Alcohol Depletes A Neurotransmitter?

Waynish

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Oct 11, 2016
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It seems that in some people alcohol very quickly is able to deplete a neurotransmitter - judging by mood & energy after a few nights in a row drinking (even small amounts of alcohol). I believe this is what is often meant by, "I can't drink like I used to."

Any ideas about the mechanism or why it would deplete the mood quicker than recovery in many people?
 

Frankdee20

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Jul 13, 2017
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It seems that in some people alcohol very quickly is able to deplete a neurotransmitter - judging by mood & energy after a few nights in a row drinking (even small amounts of alcohol). I believe this is what is often meant by, "I can't drink like I used to."

Any ideas about the mechanism or why it would deplete the mood quicker than recovery in many people?

Well, how much are we talking about ? There’s interaction with DA, GABA/Glutamate and NMDA. Those are the primary targets for alcohol, and of course 5ht3
 

lampofred

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Feb 13, 2016
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It depletes a lot of things... good metabolism means you can recover quickly. Poor metabolism means you're stuck with excessive serotonin the morning after. Thus the hangover.
 

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