor antagonist with voltage‐dependent binding (Bormann, 1989). Unlike amantadine, memantine has no dopaminergic or anticholinergic actions.

Memantine is used for treating Alzheimer's disease

Amantadine is used for treating Parkinsons disease

 

[HustlinHussar]

memantine feels like cannabis - strong empathy, slight drunkeness, makes you reflect on life. Makes you change certain behaviours.

It's my favourite drug - I used to order it from Russia. I will have to change supplier.

So is your use predominantly recreational?

 

[johnwester130]

So is your use predominantly recreational?

I never tried a low dose.

I assume all doses change you

I suppose I only take it for recreation