Aging is an energy deficiency problem, taking cardiolipin may reverse it

haidut

Member
Joined
Mar 18, 2013
Messages
18,027
Location
USA / Europe
Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a mitochondrial dysfunction problem. Conversely, reversing that energy/mitochondrial deficiency may reverse the aging/sickness. The study below corroborates the latter hypothesis, by demonstrating that aging is characterized a decline in the communication between mitochondria and the lysosomes, driven by decline in cardiolipin inside the mitochondria. As discussed before, cardiolipin is a crucial mitochondrial protein responsible for the function of the last enzyme of OXPHOS, known as cytochrome C oxidase. Multiple studies across many animal species have already demonstrated that cardiolipin content not only declines with aging but also changes in composition so that its lipid component shifts in composition from saturated fat to PUFA, and that feeding fully saturated fats to aging organisms restores their mitochondrial function back to normal. Well, in this case, the study used direct supplementation with (saturated) cardiolipin, but the effects were the same - reversal of aging and significant extension of (maximum) lifespan.

NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin - Nature Metabolism
Subcellular chatter regulates longevity

"...From their research, the scientists found a nuclear protein called NFYB-1 that switches on and off genes affecting mitochondrial activity, and which itself goes down during ageing. In mutant worms lacking this protein, mitochondria don’t work as well and worms don’t live as long. Unexpectedly, the scientists discovered that NFYB-1 steers the activity of mitochondria through another part of the cell called the lysosome, a place where basic molecules are broken down and recycled as nutrients. “We think the lysosome talks with the mitochondria through special fats called cardiolipins and ceramides, which are essential to mitochondrial activity,” says Max Planck Director, Adam Antebi, whose laboratory spearheaded the study. Remarkably, simply feeding the NFYB-1 mutant worms cardiolipin restored mitochondrial function and worm health in these strains. Because cardiolipins and ceramides are also essential for human mitochondria, this may mean human health and ageing can be improved by understanding on how such molecules facilitate communication between different parts of the cell. This work has been recently published in Nature Metabolism."
 

Jon2547

Member
Joined
Mar 2, 2021
Messages
526
Where to get Cardiolipin?
 

rei

Member
Joined
Aug 6, 2017
Messages
1,607
it's astonishing these kinds of studies even get published. Maybe we have a change in ages at hands.
 

Risingfire

Member
Joined
May 10, 2016
Messages
570
I'm going to finish my bottle of Mitolipin tonight and expect to look 5 years younger tomorrow morning!
 

Xref

Member
Joined
Apr 9, 2020
Messages
18
"Multi-omics analysis reveals that NFYB-1 is a potent repressor of lysosomal prosaposin, a regulator of glycosphingolipid metabolism. Limiting prosaposin expression unexpectedly restores cardiolipin production, mitochondrial function and longevity in the nfyb-1 background."
 

whollygod

New Member
Joined
Mar 21, 2018
Messages
4

Could someone interpret this for the below average lay person with a curious mind nonetheless?

Abstract​

Mitochondria can depolarize and trigger cell death through the opening of the mitochondrial permeability transition pore (MPTP). We recently showed that an increase in the long chain n3 polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA; 22:6n3) and depletion of the n6 PUFA arachidonic acid (ARA; 20:4n6) in mitochondrial membranes is associated with a greater Ca2+ load required to induce MPTP opening. Here we manipulated mitochondrial phospholipid composition by supplementing the diet with DHA, ARA or combined DHA+ARA in rats for 10 weeks. There were no effects on cardiac function, or respiration of isolated mitochondria. Analysis of mitochondrial phospholipids showed DHA supplementation increased DHA and displaced ARA in mitochondrial membranes, while supplementation with ARA or DHA+ARA increased ARA and depleted linoleic acid (18:2n6). Phospholipid analysis revealed a similar pattern, particularly in cardiolipin. Tetralinoleoyl cardiolipin was depleted by 80% with ARA or DHA+ARA supplementation, with linoleic acid side chains replaced by ARA. Both the DHA and ARA groups had delayed Ca2+-induced MPTP opening, but the DHA+ARA group was similar to the control diet. In conclusion, alterations in mitochondria membrane phospholipid fatty acid composition caused by dietary DHA or ARA was associated with a greater cumulative Ca2+ load required to induced MPTP opening. Further, high levels of tetralinoleoyl cardiolipin were not essential for normal mitochondrial function if replaced with very-long chain n3 or n6 PUFAs.
 

