• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Accutane And Vitamin A: The Cycle - Tips Or Pointers

m_arch

Member
Joined
Jan 5, 2016
Messages
483
Location
Perth, Australia
As a teenager I underwent two rounds of Roaccutane (otherwise known as accutane or Isotretinoin), a synthetic form of vitamin A.
Awhile ago I read online of a study mentioning the long term effects of accutane is increased vitamin A demand of the body - even after treatment, however I haven't been able to find this study again unfortunately.

After reading Nutrition for Women, I tried taking 100,000 UI of vitamin A, every day. I can best describe the effects of supplementing this in one word; regenerative.
It felt like any stress from life barely phased me, and I would just bounce back stronger than previously.
However, over time this effect worse off. I am wondering why. Looking back now, I would probably guess that it lasted around two weeks.
I have since kept up the 100,000 UI of vitamin A, taking this for about 3 or 4 months now.

Do you think my body just got used to the increased vitamin A that is now flowing into my system, and is using it wastefully?
I wonder if I should cycle it on and off so I can feel the regenerative effect again.
As I understand it some supplements can work like this - I'm not sure if vitamin A is one of them.

Or maybe I just need more vitamin A and I should up the dose to 150,000 UI or 200,000 UI.
As a result of accutane I get very dry eyes - and while my skin cleared up of acne, it didn't become blemish free.
While supplementing vit A my skin is now blemish free and my dry eyes have gone - if I stop supplementing in a day or two the dryness comes back.
However my aches and pains have returned, and I don't seem to be as 'regenerative'.
Another possibility is that perhaps something down stream is missing, but I am eating two eggs daily for cholesterol and my metabolism is quite strong.
 

DankMemes

Member
Joined
Aug 12, 2015
Messages
131
Maybe since you've increased your vitamin A intake you might need to increase the other fat soluble vitamins too? I mean if your tissue is saturated with vitamin A then there is less room for K, E and D?

just speculating
 

Orion

Member
Joined
Oct 23, 2015
Messages
834
I have made a few posts, you could read through. I would stick with the high vitamin A, but add in K2 and lots of topical magnesium (make some Magnesium Chloride spray, or epsom salt baths).

Avoid oral vitamin D, get lots of full body sun exposure and avoid PUFA. Aches and pains could be calcification, I believe vitamin A will help remove calcium from soft tissues along with vitamin K directing to skeletal tissues.

I think acne has something to do with broken calcium 'metabolism' in skin cells, could accutane block vitamin A? effectly stopping the pathways, once accutane is stopped the acne usually just starts up again.

Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis. - PubMed - NCBI PUFAs along with low to no vitamin A, too much calcium in skin tissues? (excess oral vitamin D pushes calcium into soft tissues)

Vitamin A has helped my acne immensely, by normalizing keratinization, but has not reduced my sebum production... Do you find that vitamin A is drying your skin out? Maybe just takes a very long time on vitamin A to see full effects. Maybe 6 months to two years, depending on how long you have had acne or if deficient since childhood?
 

m_arch

Member
Thread starter
Joined
Jan 5, 2016
Messages
483
Location
Perth, Australia
I have made a few posts, you could read through. I would stick with the high vitamin A, but add in K2 and lots of topical magnesium (make some Magnesium Chloride spray, or epsom salt baths).

Avoid oral vitamin D, get lots of full body sun exposure and avoid PUFA. Aches and pains could be calcification, I believe vitamin A will help remove calcium from soft tissues along with vitamin K directing to skeletal tissues.

I think acne has something to do with broken calcium 'metabolism' in skin cells, could accutane block vitamin A? effectly stopping the pathways, once accutane is stopped the acne usually just starts up again.

Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis. - PubMed - NCBI PUFAs along with low to no vitamin A, too much calcium in skin tissues? (excess oral vitamin D pushes calcium into soft tissues)

Vitamin A has helped my acne immensely, by normalizing keratinization, but has not reduced my sebum production... Do you find that vitamin A is drying your skin out? Maybe just takes a very long time on vitamin A to see full effects. Maybe 6 months to two years, depending on how long you have had acne or if deficient since childhood?
I have 5mg and Epsom salt baths every second day about. I find they are beneficial too, but not as much as the initial regenerative feeling from initial vitamin a.

Yeah at this point I will keep taking the a, the dry eyes are killer so thats enough.


I just wonder if I can optimise the a, maybe cycle it or up the dose. I'm not sure about the physiology of this vitamin
 

Amazoniac

Member
Joined
Sep 10, 2014
Messages
8,319
Location
Not Uganda
Probably... that's how they claim it causes birth defects... and it could be too potent in regards to certain roles of vitamin A and too weak in regards to others... so all in all it's long term damage. I know someone who claims it made his hair straight, and that's just the side effect he was willing to share... and this is someone who is extra skeptic about real effects of medicines in general...
Retinol and retinyl esters: biochemistry and physiology: Thematic Review Series: Fat-Soluble Vitamins: Vitamin A
"Since there are no known enzymes that can reduce retinoic acid to retinal, excessive or unneeded retinoic acid is not recycled back to retinol/retinyl ester and must be catabolized and eliminated from the body."
 
