A Possible Alternative To Cascara

Discussion in 'Cascara Sagrada' started by haidut, Jun 15, 2014.

  1. haidut

    haidut Member

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    Ray mentioned briefly in one of his articles about Koch's work with some of the lesser known anti-cancer substances.

    http://raypeat.com/articles/articles/ca ... buse.shtml

    "...By the time coenzyme Q10, ubiquinone, was officially discovered, Koch had moved to Brazil to continue his work with the biological effects of the quinones, including the anthraquinone compound of brazilwood, which is used as a dye. He also used a naphthoquine, lapachon Although vitamin K was identified as a quinone (naphthoquinone) not long after coQ10 was found to be a ubiquitous component of the mitochondrial respiratory system, it wasn’t immediately recognized as another participant in that system, interacting with coQ10."

    http://en.wikipedia.org/wiki/Lapachol

    The compound is a quinone and closely related to vitamin K, which would explain its many beneficial effects. The substance is usually isolated from the bark of the Lapacho tree:
    http://en.wikipedia.org/wiki/Handroanthus_impetiginosus

    What I find interesting is that just like Cascara, the extract from the Lapacho tree has many gut protective properties, and can probably be used in lieu of Cascara, and at a much lower cost. I personally don't know of another natural remedy that has strong anti-viral properties in the gut, anti Candida activity, anti H. Pylori (ulcer) activity, and finally anti-cancer activity.

    http://en.wikipedia.org/wiki/Handroanthus_impetiginosus

    "...In ethnomedicine, Lapacho plays an important role for several South American indigenous peoples. In the past decades it has been used by herbalists as a general tonic, immunostimulant,[8] and adaptogen. It is used in herbal medicine for intestinal candidiasis.[9]
    However, the main active compound lapachol has since turned out to be toxic enough to kill fetuses in pregnant rats and reduce the weight of the seminal vesicle in male rats in doses of 100 mg/kg of body weight.[10] Still, lapachol has strong antibiotic and disinfectant properties, and may be better suited for topical applications. Lapachol induces genetic damage, specifically clastogenic effects, in rats.[11] Beta-lapachone has a direct cytotoxic effect and the loss of telomerase activity in leukemia cells in vitro.[12]
    The ethnomedical use of Lapacho and other Handroanthus teas is usually short-term, to get rid of acute ailments, and not as a general tonic. Usefulness as a short-term antimicrobial and disinfecting expectorant, e.g. against PCP in AIDS patients, is yet to be scientifically studied. Handroanthus impetiginosus inner bark seems to have anti-Helicobacter pylori activity.[13] and has some effects on other human intestinal bacteria.[14]"

    In USA the Lapacho tree is known as Pau D'Arco and extract in pills or powder can be bought cheaply in most health stores. If anybody knows more about it or has talked to peat about it, please share whatever info you have.
     
  2. 4peatssake

    4peatssake Member

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    Very interesting. Thanks haidut.

    I've heard of this but for the life of me can't remember the context nor can locate any information in my files. :?

    I came across this advice online when purchasing.
    Paudarco.org

    Going to look into this more. Thanks again for the info.
     
  3. 4peatssake

    4peatssake Member

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    I just bought some bark from iherb and lucked into some reward deal and only had to pay for shipping.

    It's a good deal to start with at only $9.80 for Frontier Natural Products, Cut & Sifted, Pau d'Arco Bark, 16 oz (453 g)

    It was a product featured on the site I linked earlier and comes from the inner bark.

    Link to Product on iHerb
     
  4. Kray

    Kray Member

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    Haidut,

    Have you done any further research into pau d'arco's use, especially taken internally? Seems somewhat questionable from the references above and others I've read online, especially long-term. Thanks-
     
  5. OP
    haidut

    haidut Member

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    I took it about a year ago but it was on alternate days with Cascara, so my symptoms got resolved but I can't tell if it was the Cascara or lapachon that helped more. I started this thread since I know of some people who cannot tolerate Cascara at all but can tolerate lapachon and it resolved much of their stomach issues. I have not done much research beyond some reading on Pubmed showing lapachon has a strong anti-obesity effect, which is to be expected given that it is a quinone and it stimulates metabolism.
    Sorry I don't have more info. Ray may have looked more into it given that Koch was experimenting with it for cancer.
     
  6. aquaman

    aquaman Member

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    INteresting!