Blaze

Member
Joined
Apr 25, 2020
Messages
379
Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a mitochondrial dysfunction problem. Conversely, reversing that energy/mitochondrial deficiency may reverse the aging/sickness. The study below corroborates the latter hypothesis, by demonstrating that aging is characterized a decline in the communication between mitochondria and the lysosomes, driven by decline in cardiolipin inside the mitochondria. As discussed before, cardiolipin is a crucial mitochondrial protein responsible for the function of the last enzyme of OXPHOS, known as cytochrome C oxidase. Multiple studies across many animal species have already demonstrated that cardiolipin content not only declines with aging but also changes in composition so that its lipid component shifts in composition from saturated fat to PUFA, and that feeding fully saturated fats to aging organisms restores their mitochondrial function back to normal. Well, in this case, the study used direct supplementation with (saturated) cardiolipin, but the effects were the same - reversal of aging and significant extension of (maximum) lifespan.

NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin - Nature Metabolism
Subcellular chatter regulates longevity

"...From their research, the scientists found a nuclear protein called NFYB-1 that switches on and off genes affecting mitochondrial activity, and which itself goes down during ageing. In mutant worms lacking this protein, mitochondria don’t work as well and worms don’t live as long. Unexpectedly, the scientists discovered that NFYB-1 steers the activity of mitochondria through another part of the cell called the lysosome, a place where basic molecules are broken down and recycled as nutrients. “We think the lysosome talks with the mitochondria through special fats called cardiolipins and ceramides, which are essential to mitochondrial activity,” says Max Planck Director, Adam Antebi, whose laboratory spearheaded the study. Remarkably, simply feeding the NFYB-1 mutant worms cardiolipin restored mitochondrial function and worm health in these strains. Because cardiolipins and ceramides are also essential for human mitochondria, this may mean human health and ageing can be improved by understanding on how such molecules facilitate communication between different parts of the cell. This work has been recently published in Nature Metabolism."
The research I have read on oral supplementation treatment for membrane lipid replacement is intriguing. The consensus is that it seems to require a combo of glycerolphospholipids and fructooligosaccharides to work at all properly and make it through the digestive process. Any suggestions for a commercially available product that you think would be beneficial? Do you have anything like that in your boutique supplement store lineup?
 
Last edited:

