Alzheimer’s Disease Nasal Vaccine To Be Tested At Brigham And Women’s Hospital

[Mito]

Alzheimer’s Disease Nasal Vaccine To Be Tested At Brigham And Women’s Hospital

Brigham and Women’s Hospital is going to test a nasal vaccine for Alzheimer’s Disease. WBZ-TV's Zinnia Maldonado reports.

news.yahoo.com

 

[aliml]

Endotoxin (LPS) May Be A Causative Factor In Alzheimer Disease (AD)

I posted recently about a study that found many of the chronic degenerative diseases can be traced back to endotoxin and excess iron. Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases This study went a step further and identified endotoxin (LPS) in the brains of AD...

raypeatforum.com

The vaccine uses the immune modulator Protollin, an investigational intranasal agent that stimulates the immune system. Protollin is made up of proteins derived from bacteria and has been used safely in humans. It is designed to activate white blood cells found in the lymph nodes on the sides and back of the neck to migrate to the brain and trigger clearance of beta-amyloid plaques, which the hospital noted is one of the hallmarks of Alzheimer’s disease.

Protollin is a novel adjuvant comprising Proteosomes non-covalently complexed with LPS.

Protollin: a novel adjuvant for intranasal vaccines - PubMed

Protollin is a novel adjuvant comprising Proteosomes non-covalently complexed with LPS. Intranasal immunization of mice with Protollin combined with detergent-split influenza antigens (HA) or recombinant influenza hemagglutinin (rHA) enhanced serum IgG and mucosal IgA levels by up to 250-fold...

pubmed.ncbi.nlm.nih.gov

Protollin is a mucosal adjuvant composed of TLR2 and TLR4 agonists.

The TLR4-TRIF pathway can protect against the development of experimental allergic asthma - PubMed

The Toll-like receptor (TLR) adaptor proteins myeloid differentiating factor 88 (MyD88) and Toll, interleukin-1 receptor and resistance protein (TIR) domain-containing adaptor inducing interferon-β (TRIF) comprise the two principal limbs of the TLR signalling network. We studied the role of...

pubmed.ncbi.nlm.nih.gov