Activation Of The Endotoxin Receptor (TLR4) May Cause Hearing Loss

Olmec

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@andrewlee224
@Mufasa how did you make it go away? Thank you!
Probably maximum mitigation and reduction of endotoxin production by bacteria. Implying a clean gut with regular/fast transit time and good oral hygeine. TLR4 blockers like cyproheptadine can potentially be of use, but dietary changes should always come first before considering supplements.
Also, consider the influence of dietary fat on endotoxin bloodstream distribution:
...represents the points that I want to make, which I state up front:

(1) Eating Dietary Fat increases the observed gut-derived endotoxin in the bloodstream. The effect usually starts 2-4 hours after eating fat, and lasts for up to 12 hours in healthy subjects [see paper (a)]

(2) The more double bonds in a fat, the LESS endotoxin gets into the serum. A PUFA like DHA will cause less endotoxin to be transferred into the bloodstream, as compared to a Saturated Fat like Coconut Oil. [paper (a)]

(3) In Diabetics, this effect is much more pronounced -- 60% greater levels of circulating endotoxin in serum after eating fat, as compared to "healthy" subjects [paper (b)]

(4) Endotoxin is transported by chylomicrons -- the lipoprotein "Fat Carriers" which transport dietary fat from the GI tract, and deliver them to tissues.

This DOES NOT involve any compromise to intestinal barrier function [paper (c)], but as a result, it is a completely inevitable side effect of consuming fat. ie: if you eat fat, existing endotoxin in the gut can and will be transported into the bloodstream within chylomicrons
 
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