Acetaminophen In Pregnancy Linked To Austism, Possibly Through Serotonin

Koveras

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@haidut has written before about the link between elevated serotonin levels in a mother during pregnancy and autism in babies, and between acetominophen (tylenol/paracetamol) and serotonin.

Stress Activates A Serotonin Gene In Pregnant Women And That Causes Autism
Serotonin Causes Autism; Blocking It May Treat Autism
Maternal Inflammation Causes Brain Damage (autism) By Raising Serotonin
Acetaminophen raises serotonin/adrenaline, aspirin lowers it

It now follows logically that acetominophen use during pregnancy is linked to autism, even though the authors of the study did not make that connection.

"Comparing persistently to nonexposed children, the study has found an increase of 30 per cent in the risk of detriment to some attention functions, and an increase of two clinical symptoms of autism spectrum symptoms in boys.

Researchers in Spain recruited 2644 mother-child pairs in a birth cohort study during pregnancy. 88 per cent were evaluated when the child was one year old, and 79.9 per cent were evaluated when they were five years old. Mothers were asked about their use of paracetamol during pregnancy and the frequency of use was classified as never, sporadic, or persistent. Exact doses could not be noted due to mothers being unable to recall them exactly.

43 per cent of children evaluated at age one and 41 per cent assessed at age five were exposed to any paracetamol at some point during the first 32 weeks of pregnancy. When assessed at age five, exposed children were at higher risk of hyperactivity or impulsivity symptoms. Persistently exposed children in particular showed poorer performance on a computerised test measuring inattention, impulsivity and visual speed processing.

Boys also showed more autism spectrum symptoms when persistently exposed to paracetamol. "

Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms
https://www.sciencedaily.com/releases/2016/07/160701095445.htm
 
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