Another study showing beneficial effects of the combination acetazolamide + thiamine. The dose used was the same as the one for the schizophrenia study I posted earlier - 2g acetazolamide plus 1.5g thiamine spread into 3 daily doses. The decrease of tryptamine correlated well with improvement in symptoms of tardive dyskinesia. Triptamine is a close relative to serotonin and has very similar metabolic properties, so I think Peat would say the lower its levels the better.
http://www.biologicalpsychiatryjournal. ... 3/abstract
"...Urine levels of serotonin and tryptamine were determined by electron-capture gas chromatography on six normal and six chronic schizophrenic males. The patients had fasting urines collected double-blind both during a placebo trial and when administered acetazolamide (2.0 gm in TID divided doses) plus thiamine (500 mgm TID). The normals had fasting specimens collected followed by A + T or placebo, on separate days, and had noon urines collected. The normals’ pre-placebo serotonin (106 + 39 ngm/ml) and tryptamine (53 t 37 ngrn/ml) did not differ significantly from their post placebo noon values, their pre-A + T fasting values, or those of the patients on placebo. Both amines decreased significantly and independently (p < .Ol , t-test) for both groups following A+T administration. The tryptamine decrease remained significant (p <.Ol) after correcting its values for the serotonin changes, to control for diuretic and pH effects of A + T. The patients were given the Abnormal Involuntary Movements Scale under both conditions. Symptom improvement in tardive dyskinesia correlated (r = .97, p < .05) with decreases in urine tryptamine."
http://www.biologicalpsychiatryjournal. ... 3/abstract
"...Urine levels of serotonin and tryptamine were determined by electron-capture gas chromatography on six normal and six chronic schizophrenic males. The patients had fasting urines collected double-blind both during a placebo trial and when administered acetazolamide (2.0 gm in TID divided doses) plus thiamine (500 mgm TID). The normals had fasting specimens collected followed by A + T or placebo, on separate days, and had noon urines collected. The normals’ pre-placebo serotonin (106 + 39 ngm/ml) and tryptamine (53 t 37 ngrn/ml) did not differ significantly from their post placebo noon values, their pre-A + T fasting values, or those of the patients on placebo. Both amines decreased significantly and independently (p < .Ol , t-test) for both groups following A+T administration. The tryptamine decrease remained significant (p <.Ol) after correcting its values for the serotonin changes, to control for diuretic and pH effects of A + T. The patients were given the Abnormal Involuntary Movements Scale under both conditions. Symptom improvement in tardive dyskinesia correlated (r = .97, p < .05) with decreases in urine tryptamine."