Yesterday i noticed dark grey residue on a pan again after scouring with a metal pad & cleaning it with some kitchen tissue.
This stuff is likely Aluminium , which is damaging in the gut >10mg, & brain.
cooking.stackexchange.com
either the metal scouring wire i've been using or the pan itself is aluminium
Effects of Aluminum on the Integrity of the Intestinal Epithelium: An in Vitro and in Vivo Study
5mg/kg+ aka ~25mg+ human dose of aluminium orally, over 13 weeks, increases colon oxidative stress markers a lot, shortens colon length, induces inflammation, damages barrier function. and the higher doses induced ulcerative colitis.
They used 5mg/kg in mice to represent levels set as tolerable for humans
25mg for humans is higher than typical estimated intakes ~10mg daily. so many people probably don't have to be concerned about it to this extent.
but that can vary. e.g i'm pretty sure that grey residue i've been eating for a while counts as a decent amount of mgs. some medications antacids can be in the 100s of mgs
lower doses in another study 1.5mg/kg around 8mg human dose in mice (less than estimated standard human intakes when going by average food & water),
didn't induce colon damage alone but made colon damage after DSS worse
in rats 1.5mg/kg (~15mg) https://core.ac.uk/download/pdf/161803617.pdf causes hypersensitivity & gut pain in rodents
[but i guess dosing all at once instead of spread over a day might make a difference in these studies?]
A U.S. food additives survey calculated that most Americans ingest from 0.01 to 1.4 mg$kg body weight$d of aluminum. In the same study, it was estimated that about 5% of Americans ingested more than 95 mg/d aluminum (meaning 1.58 mg$kg$d if a 60-kg person is considered).20
In the present study, we showed that a 1.5 mg$kg$d ingestion of aluminum induced dose-dependent and persistent colorectal hypersensitivity in rodents. To link aluminum and IBS condition, we highlighted that aluminum triggered mechanisms involved in IBS pathophysiology. Indeed, we demonstrated that aluminum induced mast cell degranulation and activation of the proteinase-activated receptor-2 (PAR2) which were required for aluminum-induced visceral pain. Our findings indicate that oral exposure to aluminum can reproduce clinical and molecular features of IBS. We revealed a role for aluminum as a dietary factor that can promote abdominal hypersensitivity and a possible therapeutic strategy via controlled aluminum uptake or chelation.
Aluminium is absorbed mostly in the distal lower part of the small intestine.
some antacids & medications are very high in aluminium ( i wonder if this applies to pepcid/famotidine too)
food sources, chocolate and confectionery can be especially high Aluminium content of selected foods and food products - Environmental Sciences Europe
Ray peat mentioned steel frying pans that aren't magnetic (fridge magnet test) are high in nickel , which he said is worse than aluminium and excess iron
"There are two main types of stainless steel, magnetic and nonmagnetic. The nonmagnetic form has a very high nickel content, and nickel is allergenic and carcinogenic. It is much more toxic than iron or aluminum. You can use a little "refrigerator magnet" to test your pans. The magnet will stick firmly to the safer type of pan."
(nickel is magnetic so this is strange but looks to be a thing How Can You Tell if Stainless Steel is Good Quality? (Try this test!) – Wilmax Porcelain by this basically all of them are nickel containing only magnetic on the bottom side)
what protects against aluminium/nickel in the gut?
hesperidin from orange juice protects in the brain. thiamine chelates existing body aluminium.
might switch to an iron pan, glass ones don't seem good for flame heating. comes with problems in high amounts but should be better than aluminium or nickel. im typically on the low side for iron anyway and cooking in iron pans gives an extra 1mg - 5mg per meal. https://a99d9b858c7df59c454c-96c6ba...e.ssl.cf1.rackcdn.com/images/iron-figure2.jpg
This stuff is likely Aluminium , which is damaging in the gut >10mg, & brain.
Something dark gray coming off of sheet pan after scouring
I've been using a stainless steel sheet pan and an aluminum sheet pan for baking/roasting for the last year (new to cooking). I used the steel one regularly, so it accumulated a lot of brown stains.
either the metal scouring wire i've been using or the pan itself is aluminium
Effects of Aluminum on the Integrity of the Intestinal Epithelium: An in Vitro and in Vivo Study
5mg/kg+ aka ~25mg+ human dose of aluminium orally, over 13 weeks, increases colon oxidative stress markers a lot, shortens colon length, induces inflammation, damages barrier function. and the higher doses induced ulcerative colitis.
They used 5mg/kg in mice to represent levels set as tolerable for humans
25mg for humans is higher than typical estimated intakes ~10mg daily. so many people probably don't have to be concerned about it to this extent.
but that can vary. e.g i'm pretty sure that grey residue i've been eating for a while counts as a decent amount of mgs. some medications antacids can be in the 100s of mgs
lower doses in another study 1.5mg/kg around 8mg human dose in mice (less than estimated standard human intakes when going by average food & water),
didn't induce colon damage alone but made colon damage after DSS worse
in rats 1.5mg/kg (~15mg) https://core.ac.uk/download/pdf/161803617.pdf causes hypersensitivity & gut pain in rodents
[but i guess dosing all at once instead of spread over a day might make a difference in these studies?]
A U.S. food additives survey calculated that most Americans ingest from 0.01 to 1.4 mg$kg body weight$d of aluminum. In the same study, it was estimated that about 5% of Americans ingested more than 95 mg/d aluminum (meaning 1.58 mg$kg$d if a 60-kg person is considered).20
In the present study, we showed that a 1.5 mg$kg$d ingestion of aluminum induced dose-dependent and persistent colorectal hypersensitivity in rodents. To link aluminum and IBS condition, we highlighted that aluminum triggered mechanisms involved in IBS pathophysiology. Indeed, we demonstrated that aluminum induced mast cell degranulation and activation of the proteinase-activated receptor-2 (PAR2) which were required for aluminum-induced visceral pain. Our findings indicate that oral exposure to aluminum can reproduce clinical and molecular features of IBS. We revealed a role for aluminum as a dietary factor that can promote abdominal hypersensitivity and a possible therapeutic strategy via controlled aluminum uptake or chelation.
Aluminium is absorbed mostly in the distal lower part of the small intestine.
some antacids & medications are very high in aluminium ( i wonder if this applies to pepcid/famotidine too)
food sources, chocolate and confectionery can be especially high Aluminium content of selected foods and food products - Environmental Sciences Europe
Ray peat mentioned steel frying pans that aren't magnetic (fridge magnet test) are high in nickel , which he said is worse than aluminium and excess iron
"There are two main types of stainless steel, magnetic and nonmagnetic. The nonmagnetic form has a very high nickel content, and nickel is allergenic and carcinogenic. It is much more toxic than iron or aluminum. You can use a little "refrigerator magnet" to test your pans. The magnet will stick firmly to the safer type of pan."
(nickel is magnetic so this is strange but looks to be a thing How Can You Tell if Stainless Steel is Good Quality? (Try this test!) – Wilmax Porcelain by this basically all of them are nickel containing only magnetic on the bottom side)
what protects against aluminium/nickel in the gut?
hesperidin from orange juice protects in the brain. thiamine chelates existing body aluminium.
might switch to an iron pan, glass ones don't seem good for flame heating. comes with problems in high amounts but should be better than aluminium or nickel. im typically on the low side for iron anyway and cooking in iron pans gives an extra 1mg - 5mg per meal. https://a99d9b858c7df59c454c-96c6ba...e.ssl.cf1.rackcdn.com/images/iron-figure2.jpg
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