    I'm sure in one of the Radio interviews Peat with the Herb Doctors RP talks about the benefits of Lapacho, and then asks the Docs if it's called Pau D'Arco in herbal medicine (to which they agree)... anyone remember the episode?
     
  7. Kray

    Kray Member

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    Haidut, Aquaman, thanks for the posts. I had been taking both capsules and tea. For now I'm taking a break. Seems like a word search, 'ray peat and lapacho' might bring up a link?
     
  8. 4peatssake

    4peatssake Member

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    Haidut, I've come across additional comment from Peat regarding pau d'arco, cascara and Vit K. I've been taking the tea for 2 days (currently on day 3) and I'm noticing some good effects. I think I'm going to start taking Vitamin K again as the combination seems really good particularly for the liver.

    This is from the transcript of Ray Peat's KMUD Endotoxin interview, Nov. 19, 2010
     
  9. Blossom

    Blossom Moderator

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    Great quote!
     
  10. Dayman

    Dayman Member

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    Any recommended brands?
     
  11. Blossom

    Blossom Moderator

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  12. lindsay

    lindsay Member

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    I'm pretty sure that RP mentions this stuff on his last interview with the Herb doctors - he says Tabebuia works similarly to Methylene Blue (or at least it's the closest natural substance). But Methylene Blue is super cheap - weren't you giving it a run Haidut? How did MB work for you?

    I'd be interested to try Tabebuia - for all the good RP says of cascara, I don't find it's helped my digestion a whole lot. In fact, the Senna tea I used to drink gave me less stomach irritation. Then again, it could be the gelatin capsule that gives me issues with cascara. Maybe I should try making a tea with it.....
     
  13. OP
    haidut

    haidut Member

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    MB is great, I was taking it in doses of 15mg a day as per the human study. However, I found that it has the same effect as the powerful incandescent lights that I am using at night, which is expected since both therapies result in removing NO from cytochrome c oxidase. So, between taking a drug and basking in the light I chose the latter:):
    That being said, I keep my MB around since I also found it kills flu symptoms within a day of taking it. So, for now MB would be my go to flu shot combined with some theanine and zinc, which have also been shown to stop the flu.
     
  14. bzmazu

    bzmazu Member

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    Just added this to my herbal anti cancer arsenal, plus for the gut health...1 tsp every other day in oj...immediately/finally my bowel movements are perfect...cascara every other day was working but not as well as wanted...now I alternate them....feels good, I like it...and there seems to be a list of benefits.
     
  15. OP
    haidut

    haidut Member

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    The lapachol and beta-lapachone are quinones and very similar to vitamin K in structure and activity. You probably would not be surprised to learn that while big pharma is publicly bashing "alternative" cancer treatments like lapachone, privately it is running some clinical trials with beta-lapachone for pancreatic cancer. How much do you want to bet that by the time the trial is over, lapacho bark extract will be banned for sale as a supplement and will become a "drug"?
    ARQ-761 Treatment With Gemcitabine/Nab-Paclitaxel Chemotherapy In Pancreatic Cancer - Full Text View - ClinicalTrials.gov
    ARQ 501 in Combination With Gemcitabine in Subjects With Pancreatic Cancer - Full Text View - ClinicalTrials.gov
     
  16. bzmazu

    bzmazu Member

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    Pig Pharma is causing me stress....truely.
     
  17. Blossom

    Blossom Moderator

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    Good one! :lol:
     
  18. Parsifal

    Parsifal Member

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    Haidut, do you know what where all Koch reagents? If I remember, he created synthetic quinones?
     
  19. Birdie

    Birdie Member

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    I just bought the now brand of Pau d'Arco capsules locally. Cheaper than amazon.
    Used the tea for years but hated the taste and switched to cascara via Peat.

    Those paragraphs from the transcripts of the Herb Doctors' interview are intriguing. Thanks @peatssake.
    Thanks to @bzmazu for bringing the thread back. To @haidut for starting it two years ago.

    This may be a key player for me. High hopes.
     
  20. Kray

    Kray Member

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    I'm interested to know more about your "regularity" regimen. Can you clarify what you're taking 1 tsp/day in combo with cascara, per above? Pau d'arco, or some other? Tea form, liquid tincture? Link? What dose of cascara?

    Are you still doing this, and is it ok to take both long-term?

    Thanks
     
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