Mauritio

Member
Joined
Feb 26, 2018
Messages
3,103
Similar threads
Thread starter Title Forum Replies Date
Lejeboca Ray Peat Interview Feb 2021 - Roddy, Dinkov, Peat - #51: Heat Shock Proteins | Antibiotic Resistance | DHT Safety | Energy and Aging Video Interviews 5
S.Seneff The Energy Maintenance Theory Of Aging: Maintaining Energy Metabolism To Allow Longevity Scientific Studies 1
haidut Mitochondria (energy) As The Main Driver Of Health, Intelligence, And Aging Scientific Studies 17
loess KMUD: Aging and Energy Reversal (2013) Audio Interview Transcripts 1
charlie KMUD: Aging and Energy Reversal 12-20-13 KMUD Radio-The Herb Doctors 5
charlie Hot Flashes, Energy, And Aging Articles & Newsletters 1
charlie March Newsletter: Hormones, Energy, Aging, and Endogenous... Articles & Newsletters Discussion 6
Drareg US Military Anti Aging Pill Society 3
GorillaHead Intercellular Zinc Deficiency a primary accelerator of aging! Male Issues 11
belcanto Estrogen, iron, degenerative aging, and progesterone - and Lactoferrin! Articles & Newsletters Discussion 20
M Would sleeping underneath a blanket/pillow replicate some benefits of bag breathing and high altitude living? does oxygen cause aging/degeneration? Ask For Help or Advice 7
G The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise Scientific Studies 1
F Homemade face moisturizer/anti aging serum ingredients advice? Ask For Help or Advice 35
Mito The Aging GABAergic System and Its Nutritional Support Scientific Studies 13
A Aging seems to progress in discrete steps - at 34, 60, 78 years Scientific Studies 5
Rinse & rePeat Aging Fast & Alien Confusion Diet 142
youngsinatra Rate My Anti-Aging Stack Supplements, Pharmaceutical Drugs 77
A Iron metabolism in aging Scientific Studies 1
Mito Carnosine improves aging-induced cognitive impairment Articles & Scientific Studies 0
A Aging - programmed or not Ray Peat Topics 28
haidut Blocking PUFA/prostaglandins restores metabolism and reverses brain aging Scientific Studies 5
cupofcoffee Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging Coffee 16
A Anti-aging, more collagen production, youthful appearance due to glitch re: histamine? Miscellaneous Health Discussions 5
Mito Early decline of androgen levels in healthy adult men: an effect of aging per se? Scientific Studies 1
egoy Reverse aging Ask For Help or Advice 49
L Aspirin As A Suppressor Of Cancer-related Epigenetic Aging Scientific Studies 2
haidut The Cure For Aging Might Be The Cure For Alzheimer’s Scientific Studies 3
haidut Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho Scientific Studies 43
haidut Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho Scientific Studies 1
haidut Childhood Stress / Deprivation Leads To Early Puberty / Aging Scientific Studies 5
haidut Topical DHEA Has Potent Anti-aging Effects On Human Skin Scientific Studies 8
haidut Simply Diluting "old Blood" Has The Same Anti-aging Effects As Parabiosis Scientific Studies 43
RWilly 100% Oxygen Therapy To Reverse Aging? Miscellaneous Health Discussions 2
Lejeboca ORN 2020-06-15: Dr. Peat On COVID Testing, Exosomes, EMFs, Gray Hair, Vaccines, Aging Audio Interview Transcripts 3
haidut Cardiolipin Supplementation May Reverse Signs Of Aging Scientific Studies 1
haidut Aspirin Protects Mitochondria From Inflammation And Aging Scientific Studies 8
haidut "Anti-aging" Hormone (hGH) May Actually Shorten Life Scientific Studies 4
S Am I Reading Ray Peat Correctly, Collagen Buildup Causes Aging Sking? Skin 8
md_a Lungs, Shock, Inflammation, And Aging Articles & Newsletters 3
md_a Angiotensin II Revisited: New Roles In Inflammation, Immunology And Aging Scientific Studies 8
md_a The Dilemma Of Coronavirus Disease 2019, Aging, And Cardiovascular Disease Scientific Studies 4
Hans Inhibiting Lipolysis Can Have Anti-aging Effects Scientific Studies 15
Gadsie Could Incandescent Lamps Cause Skin Aging Through Infrared? Scientific Studies 2
Atma Drinking 1% Rather Than 2% Milk Accounts For 4.5 Years Of Less Aging In Adults Scientific Studies 9
Mauritio Mainstream Article: "Slowing Down -- Is Aging Caused By Decreased Cellular Metabolism?" Scientific Studies 1
haidut Metabolic Dysfunction Is A Primary Cause Of Aging And Its Symptom Alzheimer Disease (AD) Scientific Studies 3
haidut Increasing Metabolism May Reverse Alzheimer Disease (AD) And General Aging Scientific Studies 3
R What's Your Daily Supplement List To Halt Aging ? (spices/herbs Included) Supplements, Pharmaceutical Drugs 6
M Reverse 30 Years Of Aging While You Sleep Metabolism 3
Inaut #14 - Aging, Mitochondria, Hypoxia, DHEA, Fertility - Danny Roddy With Georgi Dinkov Danny Roddy 12

Similar threads

Top