Acetazolamide Plus Thiamine Lower Serotonin And Tryptamine

Discussion in 'Scientific Studies' started by haidut, May 26, 2015.

  1. haidut

    haidut Member

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    Another study showing beneficial effects of the combination acetazolamide + thiamine. The dose used was the same as the one for the schizophrenia study I posted earlier - 2g acetazolamide plus 1.5g thiamine spread into 3 daily doses. The decrease of tryptamine correlated well with improvement in symptoms of tardive dyskinesia. Triptamine is a close relative to serotonin and has very similar metabolic properties, so I think Peat would say the lower its levels the better.

    http://www.biologicalpsychiatryjournal. ... 3/abstract

    "...Urine levels of serotonin and tryptamine were determined by electron-capture gas chromatography on six normal and six chronic schizophrenic males. The patients had fasting urines collected double-blind both during a placebo trial and when administered acetazolamide (2.0 gm in TID divided doses) plus thiamine (500 mgm TID). The normals had fasting specimens collected followed by A + T or placebo, on separate days, and had noon urines collected. The normals’ pre-placebo serotonin (106 + 39 ngm/ml) and tryptamine (53 t 37 ngrn/ml) did not differ significantly from their post placebo noon values, their pre-A + T fasting values, or those of the patients on placebo. Both amines decreased significantly and independently (p < .Ol , t-test) for both groups following A+T administration. The tryptamine decrease remained significant (p <.Ol) after correcting its values for the serotonin changes, to control for diuretic and pH effects of A + T. The patients were given the Abnormal Involuntary Movements Scale under both conditions. Symptom improvement in tardive dyskinesia correlated (r = .97, p < .05) with decreases in urine tryptamine."
     
  2. Blossom

    Blossom Moderator

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    Great information haidut! Thank you so much. It's so sad to me to see severe cases of tardive dyskinesia and in medicine it's treated as permanent and hopeless condition. I knew one person who improved theirs (ancedotal) with high doses of a b-complex supplement. Perhaps it was just the thiamine?
     
  3. OP
    haidut

    haidut Member

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    If the product had biotin in it then it could have helped as well. I posted a study showing biotin doubles levels of CO2 and ATP, but the dosage required was quite high - 200mg-300mg. However, even that high dose is considered safe by the medical profession.
     
  4. Blossom

    Blossom Moderator

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    Great! Would it make sense to use the high dose biotin just until symptoms disappeared and then perhaps try a smaller maintenance dose?
     
  5. OP
    haidut

    haidut Member

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    Well, 300mg biotin daily are used to treat MS. See this thread:
    viewtopic.php?f=75&t=6830

    It did not have side effects and it was considered very safe to take it for extended periods of time. So, depending on her condition she may want to try higher or lower doses and maybe measure lactic acid (as per the other thread) and see what works better. Pretty much every condition on the official medical list has some studies behind it showing increased lactic acid contributes to the pathogenesis. Also, as per the other threads I posted today you may want to suggest to her adding acetazolamide and thiamine to the biotin. These things all seem to act synergistically.
     
  6. Blossom

    Blossom Moderator

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    :D Wow! Thanks, I honestly can't tell you how grateful I am for this information.
     
  7. Parsifal

    Parsifal Member

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    Aren't LSD, DMT and Psilocybin tryptamines?
     
  8. OP
    haidut

    haidut Member

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    LSD is not, it is an ergot derivative.
     
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