Joined
Nov 26, 2013
Messages
7,367
Similar threads
Thread starter Title Forum Replies Date
K Attempt to fix my accutane induced hormonal imbalance Hormones 9
T Accutane Hair Loss (IGFBP-3) Hair & Nails 5
outtherebrother Post accutane small bone structure Male Issues 37
F What Supplements Can I Take To Minimize Damage From Accutane? Skin 13
stoic Getting Libido Back After Accutane And Finasteride Male Issues 7
J Should One Avoid High Vit A Foods If They Have Taken Accutane In Their Life? A 12
M ED, Isotretinoin (accutane) And Mild Depression Male Issues 3
J Possibility Of Low Dose Accutane Stunting Penile Growth During Puberty? Male Issues 8
L UNREAL SYMPTOMS; Accutane Side Effects Still The Culprit Of My Suffering? Or Is It Something Else? Ask For Help or Advice 28
A Accutane. Supplements, Pharmaceutical Drugs 0
D GIVING UP: My Accutane Related Hair Loss Update Logs 55
D Accutane And Hair Loss Hair & Nails 11
A Isotretinoin (accutane) Skin 46
aliml Increased activation of vitamin D (1,25D/25D ratio) is likely to be linked to disruption of the bone-kidney-parathyroid endocrine axis. Articles & Scientific Studies 3
sugarbabe *NEW* vitamin D information everyone needs to know! D 36
TypicalJock Does Vitamin E have any contributions to food intolerance? Digestion 1
BearWithMe Vitamin D supps might have shelf life as low as 2 weeks after opening? Ask For Help or Advice 7
Ippodrom47 You CAN get vitamin A toxicity from beta-carotene Scientific Studies 3
L Hypocupremia associated with prior vitamin B12 deficiency Scientific Studies 0
Mauritio Vitamin K, D and A bind to the SARS‐CoV‐2 spike protein Vitamins 28
Ippodrom47 Vitamin A and B12 interactions? Ask For Help or Advice 4
B Vitamin D relation with Cholesterol? Ask For Help or Advice 0
Xavage Peaty way to increase Vitamin K without supplementation? Ask For Help or Advice 8
RenaissanceMan Thoughts on Vitamin A Supplementation alongside T3? Ask For Help or Advice 0
Coffe Vitamin D3 and K2 timing Vitamins 6
E Vitamin D Palpitations (I already take magnesium) Ask For Help or Advice 14
IROM Just ordered Progest-Avail, BHRT Topical Pregnenolone in Vitamin E and BHRT Topical DHEA along with bulk Naringin and Chrysin. Supplements 1
A Why does Vitamin E gives me uterine cramps... Supplements, Pharmaceutical Drugs 4
Pina Proteolytic Enzymes vs Vitamin E - Reversing fibrosis and soft tissue calcification Ask For Help or Advice 38
CHEESEHEAD69 Looking for good quality vitamin d3 supplement cheap? Ask For Help or Advice 22
Coffe Time needed for optimum Vitamin D Vitamins 5
G Vitamin K Absolutely Changed My Face (Wow!) Ask For Help or Advice 13
sugarbabe Trouble going off vitamin C Ask For Help or Advice 77
haidut Vitamin D3 anabolic, calcitriol catabolic for muscle/thymus Scientific Studies 4
haidut Vitamin B1 and/or biotin may treat Huntington Disease (HD) Scientific Studies 35
CiggyTardust Vitamin D3 and Calcification D 14
Mauritio 4000 IU of Vitamin D increases Testosterone by 41% Vitamins 63
youngsinatra Anyone here feeling best on high calcium alone without vitamin D? Ask For Help or Advice 8
F Thyroid glandular vs thyroid meds is like comparing orange juice to vitamin C??? Ask For Help or Advice 2
Elize Vitamin patches Metabolism 5
E Anyone tried Vitamin K2 MK-9? Ask For Help or Advice 4
Braveheart More Evidence That Vitamin D Protects Against Severe COVID-19 Disease and Death D 9
haidut Vitamin A may treat anosmia (loss of smell) due to COVID-19 Scientific Studies 8
M Do policosanols and vitamin b1 have any interactions with other nutrients? how does thiamine affect methyl groups, other b vitamins and histamine? Ask For Help or Advice 0
Broken man Ameliorative effect of curcumin and vitamin B6 against lithocholic acid-induced cholestasis and liver injury in mice Scientific Studies 4
G Any drawbacks to dissolving pregnenolone w/o vitamin E Ask For Help or Advice 0
Hans Vitamin D3 and vit C resolved COVID-19 pneumonia in 3 days Scientific Studies 14
A COVID-19 and Vitamin A Ask For Help or Advice 4
Peatogenic Magnesium activates Vitamin D Testimonials 11
jpgio Vitamin E makes me feel alive Supplements, Pharmaceutical Drugs 11

Similar threads

Top